Lactotransferrin
OrganismNot specified
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Other combination Homooligomer Protein × 2 其他Polymer 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 361–695 Chain B； UniProt 700–705 | Fragment：C-lobe, UNP residues 361-695 Fragment：UNP residues 700-705 | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NPU (1R,2R)-2-amino-1-phenylpropan-1-ol × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K | Resolution 1.97 Å R-free 0.198 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 3U8Q | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1BLF STRUCTURE OF DIFERRIC BOVINE LACTOFERRIN AT 2.8 ANGSTROMS RESOLUTION Deposited 1997-08-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
20–708（689 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
dialaysis；pH 7.7；277 K；25 MM TRIS/HCL, PH 7.7 8% (V/V) MPD 6.5% (V/V) ETHANOL DIALYSED AGAINST A 200 MG/ML SOLUTION OF PROTEIN AT 277 K., dialaysis
|
Resolution 2.80 Å R-free 0.280 |
| 1LFC BOVINE LACTOFERRICIN (LFCINB), NMR, 20 STRUCTURES Deposited 1998-06-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
36–60（25 aa）
Fragment：RESIDUES 17 - 41 OF INTACT LACTOFERRIN
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K；Pressure 1
NMR sample composition
WATER
|
Resolution not provided |
| 1NKX CRYSTAL STRUCTURE OF A PROTEOLYTICALLY GENERATED FUNCTIONAL MONOFERRIC C-LOBE OF BOVINE LACTOFERRIN AT 1.9A RESOLUTION Deposited 2003-01-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–708（348 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550 AND 0.01 M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 1.90 Å R-free 0.222 |
| 1SDX Crystal structure of the zinc saturated C-terminal half of bovine lactoferrin at 2.0 A resolution reveals two additional zinc binding sites Deposited 2004-02-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe
Chain E
700–704（5 aa）
Fragment：residues 681-685
|
Mutation：N224K, K267E | ZN ZINC ION × 3 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；0.1M MES, 25% polyethylene glycol monomethylether 550, 0.01M zinc sulphate heptahydrate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.06 Å R-free 0.210 |
| 2ALU Detection of new binding site in the C-terminal lobe of lactoferrin:Crystal structure of the complex formed between bovine lactoferrin and a tetrasaccharide at 2.1A resolution Deposited 2005-08-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–708（348 aa）
Fragment：C-lobe
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOLMONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.09 Å R-free 0.212 |
| 2AYS A conserved non-metallic binding site in the C-terminal lobe of lactoferrin: Structure of the complex of C-terminal lobe of bovine lactoferrin with N-acetyl galactosamine at 1.86 A resolution Deposited 2005-09-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–708（348 aa）
Fragment：Lactoferrin lobe
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 A2G 2-acetamido-2-deoxy-alpha-D-galactopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.86 Å R-free 0.209 |
| 2B65 Crystal structure of the complex of C-lobe of bovine lactoferrin with maltose at 1.5A resolution Deposited 2005-09-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Not recorded | CO3 CARBONATE ION × 1 FE FE (III) ION × 1 ZN ZINC ION × 3 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 1.50 Å R-free 0.219 |
| 2DOJ Crystal structure of the complex of C-terminal lobe of bovine lactoferrin with adenosine at 2.4 A resolution Deposited 2006-04-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe (RESIDUES 342-686)
|
Not recorded | SO4 SULFATE ION × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ADN ADENOSINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG, MONOMETHYLETHER, 0.1M ZNSO4 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.40 Å R-free 0.223 |
| 2DP8 Carbohydrate recognition by lactoferrin: Crystal structure of the complex of C-terminal lobe of bovine lactoferrin with trisaccharide at 2.5 A resolution Deposited 2006-05-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C lobe(residues 342-686)
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE, GLYCOLMONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.50 Å R-free 0.200 |
| 2DQV Structure of the C-terminal lobe of bovine lactoferrin in complex with galactose at 2.7 A resolution Deposited 2006-05-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe(residues 342-686)
|
Not recorded | GAL beta-D-galactopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE, GLYCOLMONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.70 Å R-free 0.217 |
| 2DS9 Structure of the complex of C-terminal lobe of bovine lactoferrin with mannose at 2.8 A resolution Deposited 2006-06-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe(residues 342-686)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 MAN alpha-D-mannopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；298 K；PEG 3350 monomethyl ether, ZnSO4, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.80 Å R-free 0.228 |
