Hemoglobin subunit alpha
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain A； UniProt 1–142 Chain C； UniProt 1–142 | Not recorded | Hemoglobin subunit beta × 2 （P68871） HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 | X-RAY DIFFRACTION X-ray crystallization conditions：LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES | Resolution 2.28 Å R-free 0.268 |
| 2 | Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain E； UniProt 1–142 Chain G； UniProt 1–142 | Not recorded | Hemoglobin subunit beta × 2 （P68871） HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 | X-RAY DIFFRACTION X-ray crystallization conditions：LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES | Resolution 2.28 Å R-free 0.268 |
| 3 | Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain I； UniProt 1–142 Chain K； UniProt 1–142 | Not recorded | Hemoglobin subunit beta × 2 （P68871） HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 | X-RAY DIFFRACTION X-ray crystallization conditions：LIQUID DIFFUSION；pH 6；293 K；NaCl, PEG3350, MES | Resolution 2.28 Å R-free 0.268 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 6KYE | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1A00 HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 TYR) MUTANT Deposited 1997-12-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
|
Resolution 2.00 Å R-free 0.223 |
| 1A01 HEMOGLOBIN (VAL BETA1 MET, TRP BETA37 ALA) MUTANT Deposited 1997-12-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
|
Resolution 1.80 Å R-free 0.223 |
| 1A0U HEMOGLOBIN (VAL BETA1 MET) MUTANT Deposited 1997-12-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
|
Resolution 2.14 Å R-free 0.239 |
| 1A0Z HEMOGLOBIN (VAL BETA1 MET) MUTANT Deposited 1997-12-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；10.5% PEG 6000 10 MM POTASSIUM PHOSPHATE PH 7.0 100 MM POTASSIUM CHLORIDE 3 MM SODIUM DITHIONITE
|
Resolution 2.00 Å |
| 1A3N DEOXY HUMAN HEMOGLOBIN Deposited 1998-01-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.220 |
| 1A3O ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN Deposited 1998-01-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：CHAIN A, C, Y42H Mutation：CHAIN A, C, Y42H | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.227 |
| 1A9W HUMAN EMBRYONIC GOWER II CARBONMONOXY HEMOGLOBIN Deposited 1998-04-11 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microseeding and macroseeding used to increase crystal size；pH 8.5；PROTEIN WAS CRYSTALLIZED FROM 21% MME-PEG 5000, 0.2M TAPS/ KOH, PH 8.5, 2MM DITHIONITE. THEN MICROSEEDING AND MACROSEEDING USED TO INCREASE CRYSTAL SIZE, microseeding and macroseeding used to increase crystal size
|
Resolution 2.90 Å R-free 0.232 |
| 1ABW DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 1997-01-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：CHAIN A IS COMPOSED OF TWO COPIES OF HEMOGLOBIN ALPHA CHAIN JOINED BY AN ADDITIONAL RESIDUE, GLY 142 | MET METHIONINE × 2 LEU LEUCINE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.2；pH 6.2
|
Resolution 2.00 Å R-free 0.232 |
| 1ABY CYANOMET RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 1997-01-29 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：CHAIN A, V1M, CHAIN B, D, V1M, N108K | CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；pH 5.0
|
Resolution 2.60 Å R-free 0.278 |
| 1AJ9 R-STATE HUMAN CARBONMONOXYHEMOGLOBIN ALPHA-A53S Deposited 1997-05-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Mutation：A53S | PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch method；pH 6.7；PROTEIN WAS BATCH CRYSTALLIZED IN 2.5 M SODIUM/POTASSIUM PHOSPHATE, PH 6.7, AND 1% (W/V) CARBOXYHEMOGLOBIN., batch method
|
Resolution 2.20 Å |
| 1B86 HUMAN DEOXYHAEMOGLOBIN-2,3-DIPHOSPHOGLYCERATE COMPLEX Deposited 1999-02-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 DG2 (2R)-2,3-diphosphoglyceric acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.2；pH 7.2
|
Resolution 2.50 Å |
| 1BAB HEMOGLOBIN THIONVILLE: AN ALPHA-CHAIN VARIANT WITH A SUBSTITUTION OF A GLUTAMATE FOR VALINE AT NA-1 AND HAVING AN ACETYLATED METHIONINE NH2 TERMINUS Deposited 1992-05-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1BBB A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION Deposited 1992-04-29 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
| 1BIJ CROSSLINKED, DEOXY HUMAN HEMOGLOBIN A Deposited 1998-06-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.30 Å R-free 0.263 |
| 1BUW CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A Deposited 1998-09-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；1% PROTEIN 100 MM SODIUM CACODYLATE, PH 5.8 16% PEG 6000
|
Resolution 1.90 Å R-free 0.244 |
| 1BZ0 HEMOGLOBIN A (HUMAN, DEOXY, HIGH SALT) Deposited 1998-11-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
|
Resolution 1.50 Å R-free 0.208 |
| 1BZ1 HEMOGLOBIN (ALPHA + MET) VARIANT Deposited 1998-11-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE
|
Resolution 1.59 Å R-free 0.224 |
| 1BZZ HEMOGLOBIN (ALPHA V1M) MUTANT Deposited 1998-11-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M Mutation：V1M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；2.3 M AMMONIUM SULFATE 0.3 M AMMONIUM PHOSPHATE PH 6.5 10 MM FERROUS CITRATE, pH 7.0
|
Resolution 1.59 Å R-free 0.214 |
| 1C7B DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M Mutation：V1M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
|
Resolution 1.80 Å R-free 0.234 |
| 1C7C DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：V1M,142G | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
|
Resolution 1.80 Å R-free 0.227 |
| 1C7D DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN) Deposited 2000-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：V1M,142G,143G | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；PERUTZ, J.CRYST.GROWTH 2(1968)54-56, pH 6.5
|
Resolution 1.80 Å R-free 0.240 |
| 1CLS CROSS-LINKED HUMAN HEMOGLOBIN DEOXY Deposited 1995-08-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 O OXYGEN ATOM × 2 SO4 SULFATE ION × 2 DEC SEBACIC ACID × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1CMY THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN Deposited 1992-09-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 3.00 Å |
| 1COH STRUCTURE OF HAEMOGLOBIN IN THE DEOXY QUATERNARY STATE WITH LIGAND BOUND AT THE ALPHA HAEMS Deposited 1989-01-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 COH PROTOPORPHYRIN IX CONTAINING CO × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.90 Å |
