5mza

The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1

Method: X-RAY DIFFRACTION D_max: 115.0 Å Quality: GOOD

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Erythrocyte membrane protein 1 (PfEMP1)

Plasmodium falciparum 3D7

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	其他组合异源复合物蛋白 × 2 其他聚合物 1 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 A； UniProt 728–1214	片段：UNP Residues 728-1214	Intercellular adhesion molecule 1 × 1 （P05362） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 3PO TRIPHOSPHATE × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；277 K；10% (w/v) PEG 20000, 20% (v/v) PEG 500 and 0.1M Tris-BICINE (pH 8.5)	分辨率 2.78 Å R-free 0.236

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

数据库中没有找到同一 UniProt 蛋白的其他 PDB 条目。

查看构建体与数据证据

UniProt名称	Q8IHM0_PLAF7
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 2–488； UniProt 728–1214

Intercellular adhesion molecule 1

Homo sapiens

UniProt P05362

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	其他组合异源复合物蛋白 × 2 其他聚合物 1 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 B； UniProt 28–212	未记录	Erythrocyte membrane protein 1 (PfEMP1) × 1 （Q8IHM0） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 3PO TRIPHOSPHATE × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, SITTING DROP；277 K；10% (w/v) PEG 20000, 20% (v/v) PEG 500 and 0.1M Tris-BICINE (pH 8.5)	分辨率 2.78 Å R-free 0.236