| 2DSF Structure of the complex of C-terminal lobe of bovine lactoferrin with xylose at 2.8A resolution Deposited 2006-06-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe(residues 342-686)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 LXC beta-L-xylopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；PEG 3350, HEPES, ZnSO4, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.80 Å R-free 0.231 |
| 2DVC Structure of the bovine lactoferrin C-lobe complex with sucrose at 3.0 A resolution Deposited 2006-07-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01 M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 3.00 Å R-free 0.218 |
| 2DWA Structure of the complex of lactoferrin C-terminal half with fucose at 2.07 A resolution Deposited 2006-08-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Not recorded | FUC alpha-L-fucopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.07 Å R-free 0.209 |
| 2DWH Crystal structure of N-acetylglucosamine complex of bovine lactoferrin C-lobe at 2.8 A resolution Deposited 2006-08-12 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Mutation：N565K, K608E | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.80 Å R-free 0.228 |
| 2DWI Crystal structure of the complex formed between C-terminal half of bovine lactoferrin and cellobiose at 2.2 A resolution Deposited 2006-08-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Mutation：N565K, K608E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.20 Å R-free 0.221 |
| 2DWJ Structure of the complex of C-terminal lobe of bovine lactoferrin with raffinose at 2.3 A resolution Deposited 2006-08-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe(residues 342-686)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG MONOMETHYLETHER, 0.1M ZNSO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.207 |
| 2DXR Crystal structure of the complex formed between C-terminal half of bovine lactoferrin and sorbitol at 2.85 A resolution Deposited 2006-08-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Mutation：N565K, K608E | SOR sorbitol × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.85 Å R-free 0.227 |
| 2DXY Structure of the complex of C-terminal lobe of bovine lactoferrin with trehalose at 2.0 A resolution Deposited 2006-09-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-terminal lobe(residues 342-686)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG MONOMETHYLETHER, 0.1M ZNSO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.03 Å R-free 0.211 |
| 2DYX Structure of the complex of lactoferrin C-lobe with melibiose at 2.0 A resolution Deposited 2006-09-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
322–360（39 aa）
Fragment：residues 342-686
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE , pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.00 Å R-free 0.201 |
| 2E0S Carbohydrate recognition of C-terminal half of lactoferrin: Crystal structure of the complex of C-lobe with rhamnose at 2.15 A resolution Deposited 2006-10-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Not recorded | RAM alpha-L-rhamnopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.15 Å R-free 0.203 |
| 2E1S Crystal structure of the complex of C-terminal half of bovine lactoferrin and arabinose at 2.7 A resolution Deposited 2006-10-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Not recorded | ARA alpha-L-arabinopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.70 Å R-free 0.233 |
| 2FA7 Crystal structure of the complex of bovine lactoferrin C-lobe with a pentasaccharide at 2.38 A resolution Deposited 2005-12-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe complex, residues 361-705
|
Mutation：N565K, K608E | SO4 SULFATE ION × 1 ZN ZINC ION × 3 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG MONOMETHYLETHER, 0.1M ZNSO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.236 |
| 2G93 Ligand recognition site in C-lobe of lactoferrin: Crystal structure of the complex of C-lobe of bovine lactoferrin with methyl alpha-D-mannopyranoside at 1.9 A resolution Deposited 2006-03-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe(residues 342-686)
|
Not recorded | MMA methyl alpha-D-mannopyranoside × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, PEG monomethyl ether 550, 0.1M ZnSO4, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 1.90 Å R-free 0.229 |
| 2H4I Crystal structure of the complex of proteolytically produced C-terminal half of bovine lactoferrin with lactose at 2.55 A resolution Deposited 2006-05-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE , pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.55 Å R-free 0.216 |
| 2HCA Crystal structure of bovine lactoferrin C-lobe liganded with Glucose at 2.8 A resolution Deposited 2006-06-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：Peptidase S60 2 domain
|
Not recorded | GLC alpha-D-glucopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550 AND 0.01 M ZINC SULPHATE , pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.80 Å R-free 0.248 |