| 1DKE NI BETA HEME HUMAN HEMOGLOBIN Deposited 1999-12-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；294 K；24 MG/ML PROTEIN 21% PEG 1000 10MM POTASSIUM PHOSPHATE, 1MM IHP, 30MM SODIUM DITHIONITE, pH 7, VAPOR DIFFUSION,
HANGING DROP
|
Resolution 2.10 Å R-free 0.280 |
| 1DXT HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
| 1DXU HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
| 1DXV HIGH-RESOLUTION X-RAY STUDY OF DEOXY RECOMBINANT HUMAN HEMOGLOBINS SYNTHESIZED FROM BETA-GLOBINS HAVING MUTATED AMINO TERMINI Deposited 1992-05-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
| 1FDH STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN Deposited 1976-08-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain B
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1FN3 CRYSTAL STRUCTURE OF NICKEL RECONSTITUTED HEMOGLOBIN-A CASE FOR PERMANENT, T-STATE HEMOGLOBIN Deposited 2000-08-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.2；pH 7.20
|
Resolution 2.48 Å R-free 0.324 |
| 1G9V HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR Deposited 2000-11-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 RQ3 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；Ammonium sulfate, ammonium phosphate, ferrous citrate, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.85 Å R-free 0.208 |
| 1GBU DEOXY (BETA-(C93A,C112G)) HUMAN HEMOGLOBIN Deposited 1996-01-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：CHAIN B, D, C93A, C112G Mutation：CHAIN B, D, C93A, C112G | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 1GBV (ALPHA-OXY, BETA-(C112G)DEOXY) T-STATE HUMAN HEMOGLOBIN Deposited 1995-12-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：CHAIN B, D, C112G Mutation：CHAIN B, D, C112G | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1GLI DEOXYHEMOGLOBIN T38W (ALPHA CHAINS), V1G (ALPHA AND BETA CHAINS) Deposited 1996-02-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Mutation：V1M, CHAIN A, C, T38W Mutation：V1M, CHAIN A, C, T38W | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1GZX Oxy T State Haemoglobin - Oxygen bound at all four haems Deposited 2002-06-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.2；BATCH CRYSTALLISATION, OXYHB (75-90 MG/ML) IN 50MM POTASSIUM PHOSPHATE (PH 7.2), 22-28% PEG 8000 AND A 5 MOLAR EXCESS OF THE ALLOSTERIC EFFECTOR IHP
|
Resolution 2.10 Å R-free 0.221 |
| 1HAB CROSSLINKED HAEMOGLOBIN Deposited 1996-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 CIN 4-CARBOXYCINNAMIC ACID × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1HAC CROSSLINKED HAEMOGLOBIN Deposited 1996-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 NDD 2,6-DICARBOXYNAPHTHALENE × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.60 Å |
| 1HBA HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE Deposited 1992-01-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.10 Å |
| 1HBB HIGH-RESOLUTION X-RAY STUDY OF DEOXYHEMOGLOBIN ROTHSCHILD 37BETA TRP-> ARG: A MUTATION THAT CREATES AN INTERSUBUNIT CHLORIDE-BINDING SITE Deposited 1992-01-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1HBS REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION Deposited 1982-06-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 3.00 Å |
| 1HBS REFINED CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S. I. RESTRAINED LEAST-SQUARES REFINEMENT AT 3.0-ANGSTROMS RESOLUTION Deposited 1982-06-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 3.00 Å |
| 1HCO THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION Deposited 1979-08-07 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.70 Å |
| 1HGA HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.10 Å |
| 1HGB HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.10 Å |
| 1HGC HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN Deposited 1991-10-31 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.10 Å |
| 1HHO STRUCTURE OF HUMAN OXYHAEMOGLOBIN AT 2.1 ANGSTROMS RESOLUTION Deposited 1983-06-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.10 Å |
| 1IRD Crystal Structure of Human Carbonmonoxy-Haemoglobin at 1.25 A Resolution Deposited 2001-09-27 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.7；298 K；potassium phosphate, pH 6.7, SMALL TUBES, temperature 298K
|
Resolution 1.25 Å R-free 0.214 |
| 1J3Y Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
|
Resolution 1.55 Å R-free 0.205 |
| 1J3Y Direct observation of photolysis-induced tertiary structural changes in human hemoglobin; Crystal structure of alpha(Fe)-beta(Ni) hemoglobin (laser photolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
|
Resolution 1.55 Å R-free 0.205 |
| 1J3Z Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
|
Resolution 1.60 Å R-free 0.196 |
| 1J3Z Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Fe-CO)-beta(Ni) hemoglobin (laser unphotolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, SMALL TUBES, temperature 293K, pH 6.60
|
Resolution 1.60 Å R-free 0.196 |
| 1J40 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
|
Resolution 1.45 Å R-free 0.197 |
| 1J40 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe-CO) hemoglobin (laser unphotolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
|
Resolution 1.45 Å R-free 0.197 |
| 1J41 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
|
Resolution 1.45 Å R-free 0.195 |
| 1J41 Direct observation of photolysis-induced tertiary structural changes in human haemoglobin; Crystal structure of alpha(Ni)-beta(Fe) hemoglobin (laser photolysed) Deposited 2003-02-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 3 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.6；293 K；PEG 4000, 50mM citrate-ammonium buffer, pH 6.6, SMALL TUBES, temperature 293K
|
Resolution 1.45 Å R-free 0.195 |
| 1J7S Crystal Structure of deoxy HbalphaYQ, a mutant of HbA Deposited 2001-05-18 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Mutation：V1M,L29Y,H54Q Mutation：V1M,L29Y,H54Q | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.7；293 K；Ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 293K
|
Resolution 2.20 Å R-free 0.210 |
| 1J7W Crystal structure of deoxy HbbetaYQ, a site directed mutant of HbA Deposited 2001-05-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Mutation：V1M Mutation：V1M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.7；298 K；ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 298.0K
|
Resolution 2.00 Å R-free 0.223 |
