2x06

SULFOLACTATE DEHYDROGENASE FROM METHANOCALDOCOCCUS JANNASCHII

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

L-SULFOLACTATE DEHYDROGENASE

METHANOCALDOCOCCUS JANNASCHII

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 2	NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 water × 2	与蛋白数一致
2	蛋白同源多聚体	同源多聚体	蛋白 2	NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 water × 2	与蛋白数一致
3	蛋白同源多聚体	同源多聚体	蛋白 2	NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 water × 2	与蛋白数一致
4	蛋白同源多聚体	同源多聚体	蛋白 2	NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 2 water × 2	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	COMC_METJA
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–344； UniProt 1–344 作者链 B； PDB构建体 1–344； UniProt 1–344 作者链 C； PDB构建体 1–344； UniProt 1–344 作者链 D； PDB构建体 1–344； UniProt 1–344 作者链 E； PDB构建体 1–344； UniProt 1–344 作者链 F； PDB构建体 1–344； UniProt 1–344 作者链 G； PDB构建体 1–344； UniProt 1–344 作者链 H； PDB构建体 1–344； UniProt 1–344

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	2x06
沉积日期 deposition_date	2009-12-07
结构标题 title	SULFOLACTATE DEHYDROGENASE FROM METHANOCALDOCOCCUS JANNASCHII
关键词 keywords	;OXIDOREDUCTASE, HYPERTHERMOSTABLE, COENZYME M, METHANOGENS, COENZYME M BIOSYNTHESIS, PRO-S HYDROGEN TRANSFER, NAD-BINDING WITHOUT A ROSSMANN FOLD ;; OXIDOREDUCTASE
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2x06__assembly_4__model_1

Assembly 4 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2x06__assembly_4__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

2x06__assembly_4__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	26.82 Å
Rg（电子密度）	26.13 Å
总 Rg	26.81 Å
原子数	5334
残基数	670
排除体积	96443 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`2x06__assembly_1__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`2x06__assembly_2__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
3	1	`2x06__assembly_3__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
4	1	`2x06__assembly_4__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

描述 description	L-SULFOLACTATE DEHYDROGENASE
分子量 formula_weight	37831.4 kDa
EC 编号 ec_number	1.1.1.272
来源方法 src_method	man
拷贝数 entity_count	8

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H
原子数 atom_count	21878

MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGNINPKPDIKIVKESPATAVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIAGYYSELAMNQDMIGITITNTEPAMAPFGGKEKILGTNPIAIAFKGNKYKFSLDMATASIARGKILEALRKKIKIPEGCAVDKDGKPTTDPAKALEGCILPFGGPKGYGLALAIEMLSAIGGAEVGTKVKGTANPEERCTKGDLFIAINPEFFMGKEEFKRKVDELLDEIKNSEPAEGFEILIPGEIEERNKMKRKDGFEIDKNLYNQLKEICNELGLNIEDYIE

来源 Source

来源生物 organism	METHANOCALDOCOCCUS JANNASCHII
NCBI 分类编号 ncbi_taxonomy_id	2190
宿主生物 host_organism	ESCHERICHIA COLI

实体 2 Entity 2 non-polymer

描述 description	NICOTINAMIDE-ADENINE-DINUCLEOTIDE
分子量 formula_weight	663.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	8

实体 3 Entity 3 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	500

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6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (8 domains)

结构域编号 domain_id	d2x06a_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

结构域编号 domain_id	d2x06b_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

结构域编号 domain_id	d2x06c_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

结构域编号 domain_id	d2x06d_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

结构域编号 domain_id	d2x06e_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

结构域编号 domain_id	d2x06f_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

结构域编号 domain_id	d2x06g_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

结构域编号 domain_id	d2x06h_
类 Class class	c — Alpha and beta proteins (a/b)
折叠类型 Fold fold	c.122 — L-sulfolactate dehydrogenase-like
超家族 Superfamily superfamily	c.122.1 — L-sulfolactate dehydrogenase-like
家族 Family family	c.122.1.1 — L-sulfolactate dehydrogenase-like

CATH v4.4 (16 domains)

结构域编号 domain_id	2x06A01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06A02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

结构域编号 domain_id	2x06B01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06B02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

结构域编号 domain_id	2x06C01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06C02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

结构域编号 domain_id	2x06D01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06D02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

结构域编号 domain_id	2x06E01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06E02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

结构域编号 domain_id	2x06F01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06F02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

结构域编号 domain_id	2x06G01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06G02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

结构域编号 domain_id	2x06H01
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	10 — Orthogonal Bundle
拓扑 Topology topology	1530 — Hypothetical Oxidoreductase Yiak; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	10 — Malate/L-lactate/L-sulpholactate dehydrogenase, four-helix barrel

结构域编号 domain_id	2x06H02
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	1370 — Ribosomal Protein S8; Chain: A, domain 1
同源超家族 H-superfamily homologous superfamily	60 — Malate/L-lactate/L-sulpholactate dehydrogenase, NADPH binding domain

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晶胞边长 a length_a	80.930 Å
晶胞边长 b length_b	203.710 Å
晶胞边长 c length_c	100.050 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	112.05 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	16

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	2.500 Å
最低分辨率 resolution_low	32.831 Å
R 因子 r_factor	0.1567
R_work r_work	0.1530
R_free r_free	0.2242

SULFOLACTATE DEHYDROGENASE FROM METHANOCALDOCOCCUS JANNASCHII

1. 蛋白身份与相关结构 Protein Identity & Related Structures

L-SULFOLACTATE DEHYDROGENASE

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2x06__assembly_4__model_1

2x06__assembly_4__model_1 | I(q)

2x06__assembly_4__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (8 domains)

CATH v4.4 (16 domains)

7. 引用文献 (3)

SULFOLACTATE DEHYDROGENASE FROM METHANOCALDOCOCCUS JANNASCHII

1. 蛋白身份与相关结构 Protein Identity & Related Structures

L-SULFOLACTATE DEHYDROGENASE

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

2x06__assembly_4__model_1

2x06__assembly_4__model_1 | I(q)

2x06__assembly_4__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 24 domains

SCOP 2.08 (8 domains)

CATH v4.4 (16 domains)

7. 引用文献 (3)