2yii

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

PHENYLALANINE AMMONIA-LYASE

TAXUS WALLICHIANA VAR. CHINENSIS

UniProt Q68G84

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白同源多聚体 同源多聚体 蛋白 4 BETA-MERCAPTOETHANOL × 8 FORMIC ACID × 4 GLYCEROL × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q68G83_TAXWC
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 21–705; UniProt 1–687 作者链 B; PDB构建体 21–705; UniProt 1–687 作者链 C; PDB构建体 21–705; UniProt 1–687 作者链 D; PDB构建体 21–705; UniProt 1–687

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2yii
沉积日期 deposition_date2011-05-13
结构标题 titleManipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of MIO-dependent enzymes from structure-guided directed evolution
关键词 keywordsLYASE; LYASE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

2yii__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

2yii__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

2yii__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)40.90 Å
Rg(电子密度)40.23 Å
总 Rg40.69 Å
原子数20131
残基数2581
排除体积360840 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 2yii__assembly_1__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (5)

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6. 折叠分类 (SCOP + CATH) 16 domains

SCOP 2.08 (4 domains)

结构域编号 domain_idd2yiia_
类 Class classa — All alpha proteins
折叠类型 Fold folda.127 — L-aspartase-like
超家族 Superfamily superfamilya.127.1 — L-aspartase-like
家族 Family familya.127.1.0 — automated matches
结构域编号 domain_idd2yiib_
类 Class classa — All alpha proteins
折叠类型 Fold folda.127 — L-aspartase-like
超家族 Superfamily superfamilya.127.1 — L-aspartase-like
家族 Family familya.127.1.0 — automated matches
结构域编号 domain_idd2yiic_
类 Class classa — All alpha proteins
折叠类型 Fold folda.127 — L-aspartase-like
超家族 Superfamily superfamilya.127.1 — L-aspartase-like
家族 Family familya.127.1.0 — automated matches
结构域编号 domain_idd2yiid_
类 Class classa — All alpha proteins
折叠类型 Fold folda.127 — L-aspartase-like
超家族 Superfamily superfamilya.127.1 — L-aspartase-like
家族 Family familya.127.1.0 — automated matches

CATH v4.4 (12 domains)

结构域编号 domain_id2yiiA01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology275 — Fumarase C; Chain B, domain 1
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (N-terminal domain)
结构域编号 domain_id2yiiA02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology200 — Fumarase C; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (Central domain)
结构域编号 domain_id2yiiA03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology274 — Enzyme I; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily20 — Phenylalanine ammonia-lyase 1; domain 3
结构域编号 domain_id2yiiB01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology275 — Fumarase C; Chain B, domain 1
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (N-terminal domain)
结构域编号 domain_id2yiiB02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology200 — Fumarase C; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (Central domain)
结构域编号 domain_id2yiiB03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology274 — Enzyme I; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily20 — Phenylalanine ammonia-lyase 1; domain 3
结构域编号 domain_id2yiiC01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology275 — Fumarase C; Chain B, domain 1
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (N-terminal domain)
结构域编号 domain_id2yiiC02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology200 — Fumarase C; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (Central domain)
结构域编号 domain_id2yiiC03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology274 — Enzyme I; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily20 — Phenylalanine ammonia-lyase 1; domain 3
结构域编号 domain_id2yiiD01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology275 — Fumarase C; Chain B, domain 1
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (N-terminal domain)
结构域编号 domain_id2yiiD02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology200 — Fumarase C; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily10 — Fumarase/aspartase (Central domain)
结构域编号 domain_id2yiiD03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology274 — Enzyme I; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily20 — Phenylalanine ammonia-lyase 1; domain 3
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7. 引用文献 (1)