2wqy

Remodelling of carboxin binding to the Q-site of avian respiratory complex II

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT

物种未注明

UniProt Q9YHT1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE IP SUBUNIT × 1 (Q9YHT2) SUCCINATE DEHYDROGENASE CYTOCHROME B, LARGE SUBUNIT × 1 SUCCINATE DEHYDROGENASE CYTOCHROME B, SMALL SUBUNIT × 1 (Q5ZIS0) UNKNOWN LIGAND × 55 POTASSIUM ION × 2 AZIDE ION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 OXALOACETATE ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 GLYCEROL × 2 hexyl beta-D-galactopyranoside × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE IP SUBUNIT × 1 (Q9YHT2) SUCCINATE DEHYDROGENASE CYTOCHROME B, LARGE SUBUNIT × 1 SUCCINATE DEHYDROGENASE CYTOCHROME B, SMALL SUBUNIT × 1 (Q5ZIS0) UNKNOWN LIGAND × 40 POTASSIUM ION × 2 FLAVIN-ADENINE DINUCLEOTIDE × 1 OXALOACETATE ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 GLYCEROL × 2 hexyl beta-D-galactopyranoside × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSA_CHICK
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–621; UniProt 45–665 作者链 N; PDB构建体 1–621; UniProt 45–665

SUCCINATE DEHYDROGENASE IP SUBUNIT

物种未注明

UniProt Q9YHT2

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (Q9YHT1) SUCCINATE DEHYDROGENASE CYTOCHROME B, LARGE SUBUNIT × 1 SUCCINATE DEHYDROGENASE CYTOCHROME B, SMALL SUBUNIT × 1 (Q5ZIS0) UNKNOWN LIGAND × 55 POTASSIUM ION × 2 AZIDE ION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 OXALOACETATE ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 GLYCEROL × 2 hexyl beta-D-galactopyranoside × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (Q9YHT1) SUCCINATE DEHYDROGENASE CYTOCHROME B, LARGE SUBUNIT × 1 SUCCINATE DEHYDROGENASE CYTOCHROME B, SMALL SUBUNIT × 1 (Q5ZIS0) UNKNOWN LIGAND × 40 POTASSIUM ION × 2 FLAVIN-ADENINE DINUCLEOTIDE × 1 OXALOACETATE ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 GLYCEROL × 2 hexyl beta-D-galactopyranoside × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSB_CHICK
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–252; UniProt 39–290 作者链 O; PDB构建体 1–252; UniProt 39–290

SUCCINATE DEHYDROGENASE CYTOCHROME B, SMALL SUBUNIT

物种未注明

UniProt Q5ZIS0

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (Q9YHT1) SUCCINATE DEHYDROGENASE IP SUBUNIT × 1 (Q9YHT2) SUCCINATE DEHYDROGENASE CYTOCHROME B, LARGE SUBUNIT × 1 UNKNOWN LIGAND × 55 POTASSIUM ION × 2 AZIDE ION × 1 FLAVIN-ADENINE DINUCLEOTIDE × 1 OXALOACETATE ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 GLYCEROL × 2 hexyl beta-D-galactopyranoside × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 water × 4 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (Q9YHT1) SUCCINATE DEHYDROGENASE IP SUBUNIT × 1 (Q9YHT2) SUCCINATE DEHYDROGENASE CYTOCHROME B, LARGE SUBUNIT × 1 UNKNOWN LIGAND × 40 POTASSIUM ION × 2 FLAVIN-ADENINE DINUCLEOTIDE × 1 OXALOACETATE ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 GLYCEROL × 2 hexyl beta-D-galactopyranoside × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSD_CHICK
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–103; UniProt 55–157 作者链 Q; PDB构建体 1–103; UniProt 55–157

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2wqy
沉积日期 deposition_date2009-08-27
结构标题 titleRemodelling of carboxin binding to the Q-site of avian respiratory complex II
关键词 keywords;OXALOACETATE NITROPROPIONATE UBIQUINONE, RESPIRATORY CHAIN, COMPLEX II, CYTOCROME B, REDOX ENZYME, HEME PROTEIN, FLAVOPROTEIN, OXIDOREDUCTASE, METAL-BINDING, MITOCHONDRION INNER MEMBRANE, IRON SULFUR PROTEIN, TRICARBOXYLIC ACID CYCLE ;; OXIDOREDUCTASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2wqy__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2wqy__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2wqy__assembly_2__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)32.60 Å
Rg(电子密度)33.32 Å
总 Rg33.39 Å
原子数8731
残基数1092
排除体积155780 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2wqy__assembly_1__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2wqy__assembly_2__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (18)

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6. 折叠分类 (SCOP + CATH) 26 domains

SCOP 2.08 (8 domains)

结构域编号 domain_idd2wqyb1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamilyd.15.4 — 2Fe-2S ferredoxin-like
家族 Family familyd.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins
结构域编号 domain_idd2wqyb2
类 Class classa — All alpha proteins
折叠类型 Fold folda.1 — Globin-like
超家族 Superfamily superfamilya.1.2 — alpha-helical ferredoxin
家族 Family familya.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain
结构域编号 domain_idd2wqyc_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)
结构域编号 domain_idd2wqyd_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)
结构域编号 domain_idd2wqyo1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamilyd.15.4 — 2Fe-2S ferredoxin-like
家族 Family familyd.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins
结构域编号 domain_idd2wqyo2
类 Class classa — All alpha proteins
折叠类型 Fold folda.1 — Globin-like
超家族 Superfamily superfamilya.1.2 — alpha-helical ferredoxin
家族 Family familya.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain
结构域编号 domain_idd2wqyp_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)
结构域编号 domain_idd2wqyq_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family familyf.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

CATH v4.4 (18 domains)

结构域编号 domain_id2wqyA01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id2wqyA02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id2wqyA03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id2wqyA04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id2wqyB01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id2wqyB02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id2wqyC01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily540 — Single helix bin
结构域编号 domain_id2wqyC02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2wqyD00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2wqyN01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id2wqyN02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id2wqyN03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id2wqyN04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id2wqyO01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id2wqyO02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id2wqyP01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily540 — Single helix bin
结构域编号 domain_id2wqyP02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2wqyQ00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
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7. 引用文献 (2)