2onm

Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with NAD+

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Aldehyde dehydrogenase, mitochondrial precursor

Homo sapiens

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 4	SODIUM ION × 6 ADENOSINE-5'-DIPHOSPHATE × 2 1,2-ETHANEDIOL × 8 GUANIDINE × 2 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 water × 4	与蛋白数一致
2	蛋白同源多聚体	同源多聚体	蛋白 4	SODIUM ION × 6 ADENOSINE-5'-DIPHOSPHATE × 1 1,2-ETHANEDIOL × 12 GUANIDINE × 5 NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 3 water × 4	与蛋白数一致
3	蛋白同源多聚体	同源多聚体	蛋白 4	SODIUM ION × 5 ADENOSINE-5'-DIPHOSPHATE × 4 1,2-ETHANEDIOL × 5 GUANIDINE × 2 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	ALDH2_HUMAN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–500； UniProt 18–517 作者链 B； PDB构建体 1–500； UniProt 18–517 作者链 C； PDB构建体 1–500； UniProt 18–517 作者链 D； PDB构建体 1–500； UniProt 18–517 作者链 E； PDB构建体 1–500； UniProt 18–517 作者链 F； PDB构建体 1–500； UniProt 18–517 作者链 G； PDB构建体 1–500； UniProt 18–517 作者链 H； PDB构建体 1–500； UniProt 18–517 作者链 I； PDB构建体 1–500； UniProt 18–517 作者链 J； PDB构建体 1–500； UniProt 18–517 作者链 K； PDB构建体 1–500； UniProt 18–517 作者链 L； PDB构建体 1–500； UniProt 18–517

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	2onm
沉积日期 deposition_date	2007-01-24
结构标题 title	Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with NAD+
关键词 keywords	oxidoreductase, ALDH, NAD, Rossmann Fold; OXIDOREDUCTASE
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2onm__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2onm__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

2onm__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	36.71 Å
Rg（电子密度）	35.95 Å
总 Rg	36.53 Å
原子数	15380
残基数	1976
排除体积	273510 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`2onm__assembly_1__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`2onm__assembly_2__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
3	1	`2onm__assembly_3__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

描述 description	Aldehyde dehydrogenase, mitochondrial precursor
分子量 formula_weight	54499.7 kDa
EC 编号 ec_number	1.2.1.3
突变 mutation	E487K
来源方法 src_method	man
拷贝数 entity_count	12

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H,I,J,K,L
原子数 atom_count	48124

SAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTKVKTVTVKVPQKNS

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	human
NCBI 分类编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Escherichia coli BL21(DE3)

实体 2 Entity 2 non-polymer

描述 description	SODIUM ION
分子量 formula_weight	23.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	17

实体 3 Entity 3 non-polymer

描述 description	ADENOSINE-5'-DIPHOSPHATE
分子量 formula_weight	427.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	7

实体 4 Entity 4 non-polymer

描述 description	1,2-ETHANEDIOL
分子量 formula_weight	62.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	25

实体 5 Entity 5 non-polymer

描述 description	GUANIDINE
分子量 formula_weight	59.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	9

实体 6 Entity 6 non-polymer

描述 description	NICOTINAMIDE-ADENINE-DINUCLEOTIDE
分子量 formula_weight	663.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	5

实体 7 Entity 7 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	1932

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6. 折叠分类 (SCOP + CATH) 36 domains

SCOP 2.08 (12 domains)

结构域编号 domain_id	d2onma_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmb_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmc_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmd_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onme_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmf_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmg_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmh_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmi_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmj_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onmk_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

结构域编号 domain_id	d2onml_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.82 — ALDH-like
超家族 Superfamily superfamily	c.82.1 — ALDH-like
家族 Family family	c.82.1.1 — ALDH-like

CATH v4.4 (24 domains)

结构域编号 domain_id	2onmA01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmA02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmB01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmB02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmC01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmC02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmD01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmD02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmE01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmE02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmF01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmF02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmG01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmG02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmH01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmH02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmI01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmI02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmJ01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmJ02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmK01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmK02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

结构域编号 domain_id	2onmL01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	605 — Aldehyde Dehydrogenase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 1

结构域编号 domain_id	2onmL02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	40 — 3-Layer(aba) Sandwich
拓扑 Topology topology	309 — Aldehyde Dehydrogenase; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Aldehyde Dehydrogenase; Chain A, domain 2

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晶胞边长 a length_a	96.201 Å
晶胞边长 b length_b	104.854 Å
晶胞边长 c length_c	162.359 Å
晶胞夹角 α angle_alpha	78.99 °
晶胞夹角 β angle_beta	82.14 °
晶胞夹角 γ angle_gamma	88.55 °
晶胞分子数 Z z_pdb	12

空间群 space_group	P 1
空间群编号 int_tables_number	1
晶系 crystal_system	—

分辨率 resolution	2.500 Å
最低分辨率 resolution_low	44.010 Å
R 因子 r_factor	0.2330
R_work r_work	0.2300
R_free r_free	0.2710

Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with NAD+

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Aldehyde dehydrogenase, mitochondrial precursor

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2onm__assembly_1__model_1

2onm__assembly_1__model_1 | I(q)

2onm__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 water

6. 折叠分类 (SCOP + CATH) 36 domains

SCOP 2.08 (12 domains)

CATH v4.4 (24 domains)

7. 引用文献 (1)

Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with NAD+

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Aldehyde dehydrogenase, mitochondrial precursor

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2onm__assembly_1__model_1

2onm__assembly_1__model_1 | I(q)

2onm__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 non-polymer

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 water

6. 折叠分类 (SCOP + CATH) 36 domains

SCOP 2.08 (12 domains)

CATH v4.4 (24 domains)

7. 引用文献 (1)