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4bpm

Crystal structure of a human integral membrane enzyme

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROSTAGLANDIN E SYNTHASE, FUSION PEPTIDE

SYNTHETIC CONSTRUCT

UniProt O14684

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 GLUTATHIONE × 3 ;2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide ; × 3 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
3dww 4al0 4al1 4bpm 4yk5 4yl0 4yl1 4yl3 5bqg 5bqh 5bqi 5k0i

17 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
4wab

1 assemblies

View Construct and Data Evidence
UniProt name PTGES_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 8–150； UniProt 10–152

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4bpm
Deposition date deposition_date2013-05-27
Structure title titleCrystal structure of a human integral membrane enzyme
Keywords keywords;ISOMERASE, CANCER, DRUG TARGET, IN MESO CRYSTALLIZATION, INFLAMMATION, INHIBITOR, LEUKOTRIENE C4 SYNTHASE, LIPID METABOLISM, MEMBRANE-ASSOCIATED PROTEINS IN EICOSANOID AND GLUTATHIONE METABOLISM, MAPAG, MEMBRANE PROTEIN, MPGES1, PAIN, MICROCRYSTAL, ANOMALOUS DISPERSION, SULFUR-SAD, S-SAD ;; ISOMERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4bpm__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4bpm__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4bpm__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.84 Å
Rg (electron density)25.29 Å
Total Rg26.00 Å
Atom count4059
Residues486
Excluded volume73653 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4bpm__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id4bpmA00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily550 — Membrane associated eicosanoid/glutathione metabolism-like domain
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7. Citations (1)