| 1J7Y Crystal structure of partially ligated mutant of HbA Deposited 2001-05-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Mutation：V1M, L29Y, H54Q Mutation：V1M, L29Y, H54Q | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 CMO CARBON MONOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.7；298 K；ammonium sulphate, ammonium phosphate, pH 6.7, SMALL TUBES, temperature 298.0K
|
Resolution 1.70 Å R-free 0.201 |
| 1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
|
Resolution 3.20 Å R-free 0.245 |
| 1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
1–141（141 aa）
Chain R
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
|
Resolution 3.20 Å R-free 0.245 |
| 1JY7 THE STRUCTURE OF HUMAN METHEMOGLOBIN. THE VARIATION OF A THEME Deposited 2001-09-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain U
1–141（141 aa）
Chain W
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；293 K；PEG 4000, Sodium potassium phosphate, pH 6.7, LIQUID DIFFUSION at 293K
|
Resolution 3.20 Å R-free 0.245 |
| 1K0Y X-ray Crystallographic Analyses of Symmetrical Allosteric Effectors of Hemoglobin. Compounds Designed to Link Primary and Secondary Binding Sites Deposited 2001-09-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 CNO 2-{4-[(3{2-[4-(1-CARBOXY-1-METHYL-ETHOXY)-PHENYL]-ACETYLAMINO}-PHENYLCARBAMOYL)-METHYL]-PHENOXY}-2-METHYL-PROPIONIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；Ammonium sulfate, ammonium phosphate, ferrous citrate, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.87 Å R-free 0.189 |
| 1K1K Structure of Mutant Human Carbonmonoxyhemoglobin C (beta E6K) at 2.0 Angstrom Resolution in Phosphate Buffer. Deposited 2001-09-25 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch method；pH 7.35；310 K；potassium phosphate 1.75M, pH 7.35, batch method, temperature 310K
|
Resolution 2.00 Å R-free 0.238 |
| 1KD2 Crystal Structure of Human Deoxyhemoglobin in Absence of Any Anions Deposited 2001-11-12 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH METHOD；pH 7；298 K；DEIONIZED PEG 3350 12.5%, pH 7.0, BATCH METHOD, temperature 298K
|
Resolution 1.87 Å R-free 0.250 |
| 1LFL DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
|
Resolution 2.70 Å R-free 0.263 |
| 1LFL DEOXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain P
1–141（141 aa）
Chain R
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
|
Resolution 2.70 Å R-free 0.263 |
| 1LFQ OXY HEMOGLOBIN (93% RELATIVE HUMIDITY) Deposited 2002-04-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
|
Resolution 2.60 Å R-free 0.258 |
| 1LFT OXY HEMOGLOBIN (90% RELATIVE HUMIDITY) Deposited 2002-04-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
|
Resolution 2.60 Å R-free 0.265 |
| 1LFV OXY HEMOGLOBIN (88% RELATIVE HUMIDITY) Deposited 2002-04-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
|
Resolution 2.80 Å R-free 0.270 |
| 1LFY OXY HEMOGLOBIN (84% RELATIVE HUMIDITY) Deposited 2002-04-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
|
Resolution 3.30 Å R-free 0.261 |
| 1LFZ OXY HEMOGLOBIN (25% METHANOL) Deposited 2002-04-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；phosphate buffer, pH 6.7, LIQUID DIFFUSION at 298K
|
Resolution 3.10 Å R-free 0.268 |
| 1LJW Crystal Structure of Human Carbonmonoxy Hemoglobin at 2.16 A: A Snapshot of the Allosteric Transition Deposited 2002-04-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.4；298 K；Potassium phosphate, Sodium phosphate, toluene, hemoglobin, pH 6.4, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.16 Å R-free 0.259 |
| 1M9P Crystalline Human Carbonmonoxy Hemoglobin C Exhibits The R2 Quaternary State at Neutral pH In The Presence of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure Deposited 2002-07-29 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.1；298 K；21% Polyethylene glycol, 0.150M HEPES-Na, chloride anion traces, pH 7.1, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.269 |
| 1MKO A Fourth Quaternary Structure of Human Hemoglobin A at 2.18 A Resolution Deposited 2002-08-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | PO4 PHOSPHATE ION × 3 CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.4；298 K；potassium and sodium phosphate, toluene, hemoglobin, pH 6.4, LIQUID DIFFUSION at 298K
|
Resolution 2.18 Å R-free 0.284 |
| 1NEJ Crystalline Human Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Exhibits The R2 Quaternary State At Neutral pH In The Presence Of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure Deposited 2002-12-11 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.1；298 K；25% PEG 4000, 0.15M HEPES-Na,chloride anion traces; pH 7.1,
VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 298K
|
Resolution 2.10 Å R-free 0.268 |
| 1NIH Structure of deoxy-quaternary haemoglobin with liganded beta subunits Deposited 1990-03-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.60 Å |
| 1NQP Crystal structure of Human hemoglobin E at 1.73 A resolution Deposited 2003-01-22 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain not uniquely mapped
Reference range not declared
Chain A
1–141（141 aa）
|
Not recorded | CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；PEG and Glycerol, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.73 Å R-free 0.211 |
| 1O1I Cyanomet hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W) Deposited 2002-11-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Mutation：V1M, L29F, H58Q | CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.7；pH 6.70
|
Resolution 2.30 Å R-free 0.267 |
| 1O1J Deoxy hemoglobin (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W) Deposited 2002-11-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：V1M, L29F, H58Q | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.90 Å R-free 0.229 |
| 1O1K Deoxy hemoglobin (A,C:V1M; B,D:V1M,V67W) Deposited 2002-11-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M Mutation：V1M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 2.00 Å R-free 0.249 |
| 1O1L Deoxy hemoglobin (A-GLY-C:V1M,L29W,H58Q; B,D:V1M) Deposited 2002-11-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：V1M, L29W, H58Q | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.80 Å R-free 0.254 |
| 1O1M Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29F,H58Q B,D:V1M,V67W) Deposited 2002-11-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：V1M, L29F, H58Q | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.85 Å R-free 0.250 |
| 1O1N Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29W; B,D:V1M) Deposited 2002-11-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.80 Å R-free 0.242 |
