2wu5

Crystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhD His71Met mutant

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT

ESCHERICHIA COLI

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
2	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
3	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	DHSA_ECOLI
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–588； UniProt 1–588 作者链 E； PDB构建体 1–588； UniProt 1–588 作者链 I； PDB构建体 1–588； UniProt 1–588

SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT

ESCHERICHIA COLI

UniProt P07014

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
2	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
3	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	DHSB_ECOLI
Isoform	—
PDB实体	2
链与序列区间	作者链 B； PDB构建体 1–238； UniProt 1–238 作者链 F； PDB构建体 1–238； UniProt 1–238 作者链 J； PDB构建体 1–238； UniProt 1–238

SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT

ESCHERICHIA COLI

UniProt P69054

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
2	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
3	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT × 1 （P0AC44） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	DHSC_ECOLI
Isoform	—
PDB实体	3
链与序列区间	作者链 C； PDB构建体 1–129； UniProt 1–129 作者链 G； PDB构建体 1–129； UniProt 1–129 作者链 K； PDB构建体 1–129； UniProt 1–129

SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT

ESCHERICHIA COLI

UniProt P0AC44

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
2	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致
3	蛋白异源复合物	异源复合物	蛋白 4	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT × 1 （P0AC41） SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT × 1 （P07014） SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT × 1 （P69054） FLAVIN-ADENINE DINUCLEOTIDE × 1 MALATE LIKE INTERMEDIATE × 1 SODIUM ION × 1 FE2/S2 (INORGANIC) CLUSTER × 1 IRON/SULFUR CLUSTER × 1 FE3-S4 CLUSTER × 1 PROTOPORPHYRIN IX CONTAINING FE × 1 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE × 1 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	DHSD_ECOLI
Isoform	—
PDB实体	4
链与序列区间	作者链 D； PDB构建体 1–115； UniProt 1–115 作者链 H； PDB构建体 1–115； UniProt 1–115 作者链 L； PDB构建体 1–115； UniProt 1–115

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	2wu5
沉积日期 deposition_date	2009-09-29
结构标题 title	Crystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhD His71Met mutant
关键词 keywords	;CELL INNER MEMBRANE, TRICARBOXYLIC ACID CYCLE, METAL-BINDING, TRANSMEMBRANE, TRANSPORT, FLAVOPROTEIN, OXIDOREDUCTASE, ELECTRON TRANSPORT ;; OXIDOREDUCTASE
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2wu5__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2wu5__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

2wu5__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	32.56 Å
Rg（电子密度）	33.35 Å
总 Rg	33.39 Å
原子数	8314
残基数	1053
排除体积	148470 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`2wu5__assembly_1__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`2wu5__assembly_2__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
3	1	`2wu5__assembly_3__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (13)

实体 1 Entity 1 polymer

描述 description	SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT
分子量 formula_weight	64502.8 kDa
EC 编号 ec_number	1.3.5.1, 1.3.99.1
来源方法 src_method	man
拷贝数 entity_count	3

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,E,I
原子数 atom_count	25164

MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNTHEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNRWNNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLMETAYATAVSANFRTESRGAHSRFDFPDRDDENWLCHSLYLPESESMTRRSVNMEPKLRPAFPPKIRTY

来源 Source

来源生物 organism	ESCHERICHIA COLI
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	ESCHERICHIA COLI

实体 2 Entity 2 polymer

描述 description	SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT
分子量 formula_weight	26800.9 kDa
EC 编号 ec_number	1.3.5.1, 1.3.99.1
来源方法 src_method	man
拷贝数 entity_count	3

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	B,F,J

MRLEFSIYRYNPDVDDAPRMQDYTLEADEGRDMMLLDALIQLKEKDPSLSFRRSCREGVCGSDGLNMNGKNGLACITPISALNQPGKKIVIRPLPGLPVIRDLVVDMGQFYAQYEKIKPYLLNNGQNPPAREHLQMPEQREKLDGLYECILCACCSTSCPSFWWNPDKFIGPAGLLAAYRFLIDSRDTETDSRLDGLSDAFSVFRCHSIMNCVSVCPKGLNPTRAIGHIKSMLLQRNA

来源 Source

来源生物 organism	ESCHERICHIA COLI
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	ESCHERICHIA COLI

实体 3 Entity 3 polymer

描述 description	SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT
分子量 formula_weight	14313.1 kDa
EC 编号 ec_number	1.3.5.1
来源方法 src_method	man
拷贝数 entity_count	3

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	C,G,K

MIRNVKKQRPVNLDLQTIRFPITAIASILHRVSGVITFVAVGILLWLLGTSLSSPEGFEQASAIMGSFFVKFIMWGILTALAYHVVVGIRHMMMDFGYLEETFEAGKRSAKISFVITVVLSLLAGVLVW

来源 Source

来源生物 organism	ESCHERICHIA COLI
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	ESCHERICHIA COLI

