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4djz

Catalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Mannan-binding lectin serine protease 1 heavy chain

Homo sapiens

UniProt P48740

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Protease inhibitor SGPI-2 × 1 （O46162） water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Protease inhibitor SGPI-2 × 1 （O46162） water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4igd 4kkd 4kkd

3 assemblies

Homodimer
3gov

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4aqb 4djz 4djz 4iw4 4iw4 7arx 7pqo 7pqo

8 assemblies

View Construct and Data Evidence
UniProt name MASP1_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 5–155； UniProt 298–448 Author chain C； PDBConstruct 5–155； UniProt 298–448 Author chain B； PDBConstruct 1–251； UniProt 449–699 Author chain D； PDBConstruct 1–251； UniProt 449–699

Protease inhibitor SGPI-2

Schistocerca gregaria

UniProt O46162

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Mannan-binding lectin serine protease 1 heavy chain × 1 （P48740） Mannan-binding lectin serine protease 1 light chain × 1 （P48740） water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Mannan-binding lectin serine protease 1 heavy chain × 1 （P48740） Mannan-binding lectin serine protease 1 light chain × 1 （P48740） water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1kgm 1kio 1kj0

3 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2f91 2xtt 3tvj 4djz 4djz

5 assemblies

View Construct and Data Evidence
UniProt name SGP1_SCHGR
Isoform —
PDB entities 3
Chains and sequence ranges Author chain H； PDBConstruct 4–38； UniProt 57–91 Author chain I； PDBConstruct 4–38； UniProt 57–91

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4djz
Deposition date deposition_date2012-02-03
Structure title titleCatalytic fragment of masp-1 in complex with its specific inhibitor developed by directed evolution on sgci scaffold
Keywords keywordsin vitro evolution, specific inhibitor, hydrolase, HYDROLASE-HYDROLASE INHIBITOR complex; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4djz__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4djz__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4djz__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）32.03 Å
Rg (electron density)33.11 Å
Total Rg33.05 Å
Atom count3198
Residues432
Excluded volume56355 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4djz__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4djz__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id4djzA01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id4djzA02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id4djzB01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id4djzB02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id4djzC01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id4djzC02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology70 — Complement Module; domain 1
Homologous superfamily homologous superfamily10 — Complement Module, domain 1
Domain ID domain_id4djzD01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id4djzD02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
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7. Citations (1)