Alternate Binding Modes Observed for the E- and Z-isomers of 2,4-Diaminofuro[2,3d]pyrimidines as Ternary Complexes with NADPH and Mouse Dihydrofolate Reductase
Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures
Alternate Binding Modes Observed for the E- and Z-isomers of 2,4-Diaminofuro[2,3d]pyrimidines as Ternary Complexes with NADPH and Mouse Dihydrofolate Reductase
关键词 keywords
PROTEIN LIGAND COFACTOR TERNARY COMPLEX, NADP, ONE-CARBON METABOLISM, OXIDOREDUCTASE; OXIDOREDUCTASE
实验方法 method
X-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles
;Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
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