3n59

Type II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate

Method: X-RAY DIFFRACTION

1. 蛋白身份与相关结构 Protein Identity & Related Structures

3-dehydroquinate dehydratase

Mycobacterium tuberculosis

UniProt P0A4Z6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白同源多聚体 同源多聚体 蛋白 12 CHLORIDE ION × 12 (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid × 2 water × 12 与蛋白数一致
2 蛋白同源多聚体 同源多聚体 蛋白 12 CHLORIDE ION × 12 water × 12 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 AROQ_MYCTU
Isoform
PDB实体 1
链与序列区间 作者链 A; PDB构建体 26–172; UniProt 1–147 作者链 B; PDB构建体 26–172; UniProt 1–147 作者链 C; PDB构建体 26–172; UniProt 1–147 作者链 D; PDB构建体 26–172; UniProt 1–147 作者链 E; PDB构建体 26–172; UniProt 1–147 作者链 F; PDB构建体 26–172; UniProt 1–147 作者链 G; PDB构建体 26–172; UniProt 1–147 作者链 H; PDB构建体 26–172; UniProt 1–147 作者链 I; PDB构建体 26–172; UniProt 1–147 作者链 J; PDB构建体 26–172; UniProt 1–147 作者链 K; PDB构建体 26–172; UniProt 1–147 作者链 L; PDB构建体 26–172; UniProt 1–147 作者链 M; PDB构建体 26–172; UniProt 1–147 作者链 N; PDB构建体 26–172; UniProt 1–147 作者链 O; PDB构建体 26–172; UniProt 1–147 作者链 P; PDB构建体 26–172; UniProt 1–147 作者链 Q; PDB构建体 26–172; UniProt 1–147 作者链 R; PDB构建体 26–172; UniProt 1–147 作者链 S; PDB构建体 26–172; UniProt 1–147 作者链 T; PDB构建体 26–172; UniProt 1–147 作者链 U; PDB构建体 26–172; UniProt 1–147 作者链 V; PDB构建体 26–172; UniProt 1–147 作者链 W; PDB构建体 26–172; UniProt 1–147 作者链 X; PDB构建体 26–172; UniProt 1–147

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

2. 结构基本信息 2. Structure Basics

条目编号 entry_id3n59
沉积日期 deposition_date2010-05-24
结构标题 titleType II dehydroquinase from Mycobacterium Tuberculosis complexed with 3-dehydroshikimate
关键词 keywords;DEHYDRATASE, SHIKIMATE PATHWAY, LYASE, AROMATIC AMINO ACID BIOSYNTHESIS, tuberculosis, drug target, 3-dehydroshikimate, Structural Genomics, TB Structural Genomics Consortium, TBSGC ;; LYASE
实验方法 methodX-RAY DIFFRACTION

3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

3n59__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

3n59__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

3n59__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)35.72 Å
Rg(电子密度)35.01 Å
总 Rg35.65 Å
原子数12356
残基数1648
排除体积218990 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 3n59__assembly_1__model_1 dodecameric (12) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 3n59__assembly_2__model_1 dodecameric (12) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合物信息 Entities & Polymers (4)

6. 折叠分类 (SCOP + CATH) 49 domains

SCOP 2.08 (25 domains)

结构域编号 domain_idd3n59a_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59b_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59c_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59d_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59e_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59f_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59g_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59h_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59i_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59j_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59k_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59l_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59m1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59m2
类 Class classl — Artifacts
折叠类型 Fold foldl.1 — Tags
超家族 Superfamily superfamilyl.1.1 — Tags
家族 Family familyl.1.1.1 — Tags
结构域编号 domain_idd3n59n_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59o_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59p_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59q_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59r_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59s_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59t_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59u_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59v_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59w_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
结构域编号 domain_idd3n59x_
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.23 — Flavodoxin-like
超家族 Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
家族 Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase

CATH v4.4 (24 domains)

结构域编号 domain_id3n59A00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59B00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59C00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59D00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59E00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59F00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59G00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59H00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59I00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59J00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59K00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59L00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59M00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59N00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59O00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59P00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59Q00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59R00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59S00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59T00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59U00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59V00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59W00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II
结构域编号 domain_id3n59X00
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily9100 — Dehydroquinase, class II

7. 引用文献 (1)