| 1O1O Deoxy hemoglobin (A,C:V1M,V62L; B,D:V1M,V67L) Deposited 2002-11-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, V62L Mutation：V1M, V62L | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.80 Å R-free 0.222 |
| 1O1P Deoxy hemoglobin (A-GLY-C:V1M; B,D:V1M,C93A,N108K) Deposited 2002-11-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
1–141（141 aa）
|
Mutation：V1M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.80 Å R-free 0.245 |
| 1QI8 DEOXYGENATED STRUCTURE OF A DISTAL POCKET HEMOGLOBIN MUTANT Deposited 1999-06-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Fragment：ALPHA CHAIN
Chain C
1–141（141 aa）
Fragment：ALPHA CHAIN
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；HIGH SALT (PERUTZ, 1968)., pH 6.5
|
Resolution 1.80 Å R-free 0.222 |
| 1QSH MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME Deposited 1999-06-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 HEG PROTOPORPHYRIN IX CONTAINING MG × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
Batch Method；pH 6.5；298 K；Ammonium sulfate , pH 6.5, Batch Method, temperature 298K
|
Resolution 1.70 Å |
| 1QSI MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME Deposited 1999-06-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HEG PROTOPORPHYRIN IX CONTAINING MG × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH METHOD；pH 6.5；298 K；AMMONIUM SULFATE, pH 6.5, BATCH METHOD, temperature 298K
|
Resolution 1.70 Å |
| 1QXD Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Not recorded | SO4 SULFATE ION × 7 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FU2 FURFURAL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.25 Å R-free 0.274 |
| 1QXD Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Not recorded | SO4 SULFATE ION × 14 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FU2 FURFURAL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.25 Å R-free 0.274 |
| 1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Not recorded | SO4 SULFATE ION × 7 OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FUX 5-HYDROXYMETHYL-FURFURAL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.85 Å R-free 0.223 |
| 1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Not recorded | SO4 SULFATE ION × 14 OXY OXYGEN MOLECULE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FUX 5-HYDROXYMETHYL-FURFURAL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.85 Å R-free 0.223 |
| 1QXE Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds Deposited 2003-09-05 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–141（141 aa）
Fragment：alpha chain
Chain C
1–141（141 aa）
Fragment：alpha chain
|
Not recorded | SO4 SULFATE ION × 14 OXY OXYGEN MOLECULE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 8 FUX 5-HYDROXYMETHYL-FURFURAL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；ammonium phosphate and sulfate, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.85 Å R-free 0.223 |
| 1R1X Crystal structure of oxy-human hemoglobin Bassett at 2.15 angstrom Deposited 2003-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Mutation：D94A | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；potassium/Sodium phosphate, toluene, hemoglobin, pH 6.7, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.15 Å R-free 0.288 |
| 1R1Y Crystal structure of deoxy-human hemoglobin Bassett at 1.8 angstrom Deposited 2003-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：D94A Mutation：D94A | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；Ammonium phosphate/sulfate, iron citrate, sodium dithionite, deoxyhemoglobin, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.80 Å R-free 0.236 |
| 1RPS Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Hemoglobin exposed to NO under anerobic conditions Deposited 2003-12-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10 mg/mL
human hemoglobin, 10 mM potassium phosphate, 100 mM potassium chloride, 10-12% PEG 6000, 3
mM sodium dithionite (under anaerobic conditions), BATCH METHOD, temperature 298K, pH 7
|
Resolution 2.11 Å R-free 0.232 |
| 1RQ3 Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Deoxyhemoglobin, Deoxyhemoglobin Deposited 2003-12-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 1.91 Å R-free 0.198 |
| 1RQ4 Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin, HEMOGLOBIN EXPOSED TO NO UNDER AEROBIC CONDITIONS Deposited 2003-12-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.11 Å R-free 0.241 |
| 1RQA Crystallographic Analysis of the Interaction of Nitric Oxide with Quaternary-T Human Hemoglobin. Beta W73E hemoglobin exposed to NO under anaerobic conditions Deposited 2003-12-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO NITRIC OXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10 mg/mL human hemoglobin, 10 mM potassium phosphate, 100 mM potassium chloride, 10-12% PEG 6000, 3mM sodium dithionite (under anaerobic conditions), pH 7.0, BATCH METHOD, temperature 298K
|
Resolution 2.11 Å R-free 0.231 |
| 1RVW R STATE HUMAN HEMOGLOBIN [ALPHA V96W], CARBONMONOXY Deposited 1997-03-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Mutation：CHAIN A, V96W | PO4 PHOSPHATE ION × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SDK CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 1SDK CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 8 CMO CARBON MONOXIDE × 8 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 1SDL CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 1SDL CROSS-LINKED, CARBONMONOXY HEMOGLOBIN A Deposited 1996-02-26 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 8 CMO CARBON MONOXIDE × 8 TMM 1,3,5-BENZENETRICARBOXYLIC ACID × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 1SHR Crystal structure of ferrocyanide bound human hemoglobin A2 at 1.88A resolution Deposited 2004-02-26 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | CYN CYANIDE ION × 10 FE FE (III) ION × 3 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；PEG, glycerol, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 1.88 Å R-free 0.195 |
| 1SI4 Crystal structure of Human hemoglobin A2 (in R2 state) at 2.2 A resolution Deposited 2004-02-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | CYN CYANIDE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；PEG, Glycerol, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.20 Å R-free 0.258 |
