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6e0q

The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Polymerase acidic protein

Influenza A virus

UniProt C3W5S0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 MANGANESE (II) ION × 2 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid × 1 1,2-ETHANEDIOL × 2 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
29sj 29sj 29sl 29sl 4avg 4avg 4avg 4avg 4avl 4avl 4avl 4avl

117 assemblies; showing the first 12

Homodimer
5wcs 5wct 5we9

3 assemblies

Homotetramer
5dbs 5vp8 5vpt 5vrj 5w92 5w9g 5wb3 5wfz 7rkp

9 assemblies

Other homooligomers
7ml8 7mty 7mx0 7my5 7n47 7n55 7n68 7n8f

8 assemblies

Heteromeric or nucleic-acid complex
9fxx

1 assemblies

View Construct and Data Evidence
UniProt name C3W5S0_I09A0
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–192； UniProt 1–198

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6e0q
Deposition date deposition_date2018-07-06
Structure title titleThe N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid
Keywords keywordsInhibitor, Endonuclease, Influenza, PA domain, HYDROLASE-HYDROLASE INHIBITOR complex, VIRAL PROTEIN; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6e0q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6e0q__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6e0q__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.13 Å
Rg (electron density)15.94 Å
Total Rg16.94 Å
Atom count1503
Residues178
Excluded volume26721 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6e0q__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd6e0qa1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.52 — Restriction endonuclease-like
Superfamily Superfamily superfamilyc.52.1 — Restriction endonuclease-like
Family Family familyc.52.1.34 — PA N-terminal domain
Domain ID domain_idd6e0qa2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (1 domains)

Domain ID domain_id6e0qA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology91 — Restriction Endonuclease
Homologous superfamily homologous superfamily90 — Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
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7. Citations (1)