2wwe

Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

PHOSPHOINOSITIDE-3-KINASE, CLASS 2, GAMMA POLYPEPTIDE

HOMO SAPIENS

UniProt A1L3U0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name A1L3U0_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 24–127; UniProt 1203–1306

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2wwe
Deposition date deposition_date2009-10-22
Structure title titleCrystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma
Keywords keywordsPHOSPHOPROTEIN, NUCLEOTIDE-BINDING, KINASE, PIK3C2G, MEMBRANE, PX-DOMAIN, TRANSFERASE, ATP-BINDING, POLYMORPHISM, CLASS 2 PI3K; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2wwe__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2wwe__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2wwe__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)15.27 Å
Rg (electron density)14.01 Å
Total Rg15.12 Å
Atom count920
Residues111
Excluded volume16169 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2wwe__assembly_1__model_1 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd2wwea1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.189 — PX domain
Superfamily Superfamily superfamilyd.189.1 — PX domain
Family Family familyd.189.1.0 — automated matches
Domain ID domain_idd2wwea2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (1 domains)

Domain ID domain_id2wweA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology1520 — PX Domain
Homologous superfamily homologous superfamily10 — Phox-like domain
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7. Citations (1)