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2nsu

Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM reconstruction of canine parvovirus and feline transferrin receptor complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transferrin receptor protein 1

Homo sapiens

UniProt P02786

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6y76 6y76 8p0z

3 assemblies

Homodimer
11qc 1cx8 1cx8 1cx8 1cx8 2nsu

6 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
11rn 1de4 1de4 1suv 3kas 3s9l 3s9l 3s9m 3s9m 3s9n 3s9n 6d03

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TFR1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–639； UniProt 122–760 Author chain B； PDBConstruct 1–639； UniProt 122–760

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2nsu
Deposition date deposition_date2006-11-06
Structure title titleCrystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM reconstruction of canine parvovirus and feline transferrin receptor complex
Keywords keywordstransferrin receptor, virus-receptor complex, METAL TRANSPORT; METAL TRANSPORT
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2nsu__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2nsu__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2nsu__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.94 Å
Rg (electron density)34.14 Å
Total Rg34.91 Å
Atom count10112
Residues1278
Excluded volume180350 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2nsu__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd2nsua1
Class classa — All alpha proteins
Fold Fold folda.48 — N-cbl like
Superfamily Superfamily superfamilya.48.2 — Transferrin receptor-like dimerisation domain
Family Family familya.48.2.1 — Transferrin receptor-like dimerisation domain
Domain ID domain_idd2nsua2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.8 — The 'swivelling' beta/beta/alpha domain
Superfamily Superfamily superfamilyc.8.4 — PA domain
Family Family familyc.8.4.1 — PA domain
Domain ID domain_idd2nsua3
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.56 — Phosphorylase/hydrolase-like
Superfamily Superfamily superfamilyc.56.5 — Zn-dependent exopeptidases
Family Family familyc.56.5.5 — FolH catalytic domain-like
Domain ID domain_idd2nsub1
Class classa — All alpha proteins
Fold Fold folda.48 — N-cbl like
Superfamily Superfamily superfamilya.48.2 — Transferrin receptor-like dimerisation domain
Family Family familya.48.2.1 — Transferrin receptor-like dimerisation domain
Domain ID domain_idd2nsub2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.8 — The 'swivelling' beta/beta/alpha domain
Superfamily Superfamily superfamilyc.8.4 — PA domain
Family Family familyc.8.4.1 — PA domain
Domain ID domain_idd2nsub3
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.56 — Phosphorylase/hydrolase-like
Superfamily Superfamily superfamilyc.56.5 — Zn-dependent exopeptidases
Family Family familyc.56.5.5 — FolH catalytic domain-like
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7. Citations (1)