数据库中的同蛋白其他状态

其他 PDB	相对当前条目 5MZA	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1D3E CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 16 (HRV16) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 300 PDB 声明：300-MERIC	链 1 28–212（185 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV16 WAS INCUBATED WITH D1D2-ICAM-1 FOR 16 HOURS AT 34 DEGREES CELSIUS (307 KELVIN) USING A SIXTEEN-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER	分辨率 28.00 Å
1D3E CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 16 (HRV16) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 信息不足异源复合物；蛋白 × 5 PDB 声明：pentameric	链 1 28–212（185 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV16 WAS INCUBATED WITH D1D2-ICAM-1 FOR 16 HOURS AT 34 DEGREES CELSIUS (307 KELVIN) USING A SIXTEEN-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER	分辨率 28.00 Å
1D3E CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 16 (HRV16) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 信息不足异源复合物；蛋白 × 25 PDB 声明：25-meric	链 1 28–212（185 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV16 WAS INCUBATED WITH D1D2-ICAM-1 FOR 16 HOURS AT 34 DEGREES CELSIUS (307 KELVIN) USING A SIXTEEN-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER	分辨率 28.00 Å
1D3E CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 16 (HRV16) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 信息不足异源复合物；蛋白 × 30 PDB 声明：30-meric	链 1 28–212（185 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV16 WAS INCUBATED WITH D1D2-ICAM-1 FOR 16 HOURS AT 34 DEGREES CELSIUS (307 KELVIN) USING A SIXTEEN-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER	分辨率 28.00 Å
1D3E CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 16 (HRV16) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 信息不足异源复合物；蛋白 × 5 PDB 声明：pentameric	链 1 28–212（185 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV16 WAS INCUBATED WITH D1D2-ICAM-1 FOR 16 HOURS AT 34 DEGREES CELSIUS (307 KELVIN) USING A SIXTEEN-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER	分辨率 28.00 Å
1D3I CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 14 (HRV14) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 300 PDB 声明：300-MERIC	链 I 28–212（185 aa）片段：FIRST TWO DOMAINS, RESIDUES 1-185	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV14 WAS INCUBATED WITH D1D2-ICAM-1 FOR 30 MINUTES AT 4 DEGREES CELSIUS (277 KELVIN) USING AN EIGHT-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER.	分辨率 26.00 Å
1D3I CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 14 (HRV14) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 5 PDB 声明：pentameric	链 I 28–212（185 aa）片段：FIRST TWO DOMAINS, RESIDUES 1-185	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV14 WAS INCUBATED WITH D1D2-ICAM-1 FOR 30 MINUTES AT 4 DEGREES CELSIUS (277 KELVIN) USING AN EIGHT-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER.	分辨率 26.00 Å
1D3I CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 14 (HRV14) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 25 PDB 声明：25-meric	链 I 28–212（185 aa）片段：FIRST TWO DOMAINS, RESIDUES 1-185	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV14 WAS INCUBATED WITH D1D2-ICAM-1 FOR 30 MINUTES AT 4 DEGREES CELSIUS (277 KELVIN) USING AN EIGHT-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER.	分辨率 26.00 Å
1D3I CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 14 (HRV14) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 30 PDB 声明：30-meric	链 I 28–212（185 aa）片段：FIRST TWO DOMAINS, RESIDUES 1-185	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV14 WAS INCUBATED WITH D1D2-ICAM-1 FOR 30 MINUTES AT 4 DEGREES CELSIUS (277 KELVIN) USING AN EIGHT-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER.	分辨率 26.00 Å
1D3I CRYO-EM STRUCTURE OF HUMAN RHINOVIRUS 14 (HRV14) COMPLEXED WITH A TWO-DOMAIN FRAGMENT OF ITS CELLULAR RECEPTOR, INTERCELLULAR ADHESION MOLECULE-1 (D1D2-ICAM-1). IMPLICATIONS FOR VIRUS-RECEPTOR INTERACTIONS. ALPHA CARBONS ONLY 提交 1999-09-29	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 5 PDB 声明：pentameric	链 I 28–212（185 aa）片段：FIRST TWO DOMAINS, RESIDUES 1-185	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5 cryo-EM玻璃化条件 HRV14 WAS INCUBATED WITH D1D2-ICAM-1 FOR 30 MINUTES AT 4 DEGREES CELSIUS (277 KELVIN) USING AN EIGHT-FOLD EXCESS OF D1D2-ICAM-1 FOR EACH OF THE SIXTY POSSIBLE BINDING SITES PER VIRION. AFTER INCUBATION, SAMPLES WERE PREPARED AS THIN LAYERS OF VITREOUS ICE AND MAINTAINED AT NEAR LIQUID NITROGEN TEMPERATURE IN THE ELECTRON MICROSCOPE WITH A GATAN 626 CRYOTRANSFER HOLDER.	分辨率 26.00 Å
1D3L D1D2-ICAM-1 FULLY GLYCOSYLATED, VARIATION OF D1-D2 INTERDOMAIN ANGLE IN DIFFERENT CRYSTAL STRUCTURES. 提交 1999-09-29	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 28–212（185 aa）片段：FIRST TWO DOMAINS, RESIDUES 1-185	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 PROTEIN WAS DESIALATED WITH NEURAMINIDASE (8 HR AT 37 DEGREES IN 100 MM SODIUM ACETATE, PH 6.5, 10 MG/ML PROTEIN, 0.1 ENZYME UNIT/ML), DIALYZED AGAINST 10 MM TRIS, 25 MM NACL (PH 6.0), AND PASSED THROUGH MONO-Q COLUMN. DESIALATED MATERIAL WAS CRYSTALLIZED BY HANGING DROP METHODS: 17 MG/ML PROTEIN IN BUFFER: 10 MM TRIS,25 MM NACL,1 MM MGCL2,1 MM CACL2, WAS PRECIPITATED FROM 24-27% PEG 3350 IN SAME BUFFER.	分辨率 3.25 Å
1IAM STRUCTURE OF THE TWO AMINO-TERMINAL DOMAINS OF HUMAN INTERCELLULAR ADHESION MOLECULE-1, ICAM-1 提交 1998-02-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 28–212（185 aa）片段：TWO N-TERMINAL, IMMUNOGLOBULIN DOMAINS	突变：N103Q, N118Q, N156Q	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 7.5；PROTEIN IN 10 MM TRIS, PH 7.5, 25 MM NACL, WAS CRYSTALLIZED FROM 20% PEG 4000 IN 10 MM TRIS AS PRECIPITANT	分辨率 2.10 Å R-free 0.303
1IC1 THE CRYSTAL STRUCTURE FOR THE N-TERMINAL TWO DOMAINS OF ICAM-1 提交 1998-03-09	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 28–217（190 aa）片段：N-TERMINAL 190 RESIDUE DOMAIN	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；17% PEG 4000, NA CACODYLATE, PH 6.5, AND 100 MM B-OCTYL-GLUCOPYRANOSIDE.	分辨率 3.00 Å R-free 0.279
1IC1 THE CRYSTAL STRUCTURE FOR THE N-TERMINAL TWO DOMAINS OF ICAM-1 提交 1998-03-09	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 其他组合同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 28–217（190 aa）片段：N-TERMINAL 190 RESIDUE DOMAIN	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；17% PEG 4000, NA CACODYLATE, PH 6.5, AND 100 MM B-OCTYL-GLUCOPYRANOSIDE.	分辨率 3.00 Å R-free 0.279