| 1THB REFINEMENT OF A PARTIALLY OXYGENATED T STATE HAEMOGLOBIN AT 1.5 ANGSTROMS RESOLUTION Deposited 1990-01-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 IHP INOSITOL HEXAKISPHOSPHATE × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1UIW Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2 Deposited 2003-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.6；293 K；PEG6000, pH 6.60, SMALL TUBES, temperature 293K
|
Resolution 1.50 Å R-free 0.205 |
| 1UIW Crystal Structures of Unliganded and Half-Liganded Human Hemoglobin Derivatives Cross-Linked between Lys 82beta1 and Lys 82beta2 Deposited 2003-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.6；293 K；PEG6000, pH 6.60, SMALL TUBES, temperature 293K
|
Resolution 1.50 Å R-free 0.205 |
| 1VWT T STATE HUMAN HEMOGLOBIN [ALPHA V96W], ALPHA AQUOMET, BETA DEOXY Deposited 1997-03-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：CHAIN A, C, V96W Mutation：CHAIN A, C, V96W | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1XXT The T-to-T High Transitions in Human Hemoglobin: wild-type deoxy Hb A (low salt, one test set) Deposited 2004-11-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml hemoglobin, pH 7.0, BATCH, temperature 298K
|
Resolution 1.91 Å R-free 0.239 |
| 1XY0 T-to-THigh Transitions in Human Hemoglobin: alphaK40G deoxy low-salt Deposited 2004-11-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：K40G, V1M Mutation：K40G, V1M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.99 Å R-free 0.260 |
| 1XZ5 T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaL91A deoxy low-salt Deposited 2004-11-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, L91A Mutation：V1M, L91A | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM ammonium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.11 Å R-free 0.248 |
| 1XZ7 T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaR92A deoxy low-salt Deposited 2004-11-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, R92A Mutation：V1M, R92A | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.90 Å R-free 0.203 |
| 1XZU T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaD94G deoxy low-salt Deposited 2004-11-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, D94G Mutation：V1M, D94G | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM ammonium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature , temperature 298K
|
Resolution 2.16 Å R-free 0.260 |
| 1XZV T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaP95A deoxy low-salt Deposited 2004-11-12 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, P95A Mutation：V1M, P95A | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.11 Å R-free 0.246 |
| 1Y01 Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin Deposited 2004-11-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 OXY OXYGEN MOLECULE × 1 CHK 6-[(CYCLOHEXYLACETYL)(2-HYDROXYETHYL)AMINO]-6-DEOXY-D-XYLO-HEXITOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG2000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.292 |
| 1Y09 T-to-T(High) Quaternary Transitions in Human Hemoglobin: alphaN97A deoxy low-salt Deposited 2004-11-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, N97A Mutation：V1M, N97A | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.25 Å R-free 0.206 |
| 1Y0A T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140A deoxy low-salt Deposited 2004-11-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, Y140A Mutation：V1M, Y140A | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.22 Å R-free 0.237 |
| 1Y0C T-to-THigh Quaternary Transitions in Human Hemoglobin: alphaY140F deoxy low-salt Deposited 2004-11-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, Y140F Mutation：V1M, Y140F | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.30 Å R-free 0.256 |
| 1Y0D T-to-THigh Quaternary Transitions in Human Hemoglobin: desArg141alpha deoxy low-salt Deposited 2004-11-15 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–140（140 aa）
Fragment：Residues 1-140
Chain C
1–140（140 aa）
Fragment：Residues 1-140
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.10 Å R-free 0.242 |
| 1Y0T T-to-T(High) Quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (1 test set) Deposited 2004-11-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.14 Å R-free 0.238 |
| 1Y0W T-to-THigh quaternary Transitions in Human Hemoglobin: betaV1M deoxy low-salt (10 test sets) Deposited 2004-11-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.14 Å R-free 0.192 |
| 1Y22 T-To-T(High) quaternary transitions in human hemoglobin: betaV33A deoxy low-salt (1 test set) Deposited 2004-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 mM POTASSIUM PHOSPHATE, 100 mM POTASSIUM CHLORIDE, 3 mM SODIUM DITHIONITE, 10 mg/ml Hb, pH 7.00, temperature 298K
|
Resolution 2.16 Å R-free 0.248 |
| 1Y2Z T-To-T(High) quaternary transitions in human hemoglobin: betaV34G deoxy low-salt (1 test set) Deposited 2004-11-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298.0K
|
Resolution 2.07 Å R-free 0.240 |
| 1Y31 T-To-T(High) quaternary transitions in human hemoglobin: betaY35A deoxy low-salt (1 test set) Deposited 2004-11-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298.0K
|
Resolution 2.13 Å R-free 0.251 |
| 1Y35 T-To-T(High) quaternary transitions in human hemoglobin: betaY35F deoxy low-salt (1 test set) Deposited 2004-11-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.12 Å R-free 0.244 |
| 1Y45 T-To-T(high) quaternary transitions in human hemoglobin: betaP36A deoxy low-salt (10 test sets) Deposited 2004-11-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.00 Å R-free 0.209 |
| 1Y46 T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y deoxy low-salt (10 test sets) Deposited 2004-11-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.22 Å R-free 0.243 |
| 1Y4B T-To-T(High) quaternary transitions in human hemoglobin: betaW37H deoxy low-salt (10 test sets) Deposited 2004-11-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.10 Å R-free 0.238 |
| 1Y4F T-To-T(High) quaternary transitions in human hemoglobin: betaW37A deoxy low-salt (10 test sets) Deposited 2004-11-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.00 Å R-free 0.216 |
| 1Y4G T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets) Deposited 2004-11-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.91 Å R-free 0.235 |
| 1Y4P T-To-T(high) quaternary transitions in human hemoglobin: betaW37E deoxy low-salt (10 test sets) Deposited 2004-12-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.98 Å R-free 0.231 |
| 1Y4Q T-To-T(High) quaternary transitions in human hemoglobin: betaF42A deoxy low-salt (1 test set) Deposited 2004-12-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.11 Å R-free 0.245 |
