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3l89

Human Adenovirus type 21 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Fiber protein

Human adenovirus 21

UniProt Q2KS96

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Membrane cofactor protein × 3 （P15529） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 6 Membrane cofactor protein × 3 （P15529） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 6 Membrane cofactor protein × 3 （P15529） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 6 Membrane cofactor protein × 3 （P15529） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
3l88 3l88 3l88 3l88

4 assemblies

Heteromeric or nucleic-acid complex
3l89 3l89 3l89 3l89

4 assemblies

View Construct and Data Evidence
UniProt name Q2KS96_9ADEN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–201； UniProt 123–323 Author chain B； PDBConstruct 1–201； UniProt 123–323 Author chain C； PDBConstruct 1–201； UniProt 123–323 Author chain D； PDBConstruct 1–201； UniProt 123–323 Author chain E； PDBConstruct 1–201； UniProt 123–323 Author chain F； PDBConstruct 1–201； UniProt 123–323 Author chain G； PDBConstruct 1–201； UniProt 123–323 Author chain H； PDBConstruct 1–201； UniProt 123–323 Author chain I； PDBConstruct 1–201； UniProt 123–323 Author chain J； PDBConstruct 1–201； UniProt 123–323 Author chain K； PDBConstruct 1–201； UniProt 123–323 Author chain L； PDBConstruct 1–201； UniProt 123–323

Membrane cofactor protein

Homo sapiens

UniProt P15529

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Fiber protein × 3 （Q2KS96） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 6 Fiber protein × 3 （Q2KS96） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 6 Fiber protein × 3 （Q2KS96） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 6 Fiber protein × 3 （Q2KS96） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ckl 1ckl 1ckl 1ckl 1ckl 1ckl 2o39 2o39 3inb 3l89 3l89 3l89

17 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MCP_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain M； PDBConstruct 1–126； UniProt 35–160 Author chain N； PDBConstruct 1–126； UniProt 35–160 Author chain O； PDBConstruct 1–126； UniProt 35–160 Author chain P； PDBConstruct 1–126； UniProt 35–160 Author chain Q； PDBConstruct 1–126； UniProt 35–160 Author chain R； PDBConstruct 1–126； UniProt 35–160 Author chain S； PDBConstruct 1–126； UniProt 35–160 Author chain T； PDBConstruct 1–126； UniProt 35–160 Author chain U； PDBConstruct 1–126； UniProt 35–160 Author chain V； PDBConstruct 1–126； UniProt 35–160 Author chain W； PDBConstruct 1–126； UniProt 35–160 Author chain X； PDBConstruct 1–126； UniProt 35–160

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3l89
Deposition date deposition_date2009-12-30
Structure title titleHuman Adenovirus type 21 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)
Keywords keywords;Adenovirus, Fiber Knob, Viral Protein, Membrane cofactor protein, MCP, virus receptor complex, SCR, Short consensus repeat, CCP, complement control protein, Complement pathway, Glycoprotein, Host-virus interaction, Immune response, Innate immunity, Sushi2, VIRAL PROTEIN-PROTEIN BINDING complex ;; VIRAL PROTEIN/PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3l89__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3l89__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3l89__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）32.67 Å
Rg (electron density)31.66 Å
Total Rg32.27 Å
Atom count7267
Residues928
Excluded volume129270 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3l89__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3l89__assembly_2__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 3l89__assembly_3__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 3l89__assembly_4__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 36 domains

CATH v4.4 (36 domains)

Domain ID domain_id3l89A00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89B00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89C00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89D00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89E00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89F00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89G00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89H00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89I00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89J00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89K00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89L00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology90 — Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)
Homologous superfamily homologous superfamily10 — Adenovirus pIV-related, attachment domain
Domain ID domain_id3l89M01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89M02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89N01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89N02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89O01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89O02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89P01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89P02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89Q01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89Q02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89R01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89R02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89S01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89S02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89T01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89T02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89U01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89U02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89V01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89V02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89W01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89W02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89X01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id3l89X02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
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7. Citations (1)