ESCHERICHIA COLI
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白单体 | 单体 | 蛋白 1 | (1R,3R,4S)-4-[({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)AMINO]CYCLOHEXANE-1,3-DICARBOXYLIC ACID × 1 DIMETHYL SULFOXIDE × 3 SULFATE ION × 4 CHLORIDE ION × 1 water × 1 | 与蛋白数一致 |
| UniProt名称 | MURD_ECO57 |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 1–437； UniProt 2–438 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 2xpc |
| 沉积日期 deposition_date | 2010-08-26 |
| 结构标题 title | Second-generation sulfonamide inhibitors of MurD: Activity optimisation with conformationally rigid analogues of D-glutamic acid |
| 关键词 keywords | LIGASE, CELL CYCLE, CELL DIVISION, CELL SHAPE, CELL WALL BIOGENESIS/DEGRADATION, LIGASE SYNTHESIS; LIGASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 23.74 Å |
| Rg（电子密度） | 22.62 Å |
| 总 Rg | 23.45 Å |
| 原子数 | 3348 |
| 残基数 | 434 |
| 排除体积 | 59290 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d2xpca1 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.5 — MurCD N-terminal domain |
| 超家族 Superfamily superfamily | c.5.1 — MurCD N-terminal domain |
| 家族 Family family | c.5.1.0 — automated matches |
| 结构域编号 domain_id | d2xpca2 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.72 — Ribokinase-like |
| 超家族 Superfamily superfamily | c.72.2 — MurD-like peptide ligases, catalytic domain |
| 家族 Family family | c.72.2.1 — MurCDEF |
| 结构域编号 domain_id | d2xpca3 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.59 — MurD-like peptide ligases, peptide-binding domain |
| 超家族 Superfamily superfamily | c.59.1 — MurD-like peptide ligases, peptide-binding domain |
| 家族 Family family | c.59.1.0 — automated matches |
| 结构域编号 domain_id | d2xpca4 |
| 类 Class class | l — Artifacts |
| 折叠类型 Fold fold | l.1 — Tags |
| 超家族 Superfamily superfamily | l.1.1 — Tags |
| 家族 Family family | l.1.1.1 — Tags |
| 结构域编号 domain_id | 2xpcA01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 720 — NAD(P)-binding Rossmann-like Domain |
| 结构域编号 domain_id | 2xpcA02 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 1190 — UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase |
| 同源超家族 H-superfamily homologous superfamily | 10 — Mur-like, catalytic domain |
| 结构域编号 domain_id | 2xpcA03 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 90 — Alpha-Beta Complex |
| 拓扑 Topology topology | 190 — Protein-Tyrosine Phosphatase; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 20 — Mur ligase, C-terminal domain |