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6azw

IDO1/FXB-001116 crystal structure

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Indoleamine 2,3-dioxygenase 1

Homo sapiens

UniProt P14902

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2d0t 2d0t 2d0u 2d0u 4u72 4u72 4u74 4u74 5ek2 5ek2 5ek3 5ek3

155 assemblies; showing the first 12

Homodimer
4pk5 4pk6 5etw 5whr 5xe1 6e35 6r63 6v52 7ah4 7ah5 7ah6 7b1o

21 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name I23O1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–394； UniProt 11–403 Author chain B； PDBConstruct 2–394； UniProt 11–403

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6azw
Deposition date deposition_date2017-09-13
Structure title titleIDO1/FXB-001116 crystal structure
Keywords keywordsIDO1/FXB-001116 crystal structure, oxidoreductase-oxidoreductase inhibitor complex; oxidoreductase/oxidoreductase inhibitor
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6azw__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6azw__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6azw__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.13 Å
Rg (electron density)20.96 Å
Total Rg21.86 Å
Atom count5469
Residues373
Excluded volume50371 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6azw__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6azw__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd6azwa_
Class classa — All alpha proteins
Fold Fold folda.266 — Indolic compounds 2,3-dioxygenase-like
Superfamily Superfamily superfamilya.266.1 — Indolic compounds 2,3-dioxygenase-like
Family Family familya.266.1.2 — Indoleamine 2,3-dioxygenase-like
Domain ID domain_idd6azwb_
Class classa — All alpha proteins
Fold Fold folda.266 — Indolic compounds 2,3-dioxygenase-like
Superfamily Superfamily superfamilya.266.1 — Indolic compounds 2,3-dioxygenase-like
Family Family familya.266.1.2 — Indoleamine 2,3-dioxygenase-like
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7. Citations (1)