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3hp1

Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Deoxycytidine kinase

Homo sapiens

UniProt P27707

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ADENOSINE-5'-DIPHOSPHATE × 2 L-deoxythymidine × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3ipx 3ipy 3ipy

3 assemblies

Homodimer
1p5z 1p60 1p61 1p62 2a2z 2a2z 2a30 2a30 2a7q 2no0 2no1 2no6

72 assemblies; showing the first 12

Homotetramer
1p60 1p60 2no0 2no0 2no1 2no1 2no6 2no6 2no9 2no9 2noa 2noa

13 assemblies; showing the first 12

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name DCK_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 21–280； UniProt 1–260

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3hp1
Deposition date deposition_date2009-06-03
Structure title titleCrystal structure of human dCK R104M/D133A in complex with L-dT and ADP
Keywords keywords;dCK, L-dT, DM-dCK, dCK Structure Function Studies, Nucleoside Kinase, Protein-NA complex, dCK drug designing, ATP-binding, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Transferase ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3hp1__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3hp1__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3hp1__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.03 Å
Rg (electron density)25.48 Å
Total Rg26.25 Å
Atom count3764
Residues452
Excluded volume66789 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3hp1__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd3hp1a_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.1 — Nucleotide and nucleoside kinases

CATH v4.4 (1 domains)

Domain ID domain_id3hp1A00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)