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2w2h

Structural basis of transcription activation by the Cyclin T1-Tat-TAR RNA complex from EIAV

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

CYCLIN-T1

EQUUS CABALLUS

UniProt Q9XT26

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 2 RNA 1 PROTEIN TAT × 1 （P20920） ;5'-R(*GP*CP*UP*CP*AP*GP*AP*UP*CP*UP *GP*CP*GP*GP*UP*CP*UP*GP*AP*GP*C)-3' ; × 1 MANGANESE (II) ION × 2 water × 1 Consistent with all polymers
2 Protein–RNA Heteromer Protein 2 RNA 1 PROTEIN TAT × 1 （P20920） ;5'-R(*GP*CP*UP*CP*AP*GP*AP*UP*CP*UP *GP*CP*GP*GP*UP*CP*UP*GP*AP*GP*C)-3' ; × 1 water × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2w2h 2w2h

2 assemblies

View Construct and Data Evidence
UniProt name CCNT1_HORSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–264； UniProt 5–267 Author chain B； PDBConstruct 2–264； UniProt 5–267

PROTEIN TAT

EQUINE INFECTIOUS ANEMIA VIRUS

UniProt P20920

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 2 RNA 1 CYCLIN-T1 × 1 （Q9XT26） ;5'-R(*GP*CP*UP*CP*AP*GP*AP*UP*CP*UP *GP*CP*GP*GP*UP*CP*UP*GP*AP*GP*C)-3' ; × 1 MANGANESE (II) ION × 2 water × 1 Consistent with all polymers
2 Protein–RNA Heteromer Protein 2 RNA 1 CYCLIN-T1 × 1 （Q9XT26） ;5'-R(*GP*CP*UP*CP*AP*GP*AP*UP*CP*UP *GP*CP*GP*GP*UP*CP*UP*GP*AP*GP*C)-3' ; × 1 water × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2w2h 2w2h

2 assemblies

View Construct and Data Evidence
UniProt name TAT_EIAVY
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–29； UniProt 47–75 Author chain D； PDBConstruct 1–29； UniProt 47–75

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2w2h
Deposition date deposition_date2008-10-30
Structure title titleStructural basis of transcription activation by the Cyclin T1-Tat-TAR RNA complex from EIAV
Keywords keywords;RNA-BINDING PROTEIN, TAR, TAT, CYCLIN, NUCLEUS, ACTIVATOR, CYCLIN T1, HOST-VIRUS INTERACTION, TRANSCRIPTION REGULATION, CELL CYCLE, RNA-BINDING, ACETYLATION, COILED COIL, TRANSCRIPTION, CELL DIVISION, CRYSTALLIZATION, RNA BINDING PROTEIN ;; RNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2w2h__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2w2h__assembly_2__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2w2h__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.47 Å
Rg (electron density)22.20 Å
Total Rg23.10 Å
Atom count2782
Residues311
Excluded volume47866 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2w2h__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 2w2h__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 4 domains

CATH v4.4 (4 domains)

Domain ID domain_id2w2hA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
Domain ID domain_id2w2hA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
Domain ID domain_id2w2hB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
Domain ID domain_id2w2hB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily10 — Cyclin-like
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7. Citations (1)