| 2MD1 Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide:biophysical aspects Deposited 2013-08-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
287–303（17 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K；Pressure ambient
NMR sample composition
55.5 M H2O-1, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2MD2 Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects Deposited 2013-08-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
287–296（10 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K；Pressure ambient
NMR sample composition
55.5 mM H2O-1, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2MD3 Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide:biophysical aspects Deposited 2013-08-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
296–303（8 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K；Pressure ambient
NMR sample composition
55.5 M H2O-1, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2MD4 Fragment based approach and binding behavior of LFampinB with Lipopolysaccharide: biophysical aspects Deposited 2013-08-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
287–298（12 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4.5；298 K；Pressure ambient
NMR sample composition
55.5 M H2O-1, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NUV Crystal structure of the complex of C-terminal lobe of bovine lactoferrin with atenolol at 2.25 A resolution Deposited 2006-11-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2TN 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；298 K；Hepes, ZnSO4, PEG monomethyl ether 550, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.25 Å R-free 0.235 |
| 2NWJ Structure of the complex of C-terminal lobe of bovine lactoferrin with disaccharide at 1.75 A resolution Deposited 2006-11-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：residues 342-686 (361-705)
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；298 K；HEPES, PEG 550 Monomethyl ether, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.25 Å R-free 0.227 |
| 2O1L Structure of a complex of C-terminal lobe of bovine lactoferrin with disaccharide at 1.97 A resolution Deposited 2006-11-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-terminal lobe (residues 361-705)
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；298 K；HEPES, PEG 550 monomethyl ether, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.97 Å R-free 0.231 |
| 2O51 Crystal structure of bovine C-lobe with fructose at 3.0 A resolution Deposited 2006-12-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe(residues 342-686)
|
Not recorded | FRU beta-D-fructofuranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG MONOMETHYL ETHER 550, 0.1M ZNSO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.00 Å R-free 0.202 |
| 2OCU Structure of the complex of C-terminal lobe of bovine lactoferrin with N-(4-hydroxyphenyl) acetamide at 2.38 A resolution Deposited 2006-12-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-terminal lobe(RESIDUES 342-686)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 TYL N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL) × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；HEPES, PEG Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.223 |
| 2P1S Crystal structure of the C-terminal lobe of bovine lactoferrin complexed with O-alpha-D-Glucopyranosyl-(1 3)-alpha-D-fructofuranosyl- (2 1)- alpha-D-glucopyranoside at 1.93 A resolution Deposited 2007-03-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–704（344 aa）
Fragment：c-terminal lobe(residues 342-685)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；298 K；0.1M HEPES, 0.2M ZnSO4, 20% PEG monomethyl ether, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.93 Å R-free 0.217 |
| 2PX1 crystal structure of the complex of bovine lactoferrin C-lobe with Ribose at 2.5 A resolution Deposited 2007-05-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：Residues 361-705
|
Not recorded | RIP beta-D-ribopyranose × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M znso4, 25% PEG, Monomethyl ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 2.50 Å R-free 0.228 |
| 2Q8J Crystal Structure of the complex of C-lobe of bovine lactoferrin with Mannitol and Mannose at 2.7 A resolution Deposited 2007-06-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–708（348 aa）
Fragment：C-lobe
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 BMA beta-D-mannopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 M2P D-MANNITOL-1,6-DIPHOSPHATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG MONOMETHYLETHER, 0.1M ZNSO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.71 Å R-free 0.240 |
| 2QJE Crystal structure of the complex of Bovine C-lobe with Amygdalin at 2.3A resolution Deposited 2007-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–708（348 aa）
Fragment：UNP residues 361-708
