Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein monomer | Monomer | Protein 1 | GLYCEROL × 2 water × 1 | Consistent with protein count |
| UniProt name | ALK_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–327； UniProt 1084–1410 |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
| Entry ID entry_id | 4fnw |
| Deposition date deposition_date | 2012-06-20 |
| Structure title title | Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain |
| Keywords keywords | receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, TRANSFERASE; TRANSFERASE |
| Experimental Method method | X-RAY DIFFRACTION |
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 21.27 Å |
| Rg (electron density) | 20.30 Å |
| Total Rg | 21.16 Å |
| Atom count | 2408 |
| Residues | 304 |
| Excluded volume | 43133 ų |
| Maximum q | 0.500 Å⁻¹ |
| Domain ID domain_id | d4fnwa_ |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.144 — Protein kinase-like (PK-like) |
| Superfamily Superfamily superfamily | d.144.1 — Protein kinase-like (PK-like) |
| Family Family family | d.144.1.0 — automated matches |
| Domain ID domain_id | 4fnwA01 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 200 — Phosphorylase Kinase; domain 1 |
| Homologous superfamily homologous superfamily | 20 — Phosphorylase Kinase; domain 1 |
| Domain ID domain_id | 4fnwA02 |
| Class class | 1 — Mainly Alpha |
| Architecture architecture | 10 — Orthogonal Bundle |
| Topology topology | 510 — Transferase(Phosphotransferase); domain 1 |
| Homologous superfamily homologous superfamily | 10 — Transferase(Phosphotransferase) domain 1 |