1MQ8 Crystal structure of alphaL I domain in complex with ICAM-1 提交 2002-09-15	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 28–318（291 aa）片段：domains 1 and 2	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；25% PEG 4000, 0.1 M sodium acetate, pH 4.6, VAPOR DIFFUSION, HANGING DROP at 298K	分辨率 3.30 Å R-free 0.313
1MQ8 Crystal structure of alphaL I domain in complex with ICAM-1 提交 2002-09-15	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 其他组合异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 28–318（291 aa）片段：domains 1 and 2	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；25% PEG 4000, 0.1 M sodium acetate, pH 4.6, VAPOR DIFFUSION, HANGING DROP at 298K	分辨率 3.30 Å R-free 0.313
1P53 The Crystal Structure of ICAM-1 D3-D5 fragment 提交 2003-04-24	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 212–477（266 aa）片段：ICAM-1 extracellular Domain 3-5, ecto-fragment	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；15mg/ml protein, NH4H2PO4, 0.1 M Na-citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K	分辨率 3.06 Å R-free 0.252
1P53 The Crystal Structure of ICAM-1 D3-D5 fragment 提交 2003-04-24	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 212–477（266 aa）片段：ICAM-1 extracellular Domain 3-5, ecto-fragment	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；15mg/ml protein, NH4H2PO4, 0.1 M Na-citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K	分辨率 3.06 Å R-free 0.252
1Z7Z Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi 提交 2005-03-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 360 PDB 声明：360-MERIC	链 I 28–477（450 aa）片段：ICAM-1 EXTRACELLULAR DOMAIN 1-5	突变：K29M	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 480	ELECTRON MICROSCOPY cryo-EM缓冲液 TRIS；pH 7.2；TRIS cryo-EM玻璃化条件冷冻剂 ETHANE；PLUNGED INTO ETHANE AT LIQUID NITROGEN TEMPERATURE	分辨率 8.00 Å
1Z7Z Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi 提交 2005-03-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 I 28–477（450 aa）片段：ICAM-1 EXTRACELLULAR DOMAIN 1-5	突变：K29M	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	ELECTRON MICROSCOPY cryo-EM缓冲液 TRIS；pH 7.2；TRIS cryo-EM玻璃化条件冷冻剂 ETHANE；PLUNGED INTO ETHANE AT LIQUID NITROGEN TEMPERATURE	分辨率 8.00 Å
1Z7Z Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi 提交 2005-03-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 30 PDB 声明：30-meric	链 I 28–477（450 aa）片段：ICAM-1 EXTRACELLULAR DOMAIN 1-5	突变：K29M	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 40	ELECTRON MICROSCOPY cryo-EM缓冲液 TRIS；pH 7.2；TRIS cryo-EM玻璃化条件冷冻剂 ETHANE；PLUNGED INTO ETHANE AT LIQUID NITROGEN TEMPERATURE	分辨率 8.00 Å
1Z7Z Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi 提交 2005-03-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 36 PDB 声明：36-meric	链 I 28–477（450 aa）片段：ICAM-1 EXTRACELLULAR DOMAIN 1-5	突变：K29M	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 48	ELECTRON MICROSCOPY cryo-EM缓冲液 TRIS；pH 7.2；TRIS cryo-EM玻璃化条件冷冻剂 ETHANE；PLUNGED INTO ETHANE AT LIQUID NITROGEN TEMPERATURE	分辨率 8.00 Å
1Z7Z Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi 提交 2005-03-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 I 28–477（450 aa）片段：ICAM-1 EXTRACELLULAR DOMAIN 1-5	突变：K29M	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	ELECTRON MICROSCOPY cryo-EM缓冲液 TRIS；pH 7.2；TRIS cryo-EM玻璃化条件冷冻剂 ETHANE；PLUNGED INTO ETHANE AT LIQUID NITROGEN TEMPERATURE	分辨率 8.00 Å
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 10 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 S 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 11 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 U 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 12 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 W 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 13 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 Y 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 14 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 a 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 E 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 4 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 G 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 5 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 I 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 6 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 K 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 7 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 M 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 8 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 O 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
3TCX Structure of Engineered Single Domain ICAM-1 D1 with High-Affinity aL Integrin I Domain of Native C-Terminal Helix Conformation 提交 2011-08-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 9 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 Q 29–112（84 aa）片段：DOMAIN 1, unp residues 29-112	突变：T2V, I10T, T23A, P38V, P63V, S67A, T78A	MG MAGNESIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION；pH 6；277 K；pH 6.0, EVAPORATION, temperature 277K	分辨率 3.60 Å R-free 0.234
6EIT Coxsackievirus A24v in complex with the D1-D2 fragment of ICAM-1 提交 2017-09-19	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 240 PDB 声明：240-meric	链 4 28–112（85 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.5；TBS buffer (Coxsackievirus A24v) Phosphate buffer (ICAM-1 D1-D2) cryo-EM玻璃化条件冷冻剂 ETHANE；On-grid binding of the receptor was performed by applying 3 microliters of ICAM-1 (9.85 mg/ml) to the pre-blotted, virus-containing grid, and leaving for 30 seconds before blotting and freezing	分辨率 3.90 Å
6S8U Structure of the PfEMP1 IT4var13 DBLbeta domain bound to ICAM-1 提交 2019-07-10	配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 28–212（185 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；291 K；0.1M Tris pH 8, 25% PEG 350 MME	分辨率 3.67 Å R-free 0.286
7BG7 HRV14 in complex with its receptor ICAM-1 提交 2021-01-06	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 300 PDB 声明：300-meric	链 B 28–480（453 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4；PBS cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.40 Å

