← Back to search
4ckw

Structure of the Mycobacterium tuberculosis Type II Dehydroquinase N12S mutant (Crystal Form 1)

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

3-DEHYDROQUINATE DEHYDRATASE

MYCOBACTERIUM TUBERCULOSIS

UniProt P0A4Z6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 GLYCEROL × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count
4 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4ckw 4ckw 4ckw 4ckw

4 assemblies

Homodimer
4ckz

1 assemblies

Homotetramer

None

Other homooligomers
1h0s 2dhq 2dhq 2xb8 2y71 2y76 2y77 3n59 3n59 3n76 3n7a 3n7a

38 assemblies; showing the first 12

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name AROQ_MYCTU
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–146； UniProt 2–147 Author chain B； PDBConstruct 1–146； UniProt 2–147 Author chain C； PDBConstruct 1–146； UniProt 2–147 Author chain D； PDBConstruct 1–146； UniProt 2–147

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id4ckw
Deposition date deposition_date2014-01-10
Structure title titleStructure of the Mycobacterium tuberculosis Type II Dehydroquinase N12S mutant (Crystal Form 1)
Keywords keywords;BACTERIAL PROTEINS, BINDING SITES, CRYSTALLIZATION, MODELS, MOLECULAR, MYCOBACTERIUM TUBERCULOSIS, TYPE 2 DEHYDROQUINASE, LYASE, INHIBITOR, PROTEIN BINDING, PROTEIN STRUCTURE, SHIKIMIS ACID PATHWAY, SUBSTRATE SPECIFICITY ;; LYASE
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4ckw__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4ckw__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4ckw__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.69 Å
Rg (electron density)13.14 Å
Total Rg14.52 Å
Atom count855
Residues115
Excluded volume15323 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4ckw__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4ckw__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4ckw__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4ckw__assembly_4__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (4)

▼

6. Fold Classification (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd4ckwa_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.23 — Flavodoxin-like
Superfamily Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
Family Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
Domain ID domain_idd4ckwb_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.23 — Flavodoxin-like
Superfamily Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
Family Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
Domain ID domain_idd4ckwc_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.23 — Flavodoxin-like
Superfamily Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
Family Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase
Domain ID domain_idd4ckwd_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.23 — Flavodoxin-like
Superfamily Superfamily superfamilyc.23.13 — Type II 3-dehydroquinate dehydratase
Family Family familyc.23.13.1 — Type II 3-dehydroquinate dehydratase

CATH v4.4 (4 domains)

Domain ID domain_id4ckwA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily9100 — Dehydroquinase, class II
Domain ID domain_id4ckwB00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily9100 — Dehydroquinase, class II
Domain ID domain_id4ckwC00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily9100 — Dehydroquinase, class II
Domain ID domain_id4ckwD00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily9100 — Dehydroquinase, class II
▶

7. Citations (1)