物种未注明
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白同源多聚体 | 同源多聚体 | 蛋白 2 | 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 ;(2~{S})-2-azanyl-1-[(1~{S},3~{S},5~{S})-3-(iminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(5~{R},7~{S})-3-oxidanyl-1-ad amantyl]ethanone ; × 2 water × 2 | 与蛋白数一致 |
| UniProt名称 | DPP4_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 1–728； UniProt 39–766 作者链 B； PDB构建体 1–728； UniProt 39–766 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 3bjm |
| 沉积日期 deposition_date | 2007-12-04 |
| 结构标题 title | Crystal structure of human DPP-IV in complex with (1S,3S, 5S)-2-[(2S)-2-AMINO-2-(3-HYDROXYTRICYCLO[3.3.1.13,7]DEC-1- YL)ACETYL]-2-AZABICYCLO[3.1.0]HEXANE-3-CARBONITRILE (CAS), (1S,3S,5S)-2-((2S)-2-AMINO-2-(3-HYDROXYADAMANTAN-1- YL)ACETYL)-2-AZABICYCLO[3.1.0]HEXANE-3-CARBONITRILE (IUPAC), OR BMS-477118 |
| 关键词 keywords | ;EXOPEPTIDASE, ALPHA/BETA HYDROLASE FOLD, BETA BARREL, BETA PROPELLER, DPP4, DIMER, PROTEIN:INHIBITOR COMPLEX, Aminopeptidase, Glycoprotein, Membrane, Protease, Secreted, Serine protease, Signal-anchor, Transmembrane, HYDROLASE ;; HYDROLASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 39.35 Å |
| Rg（电子密度） | 39.00 Å |
| 总 Rg | 39.50 Å |
| 原子数 | 12084 |
| 残基数 | 1456 |
| 排除体积 | 214150 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d3bjma1 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.70 — 8-bladed beta-propeller |
| 超家族 Superfamily superfamily | b.70.3 — DPP6 N-terminal domain-like |
| 家族 Family family | b.70.3.1 — DPP6 N-terminal domain-like |
| 结构域编号 domain_id | d3bjma2 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.69 — alpha/beta-Hydrolases |
| 超家族 Superfamily superfamily | c.69.1 — alpha/beta-Hydrolases |
| 家族 Family family | c.69.1.24 — DPP6 catalytic domain-like |
| 结构域编号 domain_id | d3bjmb1 |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.70 — 8-bladed beta-propeller |
| 超家族 Superfamily superfamily | b.70.3 — DPP6 N-terminal domain-like |
| 家族 Family family | b.70.3.1 — DPP6 N-terminal domain-like |
| 结构域编号 domain_id | d3bjmb2 |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.69 — alpha/beta-Hydrolases |
| 超家族 Superfamily superfamily | c.69.1 — alpha/beta-Hydrolases |
| 家族 Family family | c.69.1.24 — DPP6 catalytic domain-like |
| 结构域编号 domain_id | 3bjmA01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 1820 — Alpha/Beta hydrolase fold, catalytic domain |
| 结构域编号 domain_id | 3bjmA02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 140 — 8 Propeller |
| 拓扑 Topology topology | 10 — Methanol Dehydrogenase; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 30 — Dipeptidylpeptidase IV, N-terminal domain |
| 结构域编号 domain_id | 3bjmB01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 1820 — Alpha/Beta hydrolase fold, catalytic domain |
| 结构域编号 domain_id | 3bjmB02 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 140 — 8 Propeller |
| 拓扑 Topology topology | 10 — Methanol Dehydrogenase; Chain A |
| 同源超家族 H-superfamily homologous superfamily | 30 — Dipeptidylpeptidase IV, N-terminal domain |