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3bx7

Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4

Homo sapiens

UniProt P16410

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 ENGINEERED HUMAN LIPOCALIN 2 × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5xj3 5xj3 5xj3 5xj3

4 assemblies

Homodimer
2x44 3osk

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ah1 1h6e 1i85 1i8l 1i8l 3bx7 5ggv 5tru 5tru 6rp8 6rp8 6rpj

27 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CTLA4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain C； PDBConstruct 1–124； UniProt 38–161

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3bx7
Deposition date deposition_date2008-01-11
Structure title titleEngineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4
Keywords keywords;PROTEIN DESIGN, PROTEIN-PROTEIN COMPLEX, GLYCOPROTEIN, IMMUNOGLOBULIN DOMAIN, POLYMORPHISM, TRANSMEMBRANE PROTEIN, DE NOVO PROTEIN, PROTEIN BINDING ;; DE NOVO PROTEIN, PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3bx7__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3bx7__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3bx7__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.85 Å
Rg (electron density)34.51 Å
Total Rg34.85 Å
Atom count4574
Residues586
Excluded volume81697 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3bx7__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd3bx7a_
Class classb — All beta proteins
Fold Fold foldb.60 — Lipocalins
Superfamily Superfamily superfamilyb.60.1 — Lipocalins
Family Family familyb.60.1.1 — Retinol binding protein-like
Domain ID domain_idd3bx7c_
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.1 — V set domains (antibody variable domain-like)

CATH v4.4 (2 domains)

Domain ID domain_id3bx7A00
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology128 — Lipocalin
Homologous superfamily homologous superfamily20 — Calycin beta-barrel core domain
Domain ID domain_id3bx7C00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
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7. Citations (1)