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 SO4 SULFATE ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG MONOMETHYLETHER, 0.1M ZNSO4, VAPOR DIFFUSION, HANGING DROP, pH 6.5, temperature 298.0K
|
Resolution 2.30 Å R-free 0.227 |
| 2R71 Crystal structure of the complex of bovine C-lobe with inositol at 2.1A resolution Deposited 2007-09-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 2 INS 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, 25% POLYETHYLENE GLYCOL MONOMETHYL ETHER 550, 0.01M ZINC SULPHATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.07 Å R-free 0.229 |
| 2R9J Ligand recognition in C-lobe: The crystal structure of the complex of lactoferrin C-lobe with nicotinamide at 2.5 A resolution Deposited 2007-09-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NCA NICOTINAMIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M ZnSO4, 0.1M MES, 25% PEG, Monomethyl ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.55 Å R-free 0.249 |
| 2ZMB Crystal structure of the complex of C-terminal lobe of bovine lactoferrin with parecoxib at 2.9 A resolution Deposited 2008-04-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：c-lobe
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 PXB parecoxib × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, PEG, MONOMETHYLETHER, 0.1M ZNSO4, VAPOR DIFFUSION, HANGING DROP, pH 6.5, temperature 298K
|
Resolution 2.90 Å R-free 0.222 |
| 3CFL Crystal structure of the complex formed between C-lobe of bovine lactoferrin and 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine at 2.25 A resolution Deposited 2008-03-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 5CH 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M ZnSO4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.25 Å R-free 0.225 |
| 3CI8 Crystal structure of the complex of C-lobe of lactoferrin with vitamin B3 (niacin) at 2.4 A resolution Deposited 2008-03-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：Peptidase S60 2, UNP residues 361-705
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 NIO NICOTINIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.40 Å R-free 0.200 |
| 3CRB Crystal structure of the complex of C-lobe of lactoferrin with 2-chromenone at 2.6 A resolution Deposited 2008-04-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 COU COUMARIN × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；01M ZNSO4, 0.1M MES, 25% PEG, MONOETHYL ETHER 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.60 Å R-free 0.211 |
| 3E9X Crystal Structure of the Complex of C-lobe of Lactoferrin with Nimesulide at 2.7 A Resolution Deposited 2008-08-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe
|
Not recorded | NIM 4-NITRO-2-PHENOXYMETHANESULFONANILIDE × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M ZNSO4, 0.1M MES, 25% PEG, MONOETHYL ETHER 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.70 Å R-free 0.235 |
| 3IAZ Structural basis of the prevention of NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe) of bovine colostrum protein lactoferrin: Binding and structural studies of the C-lobe complex with aspirin Deposited 2009-07-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：UNP residues 361-705
|
Not recorded | AIN 2-(ACETYLOXY)BENZOIC ACID × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 EOH ETHANOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；25% PEG MONOMETHYL ETHER-550, 0.1M ZNSO4, 0.1M MES, PH6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
|
Resolution 2.00 Å R-free 0.228 |
| 3IB0 Structural basis of the prevention of NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe) of bovine colostrum protein lactoferrin: Binding and structural studies of C-lobe complex with diclofenac Deposited 2009-07-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：UNP residues 361-705
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 DIF 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID × 1 SO4 SULFATE ION × 2 ZN ZINC ION × 2 EOH ETHANOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1M MES, 25% POLY ETHYLENE GLYCOL MONOMETHYL ETHER-550, 0.1M ZNSO4, PH6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
|
Resolution 1.40 Å R-free 0.219 |
| 3IB1 Structural basis of the prevention of NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe) of bovine colostrum protein lactoferrin: Binding and structural studies of C-lobe complex with indomethacin Deposited 2009-07-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：UNP residues 361-705
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 IMN INDOMETHACIN × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；25% PEG MONOMETHYL ETHER-550, 0.1M MES, 0.01M ZNSO4, PH6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
|
Resolution 2.20 Å R-free 0.244 |
| 3IB2 structure of the complex of C-terminal half (C-lobe) of bovine lactoferrin with alpha-methyl-4-(2-methylpropyl) benzene acetic acid Deposited 2009-07-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：UNP residues 361-705
|
