SAXSdb — 3blw

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Isocitrate dehydrogenase [NAD] subunit 1

Saccharomyces cerevisiae

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 8	Isocitrate dehydrogenase [NAD] subunit 2 × 4 （P28241） CITRATE ANION × 4 ADENOSINE MONOPHOSPHATE × 4	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 8	Isocitrate dehydrogenase [NAD] subunit 2 × 4 （P28241） CITRATE ANION × 4 ADENOSINE MONOPHOSPHATE × 4	Consistent with protein count
3	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 2 × 2 （P28241） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count
4	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 2 × 2 （P28241） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count
5	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 2 × 2 （P28241） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count
6	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 2 × 2 （P28241） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	IDH1_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–349； UniProt 12–360 Author chain C； PDBConstruct 1–349； UniProt 12–360 Author chain E； PDBConstruct 1–349； UniProt 12–360 Author chain G； PDBConstruct 1–349； UniProt 12–360 Author chain I； PDBConstruct 1–349； UniProt 12–360 Author chain K； PDBConstruct 1–349； UniProt 12–360 Author chain M； PDBConstruct 1–349； UniProt 12–360 Author chain O； PDBConstruct 1–349； UniProt 12–360

Isocitrate dehydrogenase [NAD] subunit 2

Saccharomyces cerevisiae

UniProt P28241

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 8	Isocitrate dehydrogenase [NAD] subunit 1 × 4 （P28834） CITRATE ANION × 4 ADENOSINE MONOPHOSPHATE × 4	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 8	Isocitrate dehydrogenase [NAD] subunit 1 × 4 （P28834） CITRATE ANION × 4 ADENOSINE MONOPHOSPHATE × 4	Consistent with protein count
3	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 1 × 2 （P28834） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count
4	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 1 × 2 （P28834） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count
5	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 1 × 2 （P28834） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count
6	Protein heterocomplex	Heteromer	Protein 4	Isocitrate dehydrogenase [NAD] subunit 1 × 2 （P28834） CITRATE ANION × 2 ADENOSINE MONOPHOSPHATE × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	IDH2_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–354； UniProt 16–369 Author chain D； PDBConstruct 1–354； UniProt 16–369 Author chain F； PDBConstruct 1–354； UniProt 16–369 Author chain H； PDBConstruct 1–354； UniProt 16–369 Author chain J； PDBConstruct 1–354； UniProt 16–369 Author chain L； PDBConstruct 1–354； UniProt 16–369 Author chain N； PDBConstruct 1–354； UniProt 16–369 Author chain P； PDBConstruct 1–354； UniProt 16–369

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	3blw
Deposition date deposition_date	2007-12-11
Structure title title	Yeast Isocitrate Dehydrogenase with Citrate and AMP Bound in the Regulatory Subunits
Keywords keywords	;TCA cycle, oxidative metabolism, allostery, dehydrogenase, decarboxylase, Allosteric enzyme, Magnesium, Manganese, Metal-binding, Mitochondrion, NAD, Oxidoreductase, RNA-binding, Transit peptide, Tricarboxylic acid cycle, Phosphoprotein ;; OXIDOREDUCTASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3blw__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3blw__assembly_3__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

3blw__assembly_3__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	37.93 Å
Rg (electron density)	37.26 Å
Total Rg	37.63 Å
Atom count	10428
Residues	1361
Excluded volume	186190 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`3blw__assembly_1__model_1`	octameric （8）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`3blw__assembly_2__model_1`	octameric （8）	Success	4.1.3-1-20251215 (887e7ef)	View Download
3	1	`3blw__assembly_3__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
4	1	`3blw__assembly_4__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
5	1	`3blw__assembly_5__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
6	1	`3blw__assembly_6__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Description description	Isocitrate dehydrogenase [NAD] subunit 1
Molecular weight formula_weight	38076.4 kDa
EC 编号 ec_number	1.1.1.41
Source method src_method	man
Copy count entity_count	8

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,C,E,G,I,K,M,O
Atom count atom_count	41694

ATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli BL21(DE3)

Entity 2 Entity 2 polymer

Description description	Isocitrate dehydrogenase [NAD] subunit 2
Molecular weight formula_weight	37839.0 kDa
EC 编号 ec_number	1.1.1.41
Source method src_method	man
Copy count entity_count	8

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,D,F,H,J,L,N,P

ATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	Escherichia coli BL21(DE3)

Entity 3 Entity 3 non-polymer

Description description	CITRATE ANION
Molecular weight formula_weight	189.1 kDa
Source method src_method	syn
Copy count entity_count	8

Entity 4 Entity 4 non-polymer

Description description	ADENOSINE MONOPHOSPHATE
Molecular weight formula_weight	347.2 kDa
Source method src_method	syn
Copy count entity_count	8

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Unit-cell length a length_a	113.157 Å
Unit-cell length b length_b	116.346 Å
Unit-cell length c length_c	163.620 Å
Unit-cell angle α angle_alpha	98.96 °
Unit-cell angle β angle_beta	110.23 °
Unit-cell angle γ angle_gamma	106.63 °
Molecules per unit cell Z z_pdb	8

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	4.300 Å
Low-resolution limit resolution_low	49.383 Å
R factor r_factor	0.2758
R_work r_work	0.2739
R_free r_free	0.3106

Yeast Isocitrate Dehydrogenase with Citrate and AMP Bound in the Regulatory Subunits

1. Protein Identity and Related Structures Protein Identity & Related Structures

Isocitrate dehydrogenase [NAD] subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Isocitrate dehydrogenase [NAD] subunit 2

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

3blw__assembly_3__model_1

3blw__assembly_3__model_1 | I(q)

3blw__assembly_3__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 non-polymer

7. Citations (1)

Yeast Isocitrate Dehydrogenase with Citrate and AMP Bound in the Regulatory Subunits

1. Protein Identity and Related Structures Protein Identity & Related Structures

Isocitrate dehydrogenase [NAD] subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Isocitrate dehydrogenase [NAD] subunit 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

3blw__assembly_3__model_1

3blw__assembly_3__model_1 | I(q)

3blw__assembly_3__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 non-polymer

7. Citations (1)