| 1Y4R T-To-T(High) quaternary transitions in human hemoglobin: betaF45A deoxy low-salt (1 test set) Deposited 2004-12-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.22 Å R-free 0.246 |
| 1Y4V T-To-T(High) quaternary transitions in human hemoglobin: betaC93A deoxy low-salt (1 test set) Deposited 2004-12-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.84 Å R-free 0.230 |
| 1Y5F T-To-T(High) quaternary transitions in human hemoglobin: betaL96A deoxy low-salt (1 test set) Deposited 2004-12-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.14 Å R-free 0.243 |
| 1Y5J T-To-T(High) quaternary transitions in human hemoglobin: betaH97A deoxy low-salt (1 test set) Deposited 2004-12-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.03 Å R-free 0.245 |
| 1Y5K T-To-T(High) quaternary transitions in human hemoglobin: betaD99A deoxy low-salt (10 test sets) Deposited 2004-12-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.20 Å R-free 0.227 |
| 1Y7C T-To-T(High) quaternary transitions in human hemoglobin: betaP100A deoxy low-salt (1 test set) Deposited 2004-12-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.10 Å R-free 0.284 |
| 1Y7D T-To-T(High) quaternary transitions in human hemoglobin: betaP100G deoxy low-salt (1 test set) Deposited 2004-12-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.90 Å R-free 0.252 |
| 1Y7G T-To-T(high) quaternary transitions in human hemoglobin: betaN102A deoxy low-salt (1 test set) Deposited 2004-12-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 2.10 Å R-free 0.264 |
| 1Y7Z T-To-T(High) quaternary transitions in human hemoglobin: betaN108A deoxy low-salt (1 test set) Deposited 2004-12-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.98 Å R-free 0.233 |
| 1Y83 T-To-T(High) quaternary transitions in human hemoglobin: betaY145G deoxy low-salt (1 test set) Deposited 2004-12-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.0, batch, temperature 298K
|
Resolution 1.90 Å R-free 0.248 |
| 1Y85 T-To-T(High) quaternary transitions in human hemoglobin: desHIS146beta deoxy low-salt Deposited 2004-12-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 mM potassium phosphate, 100 mM potassium chloride, 3 mM sodium dithionite, 10 mg/ml Hb, pH 7.00, batch, temperature 298.0K
|
Resolution 2.13 Å R-free 0.237 |
| 1Y8W T-To-T(High) quaternary transitions in human hemoglobin: alphaR92A oxy (2mM IHP, 20% PEG) (10 test sets) Deposited 2004-12-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, R92A Mutation：V1M, R92A | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2.
EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 2.90 Å R-free 0.267 |
| 1YDZ T-To-T(High) quaternary transitions in human hemoglobin: alphaY140F oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Mutation：V1M, Y140F Mutation：V1M, Y140F | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2.
EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 3.30 Å R-free 0.307 |
| 1YE0 T-To-T(High) quaternary transitions in human hemoglobin: betaV33A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2.
EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 2.50 Å R-free 0.264 |
| 1YE1 T-To-T(High) quaternary transitions in human hemoglobin: betaY35A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 4.50 Å R-free 0.343 |
| 1YE2 T-To-T(High) quaternary transitions in human hemoglobin: betaY35F oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2004-12-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 1.80 Å R-free 0.212 |
| 1YEN T-To-T(High) quaternary transitions in human hemoglobin: betaP36A oxy (2MM IHP, 20% PEG) (10 test sets) Deposited 2004-12-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM
PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE,
10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2.
EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED
(UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING
20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM
POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL
WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS
COLLECTED AT 169K.
|
Resolution 2.80 Å R-free 0.267 |
| 1YEO T-To-T(High) quaternary transitions in human hemoglobin: betaW37A OXY (10 test sets) Deposited 2004-12-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM
PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE,
10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2.
EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED
(UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING
13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM
POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K
AND DATA WAS COLLECTED AT 298K.
|
Resolution 2.22 Å R-free 0.228 |
| 1YEQ T-To-T(High) quaternary transitions in human hemoglobin: betaW37Y OXY (10 test sets) Deposited 2004-12-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
|
Resolution 2.75 Å R-free 0.274 |
| 1YEU T-To-T(High) quaternary transitions in human hemoglobin: betaW37G OXY (10 test sets) Deposited 2004-12-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
|
Resolution 2.12 Å R-free 0.254 |
| 1YEV T-To-T(High) quaternary transitions in human hemoglobin: betaW37E OXY (10 test sets) Deposited 2004-12-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
|
Resolution 2.11 Å R-free 0.242 |
| 1YFF STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL Deposited 2004-12-31 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；PEG 4000, SODIUM PHOSPHATE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.40 Å R-free 0.250 |
| 1YFF STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN C (BETA E6K): TWO QUATERNARY STATES (R2 and R3) IN ONE CRYSTAL Deposited 2004-12-31 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；298 K；PEG 4000, SODIUM PHOSPHATE, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.40 Å R-free 0.250 |
| 1YG5 T-To-T(High) quaternary transitions in human hemoglobin: betaW37H OXY (2MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 2.70 Å R-free 0.273 |
| 1YGD T-To-T(High) quaternary transitions in human hemoglobin: betaW37E alpha zinc beta oxy (10 TEST SETS) Deposited 2005-01-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | ZNH PROTOPORPHYRIN IX CONTAINING ZN × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 13% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE. THE CRYSTAL WAS THEN EXPOSED TO AIR AT 298K AND DATA WAS COLLECTED AT 298K.