实体 4 Entity 4 polymer

描述 description	SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT
分子量 formula_weight	12867.5 kDa
EC 编号 ec_number	1.3.5.1
突变 mutation	YES
来源方法 src_method	man
拷贝数 entity_count	3

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	D,H,L

MVSNASALGRNGVHDFILVRATAIVLTLYIIYMVGFFATSGELTYEVWIGFFASAFTKVFTLLALFSILIMAWIGMWQVLTDYVKPLALRLMLQLVIVVALVVYVIYGFVVVWGV

来源 Source

来源生物 organism	ESCHERICHIA COLI
NCBI 分类编号 ncbi_taxonomy_id	562
宿主生物 host_organism	ESCHERICHIA COLI

实体 5 Entity 5 non-polymer

描述 description	FLAVIN-ADENINE DINUCLEOTIDE
分子量 formula_weight	785.5 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 6 Entity 6 non-polymer

描述 description	MALATE LIKE INTERMEDIATE
分子量 formula_weight	132.1 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 7 Entity 7 non-polymer

描述 description	SODIUM ION
分子量 formula_weight	23.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 8 Entity 8 non-polymer

描述 description	FE2/S2 (INORGANIC) CLUSTER
分子量 formula_weight	175.8 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 9 Entity 9 non-polymer

描述 description	IRON/SULFUR CLUSTER
分子量 formula_weight	351.6 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 10 Entity 10 non-polymer

描述 description	FE3-S4 CLUSTER
分子量 formula_weight	295.8 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 11 Entity 11 non-polymer

描述 description	PROTOPORPHYRIN IX CONTAINING FE
分子量 formula_weight	616.5 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 12 Entity 12 non-polymer

描述 description	2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE
分子量 formula_weight	235.3 kDa
来源方法 src_method	syn
拷贝数 entity_count	3

实体 13 Entity 13 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	222

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6. 折叠分类 (SCOP + CATH) 42 domains

SCOP 2.08 (18 domains)

结构域编号 domain_id	d2wu5a1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.3 — FAD/NAD(P)-binding domain
超家族 Superfamily superfamily	c.3.1 — FAD/NAD(P)-binding domain
家族 Family family	c.3.1.4 — Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain

结构域编号 domain_id	d2wu5a2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.168 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
超家族 Superfamily superfamily	d.168.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
家族 Family family	d.168.1.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

结构域编号 domain_id	d2wu5a3
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.7 — Spectrin repeat-like
超家族 Superfamily superfamily	a.7.3 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
家族 Family family	a.7.3.1 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain

结构域编号 domain_id	d2wu5b1
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamily	d.15.4 — 2Fe-2S ferredoxin-like
家族 Family family	d.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins

结构域编号 domain_id	d2wu5b2
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.1 — Globin-like
超家族 Superfamily superfamily	a.1.2 — alpha-helical ferredoxin
家族 Family family	a.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain

结构域编号 domain_id	d2wu5c_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamily	f.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family family	f.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

结构域编号 domain_id	d2wu5e1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.3 — FAD/NAD(P)-binding domain
超家族 Superfamily superfamily	c.3.1 — FAD/NAD(P)-binding domain
家族 Family family	c.3.1.4 — Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain

结构域编号 domain_id	d2wu5e2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.168 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
超家族 Superfamily superfamily	d.168.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
家族 Family family	d.168.1.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

结构域编号 domain_id	d2wu5e3
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.7 — Spectrin repeat-like
超家族 Superfamily superfamily	a.7.3 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
家族 Family family	a.7.3.1 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain

结构域编号 domain_id	d2wu5f1
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamily	d.15.4 — 2Fe-2S ferredoxin-like
家族 Family family	d.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins

结构域编号 domain_id	d2wu5f2
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.1 — Globin-like
超家族 Superfamily superfamily	a.1.2 — alpha-helical ferredoxin
家族 Family family	a.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain

结构域编号 domain_id	d2wu5g_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamily	f.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family family	f.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

结构域编号 domain_id	d2wu5i1
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.3 — FAD/NAD(P)-binding domain
超家族 Superfamily superfamily	c.3.1 — FAD/NAD(P)-binding domain
家族 Family family	c.3.1.4 — Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain

结构域编号 domain_id	d2wu5i2
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.168 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
超家族 Superfamily superfamily	d.168.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
家族 Family family	d.168.1.1 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

结构域编号 domain_id	d2wu5i3
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.7 — Spectrin repeat-like
超家族 Superfamily superfamily	a.7.3 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
家族 Family family	a.7.3.1 — Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain

结构域编号 domain_id	d2wu5j1
类 Class class	d — Alpha and beta proteins (a+b)
折叠类型 Fold fold	d.15 — beta-Grasp (ubiquitin-like)
超家族 Superfamily superfamily	d.15.4 — 2Fe-2S ferredoxin-like
家族 Family family	d.15.4.2 — 2Fe-2S ferredoxin domains from multidomain proteins

