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3qs4

Crystal structure of LeuT mutant F259V bound to sodium and L-tryptophan

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Na(+):neurotransmitter symporter (Snf family)

Aquifex aeolicus

UniProt O67854

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 TRYPTOPHAN × 3 octyl beta-D-glucopyranoside × 3 SODIUM ION × 2 water × 1 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 TRYPTOPHAN × 6 octyl beta-D-glucopyranoside × 6 SODIUM ION × 4 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2a65 2q6h 2q72 2qb4 2qei 2qju 3f3a 3f3c 3f3d 3f3e 3f48 3f4i

77 assemblies; showing the first 12

Homodimer
2a65 2q72 2qb4 2qei 3f3a 3f3c 3f3d 3f3e 3f48 3f4i 3f4j 3gjc

45 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3tt1 3tt1 3tt3

3 assemblies

View Construct and Data Evidence
UniProt name O67854_AQUAE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–513； UniProt 1–513

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3qs4
Deposition date deposition_date2011-02-19
Structure title titleCrystal structure of LeuT mutant F259V bound to sodium and L-tryptophan
Keywords keywords;NSS, neurotransmitter transporter, LeuT-fold, sodium-coupled secondary transporter, sodium and amino acid binding, membrane, TRANSPORT PROTEIN ;; TRANSPORT PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3qs4__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3qs4__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3qs4__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.47 Å
Rg (electron density)32.77 Å
Total Rg33.38 Å
Atom count8206
Residues1008
Excluded volume151170 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3qs4__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3qs4__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 1 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd3qs4a_
Class classf — Membrane and cell surface proteins and peptides
Fold Fold foldf.54 — SNF-like
Superfamily Superfamily superfamilyf.54.1 — SNF-like
Family Family familyf.54.1.1 — SNF-like
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7. Citations (1)