Homo sapiens
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白同源多聚体 | 同源多聚体 | 蛋白 3 | (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid × 3 3-(4-HYDROXY-PHENYL)PYRUVIC ACID × 3 CHLORIDE ION × 8 (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one × 1 water × 3 | 与蛋白数一致 |
| UniProt名称 | MIF_HUMAN |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 1–114； UniProt 2–115 作者链 B； PDB构建体 1–114； UniProt 2–115 作者链 C； PDB构建体 1–114； UniProt 2–115 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 3ijj |
| 沉积日期 deposition_date | 2009-08-04 |
| 结构标题 title | Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer) |
| 关键词 keywords | allosteric inhibition, Cytokine, Immune response, Inflammatory response, Innate immunity, Isomerase, Phosphoprotein, Secreted; ISOMERASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 19.89 Å |
| Rg（电子密度） | 18.63 Å |
| 总 Rg | 19.54 Å |
| 原子数 | 2634 |
| 残基数 | 342 |
| 排除体积 | 46966 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d3ijja_ |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.80 — Tautomerase/MIF |
| 超家族 Superfamily superfamily | d.80.1 — Tautomerase/MIF |
| 家族 Family family | d.80.1.3 — MIF-related |
| 结构域编号 domain_id | d3ijjb_ |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.80 — Tautomerase/MIF |
| 超家族 Superfamily superfamily | d.80.1 — Tautomerase/MIF |
| 家族 Family family | d.80.1.3 — MIF-related |
| 结构域编号 domain_id | d3ijjc_ |
| 类 Class class | d — Alpha and beta proteins (a+b) |
| 折叠类型 Fold fold | d.80 — Tautomerase/MIF |
| 超家族 Superfamily superfamily | d.80.1 — Tautomerase/MIF |
| 家族 Family family | d.80.1.3 — MIF-related |
| 结构域编号 domain_id | 3ijjA00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 429 — Macrophage Migration Inhibitory Factor |
| 同源超家族 H-superfamily homologous superfamily | 10 — Macrophage Migration Inhibitory Factor |
| 结构域编号 domain_id | 3ijjB00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 429 — Macrophage Migration Inhibitory Factor |
| 同源超家族 H-superfamily homologous superfamily | 10 — Macrophage Migration Inhibitory Factor |
| 结构域编号 domain_id | 3ijjC00 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 429 — Macrophage Migration Inhibitory Factor |
| 同源超家族 H-superfamily homologous superfamily | 10 — Macrophage Migration Inhibitory Factor |