4v8r

The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

T-COMPLEX PROTEIN 1 SUBUNIT ALPHA

SACCHAROMYCES CEREVISIAE

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPA_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain AA； PDBConstruct 1–559； UniProt 1–559 Author chain Aa； PDBConstruct 1–559； UniProt 1–559 Author chain BA； PDBConstruct 1–559； UniProt 1–559 Author chain Ba； PDBConstruct 1–559； UniProt 1–559

T-COMPLEX PROTEIN 1 SUBUNIT BETA

SACCHAROMYCES CEREVISIAE

UniProt P39076

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPB_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain AB； PDBConstruct 1–527； UniProt 1–527 Author chain Ab； PDBConstruct 1–527； UniProt 1–527 Author chain BB； PDBConstruct 1–527； UniProt 1–527 Author chain Bb； PDBConstruct 1–527； UniProt 1–527

T-COMPLEX PROTEIN 1 SUBUNIT DELTA

SACCHAROMYCES CEREVISIAE

UniProt P39078

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPD_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain AD； PDBConstruct 1–528； UniProt 1–528 Author chain Ad； PDBConstruct 1–528； UniProt 1–528 Author chain BD； PDBConstruct 1–528； UniProt 1–528 Author chain Bd； PDBConstruct 1–528； UniProt 1–528

T-COMPLEX PROTEIN 1 SUBUNIT EPSILON

SACCHAROMYCES CEREVISIAE

UniProt P40413

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPE_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain AE； PDBConstruct 1–562； UniProt 1–562 Author chain Ae； PDBConstruct 1–562； UniProt 1–562 Author chain BE； PDBConstruct 1–562； UniProt 1–562 Author chain Be； PDBConstruct 1–562； UniProt 1–562

T-COMPLEX PROTEIN 1 SUBUNIT GAMMA

SACCHAROMYCES CEREVISIAE

UniProt P39077

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPG_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain AG； PDBConstruct 1–374； UniProt 1–374 Author chain AG； PDBConstruct 431–590； UniProt 375–534 Author chain Ag； PDBConstruct 1–374； UniProt 1–374 Author chain Ag； PDBConstruct 431–590； UniProt 375–534 Author chain BG； PDBConstruct 1–374； UniProt 1–374 Author chain BG； PDBConstruct 431–590； UniProt 375–534 Author chain Bg； PDBConstruct 1–374； UniProt 1–374 Author chain Bg； PDBConstruct 431–590； UniProt 375–534

T-COMPLEX PROTEIN 1 SUBUNIT ETA

SACCHAROMYCES CEREVISIAE

UniProt P42943

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPH_YEAST
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain AH； PDBConstruct 1–550； UniProt 1–550 Author chain Ah； PDBConstruct 1–550； UniProt 1–550 Author chain BH； PDBConstruct 1–550； UniProt 1–550 Author chain Bh； PDBConstruct 1–550； UniProt 1–550

T-COMPLEX PROTEIN 1 SUBUNIT THETA

SACCHAROMYCES CEREVISIAE

UniProt P47079

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT ZETA × 2 （P39079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPQ_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain AQ； PDBConstruct 1–568； UniProt 1–568 Author chain Aq； PDBConstruct 1–568； UniProt 1–568 Author chain BQ； PDBConstruct 1–568； UniProt 1–568 Author chain Bq； PDBConstruct 1–568； UniProt 1–568

T-COMPLEX PROTEIN 1 SUBUNIT ZETA

SACCHAROMYCES CEREVISIAE

UniProt P39079

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 16	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA × 2 （P12612） T-COMPLEX PROTEIN 1 SUBUNIT BETA × 2 （P39076） T-COMPLEX PROTEIN 1 SUBUNIT DELTA × 2 （P39078） T-COMPLEX PROTEIN 1 SUBUNIT EPSILON × 2 （P40413） T-COMPLEX PROTEIN 1 SUBUNIT GAMMA × 2 （P39077） T-COMPLEX PROTEIN 1 SUBUNIT ETA × 2 （P42943） T-COMPLEX PROTEIN 1 SUBUNIT THETA × 2 （P47079） ADENOSINE-5'-DIPHOSPHATE × 16 BERYLLIUM TRIFLUORIDE ION × 16 MAGNESIUM ION × 16	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TCPZ_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain AZ； PDBConstruct 1–546； UniProt 1–546 Author chain Az； PDBConstruct 1–546； UniProt 1–546 Author chain BZ； PDBConstruct 1–546； UniProt 1–546 Author chain Bz； PDBConstruct 1–546； UniProt 1–546