Mutation：N565K, K608E | IBP IBUPROFEN × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M ZNSO4, 0.1M MES, 25% PEG, MONOMETHYL ETHER 550, PH6.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
|
Resolution 2.29 Å R-free 0.220 |
| 3K0V Removal of sugars and sugars-like molecules from the solution by C-lobe of lactoferrin: Crystal structure of the complex of C-lobe with beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-alpha-D-glucopyranose at 1.9 A resolution Deposited 2009-09-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
|
Not recorded | SO4 SULFATE ION × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.91 Å R-free 0.237 |
| 3KJ7 Crystal Structure of the Complex of C-lobe of Bovine Lactoferrin with Dextrin at 1.9 A Resolution Deposited 2009-11-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
|
Not recorded | SO4 SULFATE ION × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.91 Å R-free 0.241 |
| 3MJN Crystal Structure of the complex of C-lobe of lactoferrin with isopropylamino-3-(1-naphthyloxy)propan-2-ol at 2.38 A Resolution Deposited 2010-04-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe (UNP RESIDUES 361-705)
|
Mutation：N565K, K608E | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 SO4 SULFATE ION × 1 RNP (1E,2R)-1-(ISOPROPYLIMINO)-3-(1-NAPHTHYLOXY)PROPAN-2-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.38 Å R-free 0.211 |
| 3O97 Crystal Structure of the complex of C-lobe of lactoferrin with indole acetic acid at 2.68 A Resolution Deposited 2010-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe (UNP RESIDUES 361-705)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 IAC 1H-INDOL-3-YLACETIC ACID × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, temperature 298K
|
Resolution 2.68 Å R-free 0.222 |
| 3RGY Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Lipopolysaccharide at 2.0 A Resolution Deposited 2011-04-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 LP5 (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.00 Å R-free 0.221 |
| 3SDF Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Lipoteichoic acid at 2.1 A Resolution Deposited 2011-06-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：UNP RESIDUES 361-705
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 LTC (2S)-1-({3-O-[2-(acetylamino)-4-amino-2,4,6-trideoxy-beta-D-galactopyranosyl]-alpha-D-glucopyranosyl}oxy)-3-(heptanoyloxy)propan-2-yl (7Z)-pentadec-7-enoate × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.234 |
| 3TAJ Crystal structure of C-lobe of bovine lactoferrin complexed with Nabumetone at 1.7A resolution Deposited 2011-08-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe (UNP RESIDUES 361-705)
|
Not recorded | NBO nabumetone × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.70 Å R-free 0.223 |
| 3TOD Crystal Structure of C-lobe of Bovine lactoferrin Complexed with 1-Butyl-1H-Pyrazole-5-carboxylic acid at 1.38 A Resolution Deposited 2011-09-05 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-705
Chain B
700–705（6 aa）
|
Not recorded | FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 GOL GLYCEROL × 2 EOH ETHANOL × 2 XXB 1-butyl-1H-pyrazole-5-carboxylic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.38 Å R-free 0.236 |
| 3TTR Crystal structure of C-lobe of bovine lactoferrin complexed with Lidocaine at 2.27 A resolution Deposited 2011-09-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe (UNP RESIDUES 361-705)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 LQZ 2-(diethylamino)-N-(2,6-dimethylphenyl)ethanamide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.27 Å R-free 0.241 |
| 3TUS Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Meta-hydroxy benzoic acid at 2.5 A Resolution Deposited 2011-09-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe (UNP RESIDUES 361-705)
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 3HB 3-HYDROXYBENZOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.50 Å R-free 0.241 |
| 3U72 Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Isoniazid at 2.2 A Resolution Deposited 2011-10-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：UNP residues 361-695
Chain B
700–705（6 aa）
Fragment：UNP residues 700-705
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 ISZ 4-(DIAZENYLCARBONYL)PYRIDINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.230 |
| 3UGW Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Deoxycytidine at 1.87 A Resolution Deposited 2011-11-03 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 GOL GLYCEROL × 1 DCZ 2'-DEOXYCYTIDINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.87 Å R-free 0.223 |
| 3UK4 Crystal Structure of C-lobe of Bovine lactoferrin Complexed with 1,2,5-Pentanetriol at 1.98 A Resolution Deposited 2011-11-09 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 XXD (2S)-pentane-1,2,5-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.98 Å R-free 0.241 |
