4c3e

HRSV M2-1 mutant S58D S61D, P21 crystal

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

MATRIX M2-1

HUMAN RESPIRATORY SYNCYTIAL VIRUS

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 4	ZINC ION × 4 water × 4	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 4	ZINC ION × 4 water × 4	Consistent with protein count
3	Protein homooligomer	Homooligomer	Protein 4	ZINC ION × 4 water × 4	Consistent with protein count
4	Protein homooligomer	Homooligomer	Protein 4	ZINC ION × 4 water × 4	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	M21_HRSVA
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 6–199； UniProt 1–194 Author chain B； PDBConstruct 6–199； UniProt 1–194 Author chain C； PDBConstruct 6–199； UniProt 1–194 Author chain D； PDBConstruct 6–199； UniProt 1–194 Author chain E； PDBConstruct 6–199； UniProt 1–194 Author chain F； PDBConstruct 6–199； UniProt 1–194 Author chain G； PDBConstruct 6–199； UniProt 1–194 Author chain H； PDBConstruct 6–199； UniProt 1–194 Author chain I； PDBConstruct 6–199； UniProt 1–194 Author chain J； PDBConstruct 6–199； UniProt 1–194 Author chain K； PDBConstruct 6–199； UniProt 1–194 Author chain L； PDBConstruct 6–199； UniProt 1–194 Author chain M； PDBConstruct 6–199； UniProt 1–194 Author chain N； PDBConstruct 6–199； UniProt 1–194 Author chain O； PDBConstruct 6–199； UniProt 1–194 Author chain P； PDBConstruct 6–199； UniProt 1–194

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4c3e
Deposition date deposition_date	2013-08-22
Structure title title	HRSV M2-1 mutant S58D S61D, P21 crystal
Keywords keywords	VIRAL PROTEIN; VIRAL PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4c3e__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4c3e__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4c3e__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	27.71 Å
Rg (electron density)	26.82 Å
Total Rg	27.69 Å
Atom count	5319
Residues	658
Excluded volume	95049 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4c3e__assembly_1__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`4c3e__assembly_2__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
3	1	`4c3e__assembly_3__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download
4	1	`4c3e__assembly_4__model_1`	tetrameric （4）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Description description	MATRIX M2-1
Molecular weight formula_weight	22657.8 kDa
Mutation mutation	YES
Source method src_method	man
Copy count entity_count	16

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P
Atom count atom_count	21997

GPLGSMSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLDEIDGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT

Source Source

Source organism organism	HUMAN RESPIRATORY SYNCYTIAL VIRUS
NCBI taxonomy ID ncbi_taxonomy_id	11259
Host organism host_organism	ESCHERICHIA COLI

Entity 2 Entity 2 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	16

Entity 3 Entity 3 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	395

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6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

Domain ID domain_id	4c3eA00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eB00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eC00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eD00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eE00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eF00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eG00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eH00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eI00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eJ00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eK00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eL00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eM00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eN00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eO00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

Domain ID domain_id	4c3eP00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily	1350 — Pneumovirus matrix protein 2 (M2), zinc-binding domain

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Unit-cell length a length_a	89.680 Å
Unit-cell length b length_b	141.600 Å
Unit-cell length c length_c	142.160 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	93.92 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	32

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	2.400 Å
Low-resolution limit resolution_low	78.240 Å
R factor r_factor	0.2051
R_work r_work	0.2035
R_free r_free	0.2377

HRSV M2-1 mutant S58D S61D, P21 crystal

1. Protein Identity and Related Structures Protein Identity & Related Structures

MATRIX M2-1

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4c3e__assembly_1__model_1

4c3e__assembly_1__model_1 | I(q)

4c3e__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 water

6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

7. Citations (1)

HRSV M2-1 mutant S58D S61D, P21 crystal

1. Protein Identity and Related Structures Protein Identity & Related Structures

MATRIX M2-1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4c3e__assembly_1__model_1

4c3e__assembly_1__model_1 | I(q)

4c3e__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (3)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 water

6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

7. Citations (1)