共 12 个其他 PDB 条目、40 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	ICAM1_HUMAN
Isoform	—
PDB实体	2
链与序列区间	作者链 B； PDB构建体 1–185； UniProt 28–212

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	5mza
沉积日期 deposition_date	2017-01-31
结构标题 title	The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1
关键词 keywords	PfEMP1 ICAM-1 Cerebral malaria, Cell adhesion; CELL ADHESION
实验方法 method	X-RAY DIFFRACTION

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3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	31.66 Å
回转半径 Rg (电子) rg_electron	30.78 Å
零角强度 I(0) i0	92418500.00
分子量 molecular_weight	72426.0 kDa
排除体积 excluded_volume	89217 Å³
包络体积 envelope_volume	116340 Å³
水化壳体积 shell_volume	33219 Å³
包络直径 envelope_diameter	122.6 Å
壳层 Rg shell_rg	35.81 Å
包络 Rg envelope_rg	31.18 Å
形状 Rg shape_rg	30.68 Å
总 Rg total_rg	31.53 Å
总原子数 total_atoms	5081
残基数 n_residues	626
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	115.0 Å
Rg (实空间) rg_real	31.81 Å
Rg 误差 (实空间) rg_real_error	1.20 Å
I(0) (实空间) i0_real	9.2420e+07
I(0) 误差 (实空间) i0_real_error	1.3490e+06
Rg (倒空间) rg_reciprocal	31.75 Å
I(0) (倒空间) i0_reciprocal	92410000.0000
解质量估计 total_estimate	0.8556
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	32.2 Å
偏度 Skewness skewness	0.434
峰度 Kurtosis kurtosis	-0.244
角度范围 angular_range	— – 0.2500 Å⁻¹
当前正则化参数 α current_alpha	0.0000
最高正则化参数 α highest_alpha	9867000.0000
实空间数据点数 n_real_points	51
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.759; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.865; Smooth: 0.976

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5. 晶体学与实验 5. Crystallography & Experiment

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6. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

描述 description	Erythrocyte membrane protein 1 (PfEMP1)
分子量 formula_weight	55517.4 kDa
来源方法 src_method	man
拷贝数 entity_count	1