| 3USD Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Imidazol (1,2 a) pyridine3-yl-acitic acid at 2.4 A Resolution Deposited 2011-11-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 IDL imidazo[1,2-a]pyridin-3-ylacetic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.40 Å R-free 0.260 |
| 3V5A Crystal Structure of C-lobe of Bovine Lactoferrin Complexed with Gamma Amino Butyric Acid at 1.44 A Resolution Deposited 2011-12-16 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 GOL GLYCEROL × 1 ABU GAMMA-AMINO-BUTANOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.44 Å R-free 0.191 |
| 3VDF Crystal Structure of C-lobe of Bovine lactoferrin Complexed with diaminopimelic acid at 1.46 A Resolution Deposited 2012-01-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 API 2,6-DIAMINOPIMELIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.46 Å R-free 0.194 |
| 4DIG Crystal Structure of C-lobe of Bovine lactoferrin Complexed with N-acetylmuramyl l-alanyl d-isoglutamine at 1.8 A Resolution Deposited 2012-01-31 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 DGN D-GLUTAMINE × 1 ALA ALANINE × 1 LAC LACTIC ACID × 1 NDG 2-acetamido-2-deoxy-alpha-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.216 |
| 4DXU Crystal Structure of C-lobe of Bovine lactoferrin Complexed with aminocaproic acid at 1.46 A Resolution Deposited 2012-02-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 ACA 6-AMINOHEXANOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M ZnSO4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.46 Å R-free 0.187 |
| 4FIM Crystal Structure of C-lobe of Bovine lactoferrin Complexed with celecoxib acid at 1.80 A Resolution Deposited 2012-06-09 | Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 ZN ZINC ION × 2 CEL 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.211 |
| 4FJP Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Naproxen at 1.68 A Resolution Deposited 2012-06-12 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NPS (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.68 Å R-free 0.208 |
| 4FOR Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Flurbiprofen at 1.58 A Resolution Deposited 2012-06-21 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FLP FLURBIPROFEN × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.58 Å R-free 0.205 |
| 4G2Z Crystal Structure of C-lobe of Bovine lactoferrin Complexed with Mefenamic acid at 1.90 A Resolution Deposited 2012-07-13 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 FE FE (III) ION × 1 ZN ZINC ION × 2 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 ID8 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.191 |
| 4G77 Crystal Structure of C-lobe of Bovine lactoferrin Complexed with tolfenamic acid at 1.98 A Resolution Deposited 2012-07-20 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe, UNP RESIDUES 361-705
|
Not recorded | FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 TLF 2-[(3-chloro-2-methylphenyl)amino]benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.98 Å R-free 0.211 |
| 4G8H Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 A resolution Deposited 2012-07-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
Fragment：C-lobe, UNP RESIDUES 361-705
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 LCF [6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.88 Å R-free 0.212 |
| 4GRK Crystal Structure of C-lobe of Bovine lactoferrin Complexed with ketorolac at 1.68 A Resolution Deposited 2012-08-25 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：C-lobe, UNP RESIDUES 361-695
Chain B
700–705（6 aa）
Fragment：C-lobe, UNP RESIDUES 700-705
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 GOL GLYCEROL × 2 KTR (1R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M Znso4, 0.1M MES, 25% PEG, Monomethyl Ether 550 , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.68 Å R-free 0.205 |
| 4N6P Crystal Structure of C-lobe of Bovine lactoferrin complexed with meclofenamic acid at 1.4 A resolution Deposited 2013-10-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–695（335 aa）
Fragment：UNP residues 361-695
Chain B
700–705（6 aa）
|
Not recorded | ZN ZINC ION × 1 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 GOL GLYCEROL × 2 JMS 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.01M ZnSO4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.208 |
| 4NED Crystal STRUCTURE OF C-LOBE OF BOVINE LACTOFERRIN COMPLEXED WITH FENOPROFEN AT 2.1 ANGSTROM RESOLUTION Deposited 2013-10-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–705（345 aa）
|
Not recorded | ZN ZINC ION × 2 FE FE (III) ION × 1 CO3 CARBONATE ION × 1 SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 PFN FENOPROFEN × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；298 K；0.01M ZnSO4, 0.1M MES, 25% PEG, Monomethyl Ether 550, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.252 |
| 4OQO Crystal structure of the tryptic generated iron-free C-lobe of bovine Lactoferrin at 2.42 Angstrom resolution Deposited 2014-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–708（348 aa）
Fragment：C-lobe, UNP RESIDUES 361-708