|
Resolution 2.73 Å R-free 0.266 |
| 1YGF T-to-T(high) quaternary transitions in human hemoglobin: betaH97A oxy (2MM IHP, 20% PEG) (1 test set) Deposited 2005-01-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 2.70 Å R-free 0.270 |
| 1YH9 T-to-T(High) quaternary transitions in human hemoglobin: HbA OXY (2MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 2.2 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 2.20 Å R-free 0.236 |
| 1YHE T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (5.0MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, PH 7.0, BATCH, TEMPERATURE 298K, 1 ATM N2. EXPOSING DEOXY CRYSTAL TO LIGAND: A DEOXY CRYSTAL WAS SOAKED (UNDER 1 ATM NITROGEN) IN SUBSTITUTE MOTHER LIQUOR CONTAINING 20% PEG 6000, 10 MM POTASSIUM PHOSPHATE (PH 7.0), 100 MM POTASSIUM CHLORIDE, AND 5.0 MM IHP. THE IHP-STABILIZED CRYSTAL WAS THEN EXPOSED TO 1 ATM OF OXYGEN AT 177K AND DATA WAS COLLECTED AT 169K.
|
Resolution 2.10 Å R-free 0.208 |
| 1YHR T-To-T(High) quaternary transitions in human hemoglobin: HbA OXY (10.0MM IHP, 20% PEG) (10 test sets) Deposited 2005-01-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.0, batch, temperature 298.0K
|
Resolution 2.60 Å R-free 0.270 |
| 1YIE T-to-thigh quaternary transitions in human hemoglobin: betaW37A oxy (2.2MM IHP, 13% PEG) (1 test set) Deposited 2005-01-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.00, batch, temperature 298.0K
|
Resolution 2.40 Å R-free 0.273 |
| 1YIH T-to-T(High) quaternary transitions in human hemoglobin: betaP100A oxy (2.2MM IHP, 20% PEG) (1 test set) Deposited 2005-01-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 7；298 K；10% PEG 6000, 10 MM POTASSIUM PHOSPHATE, 100 MM POTASSIUM CHLORIDE, 3 MM SODIUM DITHIONITE, 10 MG/ML DEOXYHB, 1 ATM N2, pH 7.0, batch, temperature 298.0K
|
Resolution 2.00 Å R-free 0.247 |
| 1YVQ The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5) Deposited 2005-02-16 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；290 K；0.1M HEPES, pH 7.5; 10% isopropanol, 20% PEG4000, VAPOR DIFFUSION, SITTING DROP, temperature 290K
|
Resolution 1.80 Å R-free 0.230 |
| 1YVT The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35) Deposited 2005-02-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.35；289 K；1.65M potassium phosphate, 0.1M HEPES, ph 7.35, Batch Method, temperature 289K
|
Resolution 1.80 Å R-free 0.236 |
| 1YZI A novel quaternary structure of human carbonmonoxy hemoglobin Deposited 2005-02-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 7.1；298 K；sodium/potassium phosphate, toluene, pH 7.1, SMALL TUBES, temperature 298K
|
Resolution 2.07 Å R-free 0.257 |
| 1Z8U Crystal structure of oxidized alpha hemoglobin bound to AHSP Deposited 2005-03-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG-2000 monomethyl ether, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.252 |
| 1Z8U Crystal structure of oxidized alpha hemoglobin bound to AHSP Deposited 2005-03-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG-2000 monomethyl ether, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.252 |
| 1Z8U Crystal structure of oxidized alpha hemoglobin bound to AHSP Deposited 2005-03-31 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
1–141（141 aa）
Chain D
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；MES, PEG-2000 monomethyl ether, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.252 |
| 28OD Crystal structure of C35 bound to Hem Deposited 2026-02-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 4 A1ITR 4-[2-[[5-(1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]benzoic acid × 2 DMS DIMETHYL SULFOXIDE × 10 CMO CARBON MONOXIDE × 4 ACT ACETATE ION × 3 SO4 SULFATE ION × 20 PGE TRIETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；3.0 M Ammonium sulfate; 1% (wv) MPD
|
Resolution 1.73 Å R-free 0.200 |
| 2D5Z Crystal structure of T-state human hemoglobin complexed with three L35 molecules Deposited 2005-11-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 L35 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH；pH 5.8；293 K；18% PEG 6000, 100mM Na-Cacodylate, 0.1mM L35, pH 5.8, BATCH, temperature 293K
|
Resolution 1.45 Å R-free 0.215 |
| 2D60 Crystal structure of deoxy human hemoglobin complexed with two L35 molecules Deposited 2005-11-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 L35 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH；pH 6.5；293 K；2.5M Ammonium sulfate, Ammonium phosphate, 0.1mM L35, pH 6.5, BATCH, temperature 293K
|
Resolution 1.70 Å R-free 0.240 |
| 2DN1 1.25A resolution crystal structure of human hemoglobin in the oxy form Deposited 2006-04-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 MBN TOLUENE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
Batch；pH 6.7；277 K；sodium/potassium phosphate, glycerol, pH 6.7, Batch, temperature 277K
|
Resolution 1.25 Å |
| 2DN2 1.25A resolution crystal structure of human hemoglobin in the deoxy form Deposited 2006-04-25 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
Batch；pH 6.5；293 K；Ammonium sulfate, Ammonium phosphate, pH 6.5, Batch, temperature 293K
|
Resolution 1.25 Å |
| 2DN3 1.25A resolution crystal structure of human hemoglobin in the carbonmonoxy form Deposited 2006-04-25 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH；pH 6.7；293 K；sodium/potassium phosphate, glycerol, pH 6.7, BATCH, temperature 293K
|
Resolution 1.25 Å |
| 2DXM Neutron Structure Analysis of Deoxy Human Hemoglobin Deposited 2006-08-28 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
NEUTRON DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；D2O, MICRODIALYSIS
|
Resolution 2.10 Å R-free 0.260 |
| 2H35 Solution structure of Human normal adult hemoglobin Deposited 2006-05-22 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
SOLUTION NMR
NMR measurement conditions
pH 7；303 K；Ionic strength (raw mmCIF value) 100 mM；Pressure 1
NMR sample composition
alpha_subunit 1.0mM, Na phosphate 0.1M, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition
beta_subunit 1.0mM, Na phosphate 0.1M, 90% H2O, 10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2HBC HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ENC ETHYL ISOCYANIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.10 Å |
