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4pc3

Elongation factor Tu:Ts complex with partially bound GDP

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Elongation factor Tu 1

Escherichia coli

UniProt P0CE47

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Elongation factor Ts × 1 （P0A6P1） GUANOSINE-5'-DIPHOSPHATE × 1 GLYCEROL × 2 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Elongation factor Ts × 1 （P0A6P1） GUANOSINE-5'-DIPHOSPHATE × 1 GLYCEROL × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5mi3 5mi3

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3u2q 3u6b 3u6b 3u6k 3u6k 4g5g 4p3y 4pc3 4pc3 4pc7 4q7j 4q7j

19 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name EFTU1_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–394； UniProt 1–394 Author chain B； PDBConstruct 1–394； UniProt 1–394

Elongation factor Ts

Escherichia coli

UniProt P0A6P1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Elongation factor Tu 1 × 1 （P0CE47） GUANOSINE-5'-DIPHOSPHATE × 1 GLYCEROL × 2 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Elongation factor Tu 1 × 1 （P0CE47） GUANOSINE-5'-DIPHOSPHATE × 1 GLYCEROL × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1efu 3mmp 3mmp 3mmp 4pc3 4pc3 4pc7 4q7j 4q7j 4r71 4r71

11 assemblies

View Construct and Data Evidence
UniProt name EFTS_ECOLI
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–282； UniProt 2–283 Author chain D； PDBConstruct 1–282； UniProt 2–283

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4pc3
Deposition date deposition_date2014-04-14
Structure title titleElongation factor Tu:Ts complex with partially bound GDP
Keywords keywordsG:GEF:GDP complex, Elongation factor, Translation, Protein synthesis; TRANSLATION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4pc3__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4pc3__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4pc3__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）30.61 Å
Rg (electron density)30.03 Å
Total Rg30.73 Å
Atom count9912
Residues642
Excluded volume88236 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4pc3__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4pc3__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 26 domains

SCOP 2.08 (12 domains)

Domain ID domain_idd4pc3a1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd4pc3a2
Class classb — All beta proteins
Fold Fold foldb.43 — Reductase/isomerase/elongation factor common domain
Superfamily Superfamily superfamilyb.43.3 — Translation proteins
Family Family familyb.43.3.0 — automated matches
Domain ID domain_idd4pc3a3
Class classb — All beta proteins
Fold Fold foldb.44 — Elongation factor/aminomethyltransferase common domain
Superfamily Superfamily superfamilyb.44.1 — EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
Family Family familyb.44.1.0 — automated matches
Domain ID domain_idd4pc3b1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd4pc3b2
Class classb — All beta proteins
Fold Fold foldb.43 — Reductase/isomerase/elongation factor common domain
Superfamily Superfamily superfamilyb.43.3 — Translation proteins
Family Family familyb.43.3.0 — automated matches
Domain ID domain_idd4pc3b3
Class classb — All beta proteins
Fold Fold foldb.44 — Elongation factor/aminomethyltransferase common domain
Superfamily Superfamily superfamilyb.44.1 — EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
Family Family familyb.44.1.0 — automated matches
Domain ID domain_idd4pc3c1
Class classa — All alpha proteins
Fold Fold folda.5 — RuvA C-terminal domain-like
Superfamily Superfamily superfamilya.5.2 — UBA-like
Family Family familya.5.2.2 — TS-N domain
Domain ID domain_idd4pc3c2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.43 — EF-Ts domain-like
Superfamily Superfamily superfamilyd.43.1 — Elongation factor Ts (EF-Ts), dimerisation domain
Family Family familyd.43.1.1 — Elongation factor Ts (EF-Ts), dimerisation domain
Domain ID domain_idd4pc3c3
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.43 — EF-Ts domain-like
Superfamily Superfamily superfamilyd.43.1 — Elongation factor Ts (EF-Ts), dimerisation domain
Family Family familyd.43.1.1 — Elongation factor Ts (EF-Ts), dimerisation domain
Domain ID domain_idd4pc3d1
Class classa — All alpha proteins
Fold Fold folda.5 — RuvA C-terminal domain-like
Superfamily Superfamily superfamilya.5.2 — UBA-like
Family Family familya.5.2.2 — TS-N domain
Domain ID domain_idd4pc3d2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.43 — EF-Ts domain-like
Superfamily Superfamily superfamilyd.43.1 — Elongation factor Ts (EF-Ts), dimerisation domain
Family Family familyd.43.1.1 — Elongation factor Ts (EF-Ts), dimerisation domain
Domain ID domain_idd4pc3d3
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.43 — EF-Ts domain-like
Superfamily Superfamily superfamilyd.43.1 — Elongation factor Ts (EF-Ts), dimerisation domain
Family Family familyd.43.1.1 — Elongation factor Ts (EF-Ts), dimerisation domain

CATH v4.4 (14 domains)

Domain ID domain_id4pc3A01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4pc3A02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id4pc3A03
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id4pc3B01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4pc3B02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id4pc3B03
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily10 — Translation factors
Domain ID domain_id4pc3C01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily10 — Ubiquitin-associated (UBA) domain
Domain ID domain_id4pc3C02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology479 — Tetrahydropterin Synthase; Chain A
Homologous superfamily homologous superfamily20 — Elongation factor Ts, dimerisation domain
Domain ID domain_id4pc3C03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology479 — Tetrahydropterin Synthase; Chain A
Homologous superfamily homologous superfamily20 — Elongation factor Ts, dimerisation domain
Domain ID domain_id4pc3C04
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology286 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily20 —
Domain ID domain_id4pc3D01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily10 — Ubiquitin-associated (UBA) domain
Domain ID domain_id4pc3D02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology479 — Tetrahydropterin Synthase; Chain A
Homologous superfamily homologous superfamily20 — Elongation factor Ts, dimerisation domain
Domain ID domain_id4pc3D03
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology479 — Tetrahydropterin Synthase; Chain A
Homologous superfamily homologous superfamily20 — Elongation factor Ts, dimerisation domain
Domain ID domain_id4pc3D04
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology286 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily20 —
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7. Citations (1)