2ws3

Crystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhD Tyr83Phe mutant

Method: X-RAY DIFFRACTION
▼

1. 蛋白身份与相关结构 Protein Identity & Related Structures

SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT

ESCHERICHIA COLI

UniProt P0AC41

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSA_ECOLI
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–588; UniProt 1–588 作者链 E; PDB构建体 1–588; UniProt 1–588 作者链 I; PDB构建体 1–588; UniProt 1–588

SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT

ESCHERICHIA COLI

UniProt P07014

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSB_ECOLI
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–238; UniProt 1–238 作者链 F; PDB构建体 1–238; UniProt 1–238 作者链 J; PDB构建体 1–238; UniProt 1–238

SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT

ESCHERICHIA COLI

UniProt P69054

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT × 1 (P0AC44) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSC_ECOLI
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–129; UniProt 1–129 作者链 G; PDB构建体 1–129; UniProt 1–129 作者链 K; PDB构建体 1–129; UniProt 1–129

SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT

ESCHERICHIA COLI

UniProt P0AC44

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 4 SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 (P0AC41) SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 (P07014) SUCCINATE DEHYDROGENASE CYTOCHROME B-556 SUBUNIT × 1 (P69054) FLAVIN-ADENINE DINUCLEOTIDE × 1 SODIUM ION × 1 MALATE LIKE INTERMEDIATE × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DHSD_ECOLI
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–115; UniProt 1–115 作者链 H; PDB构建体 1–115; UniProt 1–115 作者链 L; PDB构建体 1–115; UniProt 1–115

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

▼

2. 结构基本信息 2. Structure Basics

条目编号 entry_id2ws3
沉积日期 deposition_date2009-09-03
结构标题 titleCrystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhD Tyr83Phe mutant
关键词 keywordsELECTRON TRANSPORT, OXIDOREDUCTASE; OXIDOREDUCTASE
实验方法 methodX-RAY DIFFRACTION
▼

3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2ws3__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2ws3__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2ws3__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)32.49 Å
Rg(电子密度)33.25 Å
总 Rg33.31 Å
原子数8300
残基数1052
排除体积148190 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2ws3__assembly_1__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 2ws3__assembly_2__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 2ws3__assembly_3__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
▶

4. 晶体学与实验 4. Crystallography & Experiment

▶

5. 实体与聚合物信息 Entities & Polymers (12)

▼

6. 折叠分类 (SCOP + CATH) 24 domains

CATH v4.4 (24 domains)

结构域编号 domain_id2ws3A01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id2ws3A02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id2ws3A03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id2ws3A04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id2ws3B01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id2ws3B02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id2ws3C00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2ws3D00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2ws3E01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id2ws3E02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id2ws3E03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id2ws3E04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id2ws3F01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id2ws3F02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id2ws3G00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2ws3H00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2ws3I01
类 Class class3 — Alpha Beta
架构 Architecture architecture50 — 3-Layer(bba) Sandwich
拓扑 Topology topology50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily60 — FAD/NAD(P)-binding domain
结构域编号 domain_id2ws3I02
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
结构域编号 domain_id2ws3I03
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
结构域编号 domain_id2ws3I04
类 Class class4 — Few Secondary Structures
架构 Architecture architecture10 — Irregular
拓扑 Topology topology80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily40 — succinate dehydrogenase protein domain
结构域编号 domain_id2ws3J01
类 Class class3 — Alpha Beta
架构 Architecture architecture10 — Roll
拓扑 Topology topology20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily30 — Beta-grasp domain
结构域编号 domain_id2ws3J02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily10 — Alpha-helical ferredoxin
结构域编号 domain_id2ws3K00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
结构域编号 domain_id2ws3L00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit
▶

7. 引用文献 (1)