结构域编号 domain_id	d2wu5j2
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.1 — Globin-like
超家族 Superfamily superfamily	a.1.2 — alpha-helical ferredoxin
家族 Family family	a.1.2.1 — Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain

结构域编号 domain_id	d2wu5k_
类 Class class	f — Membrane and cell surface proteins and peptides
折叠类型 Fold fold	f.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamily	f.21.2 — Fumarate reductase respiratory complex transmembrane subunits
家族 Family family	f.21.2.2 — Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)

CATH v4.4 (24 domains)

结构域编号 domain_id	2wu5A01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily	60 — FAD/NAD(P)-binding domain

结构域编号 domain_id	2wu5A02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

结构域编号 domain_id	2wu5A03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain

结构域编号 domain_id	2wu5A04
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily	40 — succinate dehydrogenase protein domain

结构域编号 domain_id	2wu5B01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	10 — Roll
拓扑 Topology topology	20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily	30 — Beta-grasp domain

结构域编号 domain_id	2wu5B02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Alpha-helical ferredoxin

结构域编号 domain_id	2wu5C00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily	10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit

结构域编号 domain_id	2wu5D00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily	10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit

结构域编号 domain_id	2wu5E01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily	60 — FAD/NAD(P)-binding domain

结构域编号 domain_id	2wu5E02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

结构域编号 domain_id	2wu5E03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain

结构域编号 domain_id	2wu5E04
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily	40 — succinate dehydrogenase protein domain

结构域编号 domain_id	2wu5F01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	10 — Roll
拓扑 Topology topology	20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily	30 — Beta-grasp domain

结构域编号 domain_id	2wu5F02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Alpha-helical ferredoxin

结构域编号 domain_id	2wu5G00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily	10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit

结构域编号 domain_id	2wu5H00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily	10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit

结构域编号 domain_id	2wu5I01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	50 — 3-Layer(bba) Sandwich
拓扑 Topology topology	50 — FAD/NAD(P)-binding domain
同源超家族 H-superfamily homologous superfamily	60 — FAD/NAD(P)-binding domain

结构域编号 domain_id	2wu5I02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	90 — Alpha-Beta Complex
拓扑 Topology topology	700 — Flavocytochrome C3; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain

结构域编号 domain_id	2wu5I03
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	100 — Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain

结构域编号 domain_id	2wu5I04
类 Class class	4 — Few Secondary Structures
架构 Architecture architecture	10 — Irregular
拓扑 Topology topology	80 — Rhinovirus 14, subunit 4
同源超家族 H-superfamily homologous superfamily	40 — succinate dehydrogenase protein domain

结构域编号 domain_id	2wu5J01
类 Class class	3 — Alpha Beta
架构 Architecture architecture	10 — Roll
拓扑 Topology topology	20 — Ubiquitin-like (UB roll)
同源超家族 H-superfamily homologous superfamily	30 — Beta-grasp domain

结构域编号 domain_id	2wu5J02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1060 — Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
同源超家族 H-superfamily homologous superfamily	10 — Alpha-helical ferredoxin

结构域编号 domain_id	2wu5K00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily	10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit

结构域编号 domain_id	2wu5L00
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	1300 — 3 helical TM bundles of succinate and fumarate reductases
同源超家族 H-superfamily homologous superfamily	10 — Fumarate reductase/succinate dehydrogenase, transmembrane subunit

▶

晶胞边长 a length_a	120.060 Å
晶胞边长 b length_b	183.820 Å
晶胞边长 c length_c	203.420 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	12

空间群 space_group	P 21 21 21
空间群编号 int_tables_number	19
晶系 crystal_system	—

分辨率 resolution	2.803 Å
最低分辨率 resolution_low	46.827 Å
R 因子 r_factor	0.2153
R_work r_work	0.2134
R_free r_free	0.2515

Crystal structure of the E. coli succinate:quinone oxidoreductase (SQR) SdhD His71Met mutant

1. 蛋白身份与相关结构 Protein Identity & Related Structures

SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

SUCCINATE DEHYDROGENASE IRON-SULFUR SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

SUCCINATE DEHYDROGENASE CYTOCHROME B556 SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN SUBUNIT

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2wu5__assembly_1__model_1

2wu5__assembly_1__model_1 | I(q)

2wu5__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (13)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 polymer

聚合物 Polymer

来源 Source

实体 4 Entity 4 polymer

聚合物 Polymer

来源 Source

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 non-polymer

实体 8 Entity 8 non-polymer

实体 9 Entity 9 non-polymer

实体 10 Entity 10 non-polymer

实体 11 Entity 11 non-polymer

实体 12 Entity 12 non-polymer

实体 13 Entity 13 water

6. 折叠分类 (SCOP + CATH) 42 domains

SCOP 2.08 (18 domains)

CATH v4.4 (24 domains)

7. 引用文献 (1)