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A
原子数 atom_count	5092

SNPCAKPHGKKLATVKQIAQYYKRKAYIQLNERGSRSALKGDASQGQYDRGGKADDFKTKLCEINEKHSNARSNSLNPCNGKDNNKVRFNVGTPWQSGEKIATATDVYLPPRRQHFCTSNLEYLINGGHQAILNVKNGKINHSFLGDVLLAAKYQAQHTMKDYKSKNDKEGICRAIRYSFADIGDIIKGTDLWDKDGGEIKTQNHLVTIFDKIKAQLPKDIKGKYTGTKHLELRKDWWEANRDQVWKAMQCGNDNPCSGESDHTPLHDYIPQRLRWMTEWAEWYCKEQSRLYDKLKVCEECMRKGESCTKGSGECATCKEACEEYNKEIKKWEQQWDAISYKYLMLYAKARITAINGGPGYYNTEVQEEDKPVVDFLYNLYLQNGGKKGPPPDTHRVKALIARVKRDAARNRVKRADGSSATRVTATTTITPYSTAAGYIHQEAHIGDCQKQTQFCKNKNGSDVSDTEADPTYAFRDKPHDHDTACKC

来源 Source

来源生物 organism	Plasmodium falciparum 3D7
NCBI 分类编号 ncbi_taxonomy_id	36329
宿主生物 host_organism	Escherichia coli

实体 2 Entity 2 polymer

描述 description	Intercellular adhesion molecule 1
分子量 formula_weight	20495.3 kDa
来源方法 src_method	man
拷贝数 entity_count	1

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	B

QTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFG

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	Human
NCBI 分类编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

实体 3 Entity 3 branched

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	424.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

实体 4 Entity 4 non-polymer

描述 description	TRIPHOSPHATE
分子量 formula_weight	258.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

实体 5 Entity 5 non-polymer

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	221.2 kDa
来源方法 src_method	syn
拷贝数 entity_count	2

实体 6 Entity 6 non-polymer

描述 description	INOSITOL HEXAKISPHOSPHATE
分子量 formula_weight	660.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

实体 7 Entity 7 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	11

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7. 折叠分类 (SCOP + CATH) 5 domains

SCOP 2.08 (3 domains)

结构域编号 domain_id	d5mzab1
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamily	b.1.1 — Immunoglobulin
家族 Family family	b.1.1.0 — automated matches

结构域编号 domain_id	d5mzab2
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamily	b.1.1 — Immunoglobulin
家族 Family family	b.1.1.3 — C2 set domains

结构域编号 domain_id	d5mzab3
类 Class class	l — Artifacts
折叠类型 Fold fold	l.1 — Tags
超家族 Superfamily superfamily	l.1.1 — Tags
家族 Family family	l.1.1.1 — Tags

CATH v4.4 (2 domains)

结构域编号 domain_id	5mzaB01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	10 — Immunoglobulins

结构域编号 domain_id	5mzaB02
类 Class class	2 — Mainly Beta
架构 Architecture architecture	60 — Sandwich
拓扑 Topology topology	40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily	10 — Immunoglobulins

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8. 引用文献 (1)

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晶胞边长 a length_a	68.639 Å
晶胞边长 b length_b	109.830 Å
晶胞边长 c length_c	112.830 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	4

空间群 space_group	P 21 21 21
空间群编号 int_tables_number	19
晶系 crystal_system	—

分辨率 resolution	2.780 Å
最低分辨率 resolution_low	30.190 Å
R 因子 r_factor	0.2063
R_work r_work	0.2048
R_free r_free	0.2356

fit	/app/data/saxs_computation/mz/5mza/5mza.fit
pddf	/app/data/pr_computation/mz/5mza/5mza.pr.out
profile	/app/data/saxs_computation/mz/5mza/5mza.dat

The DBLb domain of PF11_0521 PfEMP1 bound to human ICAM-1

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Erythrocyte membrane protein 1 (PfEMP1)

当前结构中的状态

数据库中的同蛋白其他状态

Intercellular adhesion molecule 1

当前结构中的状态

数据库中的同蛋白其他状态

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

2. 结构基本信息 2. Structure Basics

3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

5. 晶体学与实验 5. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

6. 实体与聚合物信息 Entities & Polymers (7)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

实体 3 Entity 3 branched

实体 4 Entity 4 non-polymer

实体 5 Entity 5 non-polymer

实体 6 Entity 6 non-polymer

实体 7 Entity 7 water

7. 折叠分类 (SCOP + CATH) 5 domains

SCOP 2.08 (3 domains)

CATH v4.4 (2 domains)

8. 引用文献 (1)

9. 文件与曲线 (10)

Files (7)

Curves (3)