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4v8r
Deposition date deposition_date	2012-03-28
Structure title title	The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning
Keywords keywords	CHAPERONE; CHAPERONE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4v8r__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4v8r__assembly_2__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4v8r__assembly_2__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	66.03 Å
Rg (electron density)	64.93 Å
Total Rg	65.06 Å
Atom count	64390
Residues	8358
Excluded volume	1153200 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4v8r__assembly_1__model_1`	hexadecameric （16）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`4v8r__assembly_2__model_1`	hexadecameric （16）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (11)

Entity 1 Entity 1 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT ALPHA
Molecular weight formula_weight	60557.6 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AA,Aa,BA,Ba
Atom count atom_count	128780

MSQLFNNSRSDTLFLGGEKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQHPAGKILVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALREAIRFINEVLSTSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSKGEIKYPVKAVNVLKAHGKSATESLLVPGYALNCTVASQAMPKRIAGGNVKIACLDLNLQKARMAMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEFVEAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDECILIKGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALNIYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPEDVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRIDTMITVDPEPPKEDPHDH

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 2 Entity 2 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT BETA
Molecular weight formula_weight	57276.3 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AB,Ab,BB,Bb

MSVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGNNQPKRIENAKILIANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARPRTANRQHM

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 3 Entity 3 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT DELTA
Molecular weight formula_weight	57740.4 kDa
Mutation mutation	YES
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AD,Ad,BD,Bd

MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLDSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 4 Entity 4 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT EPSILON
Molecular weight formula_weight	61995.0 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AE,Ae,BE,Be

MAARPQQPPMEMPDLSNAIVAQDEMGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGKDEY

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 5 Entity 5 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT GAMMA
Molecular weight formula_weight	64939.8 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AG,Ag,BG,Bg

MQAPVVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQVSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKEPGSGSGWSHPQFEKGSGKRRWKKNFIAVSAANRFKKISSSGALGSGHHHHHHHHGSGKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 6 Entity 6 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT ETA
Molecular weight formula_weight	59802.4 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AH,Ah,BH,Bh

MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQGAGRGRGMPM

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 7 Entity 7 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT THETA
Molecular weight formula_weight	61735.1 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AQ,Aq,BQ,Bq

MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQGPRPGNWDQED

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 8 Entity 8 polymer

Description description	T-COMPLEX PROTEIN 1 SUBUNIT ZETA
Molecular weight formula_weight	59997.6 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AZ,Az,BZ,Bz

MSLQLLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLKETPQ

Source Source

Source organism organism	SACCHAROMYCES CEREVISIAE
Common name common_name	;BAKER'S YEAST ;
NCBI taxonomy ID ncbi_taxonomy_id	4932
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 9 Entity 9 non-polymer

Description description	ADENOSINE-5'-DIPHOSPHATE
Molecular weight formula_weight	427.2 kDa
Source method src_method	syn
Copy count entity_count	32

Entity 10 Entity 10 non-polymer

Description description	BERYLLIUM TRIFLUORIDE ION
Molecular weight formula_weight	66.0 kDa
Source method src_method	syn
Copy count entity_count	32

Entity 11 Entity 11 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	32

▶

Unit-cell length a length_a	159.100 Å
Unit-cell length b length_b	162.540 Å
Unit-cell length c length_c	268.100 Å
Unit-cell angle α angle_alpha	85.23 °
Unit-cell angle β angle_beta	81.15 °
Unit-cell angle γ angle_gamma	61.17 °
Molecules per unit cell Z z_pdb	4

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.800 Å
Low-resolution limit resolution_low	89.950 Å
R factor r_factor	0.2480
R_work r_work	0.2480
R_free r_free	0.2840

The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning

1. Protein Identity and Related Structures Protein Identity & Related Structures

T-COMPLEX PROTEIN 1 SUBUNIT ALPHA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

T-COMPLEX PROTEIN 1 SUBUNIT BETA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

T-COMPLEX PROTEIN 1 SUBUNIT DELTA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

T-COMPLEX PROTEIN 1 SUBUNIT EPSILON

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

T-COMPLEX PROTEIN 1 SUBUNIT GAMMA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

T-COMPLEX PROTEIN 1 SUBUNIT ETA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

T-COMPLEX PROTEIN 1 SUBUNIT THETA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

T-COMPLEX PROTEIN 1 SUBUNIT ZETA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4v8r__assembly_2__model_1

4v8r__assembly_2__model_1 | I(q)

4v8r__assembly_2__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

5. Entities and Polymers Entities & Polymers (11)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer