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6fof

Crystal structure of a crystallized variant of h-Gal3: Gal-3[NTS/VII-IX]

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Galectin-3,Galectin-3

Homo sapiens

UniProt P17931

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Homooligomer Protein 4 其他Polymer 4 beta-D-galactopyranose-(1-4)-beta-D-glucopyranose × 4 SULFATE ION × 10 water × 4 Consistent with protein count
2 Other combination Homooligomer Protein 4 其他Polymer 4 beta-D-galactopyranose-(1-4)-beta-D-glucopyranose × 4 SULFATE ION × 7 water × 4 Consistent with protein count
3 Other combination Homooligomer Protein 4 其他Polymer 4 beta-D-galactopyranose-(1-4)-beta-D-glucopyranose × 4 SULFATE ION × 7 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
28vw 3ayc 3t1l 3t1m 3zsk 3zsl 3zsm 4bli 4blj 4bm8 5e88 5e89

105 assemblies; showing the first 12

Homodimer
8itx 8itx

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1a3k 1kjl 1kjr 28vp 2nmn 2nmo 2nn8 2xg3 3aya 3aya 3ayc 3ayd

58 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name LEG3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–21； UniProt 2–22 Author chain A； PDBConstruct 22–196； UniProt 76–250 Author chain B； PDBConstruct 1–21； UniProt 2–22 Author chain B； PDBConstruct 22–196； UniProt 76–250 Author chain C； PDBConstruct 1–21； UniProt 2–22 Author chain C； PDBConstruct 22–196； UniProt 76–250 Author chain D； PDBConstruct 1–21； UniProt 2–22 Author chain D； PDBConstruct 22–196； UniProt 76–250 Author chain E； PDBConstruct 1–21； UniProt 2–22 Author chain E； PDBConstruct 22–196； UniProt 76–250 Author chain F； PDBConstruct 1–21； UniProt 2–22 Author chain F； PDBConstruct 22–196； UniProt 76–250 Author chain G； PDBConstruct 1–21； UniProt 2–22 Author chain G； PDBConstruct 22–196； UniProt 76–250 Author chain H； PDBConstruct 1–21； UniProt 2–22 Author chain H； PDBConstruct 22–196； UniProt 76–250 Author chain I； PDBConstruct 1–21； UniProt 2–22 Author chain I； PDBConstruct 22–196； UniProt 76–250 Author chain J； PDBConstruct 1–21； UniProt 2–22 Author chain J； PDBConstruct 22–196； UniProt 76–250 Author chain K； PDBConstruct 1–21； UniProt 2–22 Author chain K； PDBConstruct 22–196； UniProt 76–250 Author chain L； PDBConstruct 1–21； UniProt 2–22 Author chain L； PDBConstruct 22–196； UniProt 76–250

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6fof
Deposition date deposition_date2018-02-07
Structure title titleCrystal structure of a crystallized variant of h-Gal3: Gal-3[NTS/VII-IX]
Keywords keywordsGalectin, apoptosis, glycosylation, sugar binding protein; SUGAR BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6fof__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6fof__assembly_3__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6fof__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.32 Å
Rg (electron density)25.03 Å
Total Rg26.04 Å
Atom count4559
Residues552
Excluded volume81212 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6fof__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6fof__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6fof__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 22 domains

SCOP 2.08 (10 domains)

Domain ID domain_idd6fofb_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofc_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofd_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofe_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofg_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofh_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofi_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofj_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofk_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)
Domain ID domain_idd6fofl_
Class classb — All beta proteins
Fold Fold foldb.29 — Concanavalin A-like lectins/glucanases
Superfamily Superfamily superfamilyb.29.1 — Concanavalin A-like lectins/glucanases
Family Family familyb.29.1.3 — Galectin (animal S-lectin)

CATH v4.4 (12 domains)

Domain ID domain_id6fofA00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofB00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofC00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofD00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofE00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofF00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofG00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofH00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofI00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofJ00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofK00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
Domain ID domain_id6fofL00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily200 —
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7. Citations (1)