3c7k

Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Guanine nucleotide-binding protein G(o) subunit alpha

Mus musculus

UniProt P18872

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 2 Regulator of G-protein signaling 16 × 1 (P97428) MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 2 Regulator of G-protein signaling 16 × 1 (P97428) MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 GNAO_MOUSE
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–333; UniProt 22–354 作者链 C; PDB构建体 1–333; UniProt 22–354

Regulator of G-protein signaling 16

Mus musculus

UniProt P97428

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 2 Guanine nucleotide-binding protein G(o) subunit alpha × 1 (P18872) MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 1 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 2 Guanine nucleotide-binding protein G(o) subunit alpha × 1 (P18872) MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 water × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RGS16_MOUSE
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 2–129; UniProt 53–180 作者链 D; PDB构建体 2–129; UniProt 53–180

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id3c7k
沉积日期 deposition_date2008-02-07
结构标题 titleMolecular architecture of Galphao and the structural basis for RGS16-mediated deactivation
关键词 keywords;RGS, Galpha, AlF4 heterotrimeric G-protein GAP, GTP-binding, Lipoprotein, Myristate, Nucleotide-binding, Palmitate, Transducer, Phosphoprotein, Signal transduction inhibitor, SIGNALING PROTEIN ;; SIGNALING PROTEIN
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

3c7k__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

3c7k__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

3c7k__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)23.01 Å
Rg(电子密度)22.13 Å
总 Rg22.97 Å
原子数3443
残基数424
排除体积61091 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 3c7k__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 3c7k__assembly_2__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (6)

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6. 折叠分类 (SCOP + CATH) 10 domains

SCOP 2.08 (2 domains)

结构域编号 domain_idd3c7kb_
类 Class classa — All alpha proteins
折叠类型 Fold folda.91 — Regulator of G-protein signaling, RGS
超家族 Superfamily superfamilya.91.1 — Regulator of G-protein signaling, RGS
家族 Family familya.91.1.1 — Regulator of G-protein signaling, RGS
结构域编号 domain_idd3c7kd_
类 Class classa — All alpha proteins
折叠类型 Fold folda.91 — Regulator of G-protein signaling, RGS
超家族 Superfamily superfamilya.91.1 — Regulator of G-protein signaling, RGS
家族 Family familya.91.1.1 — Regulator of G-protein signaling, RGS

CATH v4.4 (8 domains)

结构域编号 domain_id3c7kA01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id3c7kA02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology400 — GI Alpha 1, domain 2-like
同源超家族 H-superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
结构域编号 domain_id3c7kB01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology196 — Regulator of G-protein Signalling 4; domain 1
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id3c7kB02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology167 — Regulator of G-protein Signalling 4; domain 2
同源超家族 H-superfamily homologous superfamily10 — Regulator of G-protein Signalling 4, domain 2
结构域编号 domain_id3c7kC01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
结构域编号 domain_id3c7kC02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology400 — GI Alpha 1, domain 2-like
同源超家族 H-superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
结构域编号 domain_id3c7kD01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology196 — Regulator of G-protein Signalling 4; domain 1
同源超家族 H-superfamily homologous superfamily10 —
结构域编号 domain_id3c7kD02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology167 — Regulator of G-protein Signalling 4; domain 2
同源超家族 H-superfamily homologous superfamily10 — Regulator of G-protein Signalling 4, domain 2
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7. 引用文献 (1)