2vkz

Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

FATTY ACID SYNTHASE SUBUNIT ALPHA

物种未注明

UniProt P19097

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 6 FATTY ACID SYNTHASE SUBUNIT BETA × 3 (P07149) (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE × 3 FLAVIN MONONUCLEOTIDE × 3 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FAS2_YEAST
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–1887; UniProt 1–1887 作者链 B; PDB构建体 1–1887; UniProt 1–1887 作者链 C; PDB构建体 1–1887; UniProt 1–1887

FATTY ACID SYNTHASE SUBUNIT BETA

物种未注明

UniProt P07149

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 6 FATTY ACID SYNTHASE SUBUNIT ALPHA × 3 (P19097) (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE × 3 FLAVIN MONONUCLEOTIDE × 3 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FAS1_YEAST
Isoform —
PDB实体 2
链与序列区间 作者链 G; PDB构建体 1–2051; UniProt 1–2051 作者链 H; PDB构建体 1–2051; UniProt 1–2051 作者链 I; PDB构建体 1–2051; UniProt 1–2051

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2vkz
沉积日期 deposition_date2008-01-07
结构标题 titleStructure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex
关键词 keywords;TRANSFERASE, PHOSPHORYLATION, PHOSPHOPANTETHEINE, FATTY ACID SYNTHASE, MULTIFUNCTIONAL ENZYME, OXIDOREDUCTASE, LIPID SYNTHESIS, FAS, NAD, NADP, LYASE, CERULENIN, HYDROLASE, FATTY ACID BIOSYNTHESIS ;; TRANSFERASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2vkz__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2vkz__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2vkz__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)89.29 Å
Rg(电子密度)88.23 Å
总 Rg88.34 Å
原子数85959
残基数10941
排除体积1536600 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2vkz__assembly_1__model_1 hexameric (6) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (4)

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6. 折叠分类 (SCOP + CATH) 39 domains

CATH v4.4 (39 domains)

结构域编号 domain_id2vkzA01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology25 — UDP-galactose 4-epimerase; domain 1
同源超家族 H-superfamily homologous superfamily70 —
结构域编号 domain_id2vkzA02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Thiolase/Chalcone synthase
结构域编号 domain_id2vkzB01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology25 — UDP-galactose 4-epimerase; domain 1
同源超家族 H-superfamily homologous superfamily70 —
结构域编号 domain_id2vkzB02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Thiolase/Chalcone synthase
结构域编号 domain_id2vkzC01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology25 — UDP-galactose 4-epimerase; domain 1
同源超家族 H-superfamily homologous superfamily70 —
结构域编号 domain_id2vkzC02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology47 — Peroxisomal Thiolase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Thiolase/Chalcone synthase
结构域编号 domain_id2vkzG01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1050 — Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
同源超家族 H-superfamily homologous superfamily120 —
结构域编号 domain_id2vkzG02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
同源超家族 H-superfamily homologous superfamily10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2
结构域编号 domain_id2vkzG03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily3320 —
结构域编号 domain_id2vkzG04
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily70 — Aldolase class I
结构域编号 domain_id2vkzG06
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology930 — Transcription Elongation Factor S-II; Chain A
同源超家族 H-superfamily homologous superfamily70 —
结构域编号 domain_id2vkzG07
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1120 — Arylsulfatase, C-terminal domain
同源超家族 H-superfamily homologous superfamily100 —
结构域编号 domain_id2vkzG08
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology129 — Thiol Ester Dehydrase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Hotdog Thioesterase
结构域编号 domain_id2vkzG09
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology128 — Lipocalin
同源超家族 H-superfamily homologous superfamily700 —
结构域编号 domain_id2vkzG11
类 Class class6 — Special
架构 Architecture architecture10 — Helix non-globular
拓扑 Topology topology60 — Hydrophobic Seed Protein
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id2vkzG12
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily3330 —
结构域编号 domain_id2vkzG13
类 Class class6 — Special
架构 Architecture architecture10 — Helix non-globular
拓扑 Topology topology140 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily1400 —
结构域编号 domain_id2vkzH01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1050 — Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
同源超家族 H-superfamily homologous superfamily120 —
结构域编号 domain_id2vkzH02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
同源超家族 H-superfamily homologous superfamily10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2
结构域编号 domain_id2vkzH03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily3320 —
结构域编号 domain_id2vkzH04
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily70 — Aldolase class I
结构域编号 domain_id2vkzH06
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology930 — Transcription Elongation Factor S-II; Chain A
同源超家族 H-superfamily homologous superfamily70 —
结构域编号 domain_id2vkzH07
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1120 — Arylsulfatase, C-terminal domain
同源超家族 H-superfamily homologous superfamily100 —
结构域编号 domain_id2vkzH08
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology129 — Thiol Ester Dehydrase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Hotdog Thioesterase
结构域编号 domain_id2vkzH09
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology128 — Lipocalin
同源超家族 H-superfamily homologous superfamily700 —
结构域编号 domain_id2vkzH11
类 Class class6 — Special
架构 Architecture architecture10 — Helix non-globular
拓扑 Topology topology60 — Hydrophobic Seed Protein
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id2vkzH12
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily3330 —
结构域编号 domain_id2vkzH13
类 Class class6 — Special
架构 Architecture architecture10 — Helix non-globular
拓扑 Topology topology140 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily1400 —
结构域编号 domain_id2vkzI01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1050 — Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
同源超家族 H-superfamily homologous superfamily120 —
结构域编号 domain_id2vkzI02
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology366 — Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
同源超家族 H-superfamily homologous superfamily10 — Malonyl-Coenzyme A Acyl Carrier Protein, domain 2
结构域编号 domain_id2vkzI03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily3320 —
结构域编号 domain_id2vkzI04
类 Class class3 — Alpha Beta
架构 Architecture architecture20 — Alpha-Beta Barrel
拓扑 Topology topology20 — TIM Barrel
同源超家族 H-superfamily homologous superfamily70 — Aldolase class I
结构域编号 domain_id2vkzI06
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology930 — Transcription Elongation Factor S-II; Chain A
同源超家族 H-superfamily homologous superfamily70 —
结构域编号 domain_id2vkzI07
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1120 — Arylsulfatase, C-terminal domain
同源超家族 H-superfamily homologous superfamily100 —
结构域编号 domain_id2vkzI08
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology129 — Thiol Ester Dehydrase; Chain A
同源超家族 H-superfamily homologous superfamily10 — Hotdog Thioesterase
结构域编号 domain_id2vkzI09
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology128 — Lipocalin
同源超家族 H-superfamily homologous superfamily700 —
结构域编号 domain_id2vkzI11
类 Class class6 — Special
架构 Architecture architecture10 — Helix non-globular
拓扑 Topology topology60 — Hydrophobic Seed Protein
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id2vkzI12
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology70 — Alpha-Beta Plaits
同源超家族 H-superfamily homologous superfamily3330 —
结构域编号 domain_id2vkzI13
类 Class class6 — Special
架构 Architecture architecture10 — Helix non-globular
拓扑 Topology topology140 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily1400 —
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7. 引用文献 (1)