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；8% Tacsimate, 20% PEG 3350, pH 4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.42 Å R-free 0.260 |
| 4OQO Crystal structure of the tryptic generated iron-free C-lobe of bovine Lactoferrin at 2.42 Angstrom resolution Deposited 2014-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
361–708（348 aa）
Fragment：C-lobe, UNP RESIDUES 361-708
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；8% Tacsimate, 20% PEG 3350, pH 4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.42 Å R-free 0.260 |
| 5CRY Structure of iron-saturated C-lobe of bovine lactoferrin at pH 6.8 indicates the softening of iron coordination Deposited 2015-07-23 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–708（348 aa）
Fragment：C-LOBE (UNP RESIDUES 361-708)
Chain B
361–708（348 aa）
Fragment：C-LOBE (UNP RESIDUES 361-708)
|
Not recorded | FE FE (III) ION × 2 BCT BICARBONATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；300 K；0.05M HEPES, 20% PEG 20K
|
Resolution 2.79 Å R-free 0.273 |
| 5HBC Intermediate structure of iron-saturated C-lobe of bovine lactoferrin at 2.79 Angstrom resolution indicates the softening of iron coordination Deposited 2015-12-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
361–708（348 aa）
Fragment：UNP residues 361-708
|
Not recorded | FE FE (III) ION × 1 BCT BICARBONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；300 K；0.05M HEPES, 20% PEG 20000
|
Resolution 2.79 Å R-free 0.273 |
| 5HBC Intermediate structure of iron-saturated C-lobe of bovine lactoferrin at 2.79 Angstrom resolution indicates the softening of iron coordination Deposited 2015-12-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
361–708（348 aa）
Fragment：UNP residues 361-708
|
Not recorded | FE FE (III) ION × 1 BCT BICARBONATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；300 K；0.05M HEPES, 20% PEG 20000
|
Resolution 2.79 Å R-free 0.273 |
| 7ENU Crystal structure of iron-saturated C-terminal half of lactoferrin produced proteolytically using pepsin at 2.32A resolution Deposited 2021-04-19 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–708（348 aa）
Chain B
361–708（348 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Magnesium acetate, 20% PEG 3350
|
Resolution 2.32 Å R-free 0.249 |
| 7EQU Crystal structure of the C-lobe of lactoferrin produced by limited proteolysis using pepsin at 2.74A resolution Deposited 2021-05-04 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–708（348 aa）
Fragment：UNP residues 361-708
Chain B
361–708（348 aa）
Fragment：UNP residues 361-708
|
Not recorded | FE FE (III) ION × 2 BCT BICARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Magnesium acetate, 20% PEG 3350
|
Resolution 2.74 Å R-free 0.298 |
| 7EV0 Crystal structure of pepsin cleaved C-terminal half of lactoferrin at 2.7A resolution Deposited 2021-05-19 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–708（348 aa）
Chain P
361–708（348 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Magnesium acetate, 20% PEG 3350
|
Resolution 2.70 Å R-free 0.314 |
| 7EVQ Crystal structure of C-terminal half of lactoferrin obtained by limited proteolysis using pepsin at 2.6 A resolution Deposited 2021-05-21 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–708（348 aa）
Chain B
361–708（348 aa）
|
Not recorded | FE FE (III) ION × 2 BCT BICARBONATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 EDO 1,2-ETHANEDIOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Magnesium Acetate 20%, PEG 3350.
|
Resolution 2.60 Å R-free 0.284 |
| 7FDW Crystal structure of pepsin cleaved lactoferrin C-lobe at 2.28 A resolution Deposited 2021-07-18 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
361–708（348 aa）
Chain B
361–708（348 aa）
|
Not recorded | FE FE (III) ION × 2 CO3 CARBONATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；Magnesium acetate, 20% PEG 3350
|
Resolution 2.28 Å R-free 0.247 |
| 9XXU Crystal structure of the chymotrypsin-cleaved iron-free C-lobe of bovine lactoferrin at 2.82 Angstrom resolution Deposited 2025-12-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
362–699（338 aa）
Chain C
700–708（9 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 GOL GLYCEROL × 1 ACT ACETATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1M Sodium acetate trihydrate (pH 4.6), 0.2M ammonium sulfate, 25% w/v PEG 2000
|
Resolution 2.82 Å R-free 0.269 |
| 9XXU Crystal structure of the chymotrypsin-cleaved iron-free C-lobe of bovine lactoferrin at 2.82 Angstrom resolution Deposited 2025-12-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
362–699（338 aa）
Chain D
700–708（9 aa）
|
Not recorded | GOL GLYCEROL × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1M Sodium acetate trihydrate (pH 4.6), 0.2M ammonium sulfate, 25% w/v PEG 2000
|
Resolution 2.82 Å R-free 0.269 |
86 other PDB entries and 89 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | TRFL_BOVIN |
| Isoform | — |
| PDB entities | 1, 2 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–335； UniProt 361–695 Author chain B； PDBConstruct 1–6； UniProt 700–705 |
