Mus musculus
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白单体 | 单体 | 蛋白 1 | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol × 1 GLYCEROL × 3 water × 1 | 与蛋白数一致 |
| UniProt名称 | DYR_MOUSE |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 1–186； UniProt 2–187 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 3d80 |
| 沉积日期 deposition_date | 2008-05-22 |
| 结构标题 title | Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine |
| 关键词 keywords | mouse holo enzyme ternary ligand complex dihydrofolate reductase, NADP, One-carbon metabolism, Oxidoreductase; OXIDOREDUCTASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 17.25 Å |
| Rg（电子密度） | 16.06 Å |
| 总 Rg | 17.22 Å |
| 原子数 | 1608 |
| 残基数 | 186 |
| 排除体积 | 28713 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d3d80a_ |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.71 — Dihydrofolate reductase-like |
| 超家族 Superfamily superfamily | c.71.1 — Dihydrofolate reductase-like |
| 家族 Family family | c.71.1.1 — Dihydrofolate reductases |
| 结构域编号 domain_id | 3d80A00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 430 — Dihydrofolate Reductase, subunit A |
| 同源超家族 H-superfamily homologous superfamily | 10 — Dihydrofolate Reductase, subunit A |