| 2HBD HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MNC METHYL ISOCYANIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å |
| 2HBE HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NBN N-BUTYL ISOCYANIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 2HBF HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES Deposited 1994-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NPN N-PROPYL ISOCYANIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å |
| 2HBS THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S Deposited 1997-05-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4；HBS WAS SUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 120 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K, crystallized in anaerobic chamber
|
Resolution 2.05 Å R-free 0.215 |
| 2HBS THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S Deposited 1997-05-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–141（141 aa）
Chain G
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4；HBS WAS SUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 120 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K, crystallized in anaerobic chamber
|
Resolution 2.05 Å R-free 0.215 |
| 2HCO THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION Deposited 1979-08-07 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.70 Å |
| 2HHE OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN Deposited 1994-09-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.20 Å |
| 2M6Z Refined solution structure of Human Adult Hemoglobin in the Carbonmonoxy Form Deposited 2013-04-15 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
SOLUTION NMR
NMR measurement conditions
pH 7；308 K
NMR sample composition
1.2 mM [U-13C; U-15N] HbCO A-1, 1.0 mM [U-13C; U-15N] HbCO A-2, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2W6V Structure of Human deoxy Hemoglobin A in complex with Xenon Deposited 2008-12-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：CHAIN ALPHA, RESIDUES 2-142
Chain C
2–142（141 aa）
Fragment：CHAIN ALPHA, RESIDUES 2-142
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 3 SO4 SULFATE ION × 5 XE XENON × 10 PO4 PHOSPHATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；3.2M (NH4)2SO4, 0.1M (NH4)H2PO4, 0.3M (NH4)2HPO4, PH 6.5, 0.2% DITHIONITE.
|
Resolution 1.80 Å R-free 0.216 |
| 2W72 DEOXYGENATED STRUCTURE OF A DISTAL SITE HEMOGLOBIN MUTANT PLUS XE Deposited 2008-12-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：CHAIN ALPHA, RESIDUES 2-142
Chain C
2–142（141 aa）
Fragment：CHAIN ALPHA, RESIDUES 2-142
|
Mutation：YES Mutation：YES | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 8 XE XENON × 15 K POTASSIUM ION × 3 PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；3.2M AMMONIUM SULPHATE 0.1M AMMONIUM PHOSPHATE 0.3M K PHOSPHATE PH 6.7
|
Resolution 1.07 Å R-free 0.153 |
| 2YRS Human hemoglobin D Los Angeles: crystal structure Deposited 2007-04-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.6；293 K；pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.252 |
| 2YRS Human hemoglobin D Los Angeles: crystal structure Deposited 2007-04-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Chain M
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.6；293 K；pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.252 |
| 3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | FRU beta-D-fructofuranose × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 GLC alpha-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.331 |
| 3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | FRU beta-D-fructofuranose × 1 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.331 |
| 3B75 Crystal Structure of Glycated Human Haemoglobin Deposited 2007-10-30 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain S
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 GLC alpha-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.7；277 K；PEG 4000, pH 6.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.331 |
| 3D17 A triply ligated crystal structure of relaxed state human hemoglobin Deposited 2008-05-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 1 CMO CARBON MONOXIDE × 3 PO4 PHOSPHATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.4；298 K；NaPhosph, KPhosph, Toluene, pH 6.4, liquid diffusion, temperature 298K
|
Resolution 2.80 Å R-free 0.297 |
| 3D7O Human hemoglobin, nitrogen dioxide anion modified Deposited 2008-05-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | NO2 NITRITE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；295 K；Sodium phosphate, Potassium phosphate, Toluene, Hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
|
Resolution 1.80 Å R-free 0.237 |
| 3DUT The high salt (phosphate) crystal structure of deoxy hemoglobin E (GLU26LYS) at physiological pH (pH 7.35) Deposited 2008-07-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.35；294 K；1.65 M potassium phosphate, 0.05 M Bis-Tris, pH 7.35, VAPOR DIFFUSION, SITTING DROP, temperature 294K
|
Resolution 1.55 Å R-free 0.277 |
| 3HXN The structure of human carbonmonoxyhemoglobin complex to IHP at 2.0 angstrons resolution. Deposited 2009-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 IHP INOSITOL HEXAKISPHOSPHATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；295 K；CARBONMONOXYHEMOGLOBIN:IHP 1:1, CRYSTALLIZED IN 27% PEG 3350 BUBBLED IN CO- , pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.00 Å R-free 0.283 |
| 3IA3 A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin Deposited 2009-07-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES, pH 6.5, 4% acetonitrile and 14.5% (w/v) PEG3000, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.20 Å R-free 0.293 |
| 3IA3 A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin Deposited 2009-07-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M MES, pH 6.5, 4% acetonitrile and 14.5% (w/v) PEG3000, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.20 Å R-free 0.293 |
| 3IC0 Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-298 Deposited 2009-07-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 B77 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；3.2 - 3.6 M Sulfate/phosphate precipitant, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.80 Å R-free 0.230 |
| 3IC2 Crystal Structure of liganded hemoglobin in complex with a potent antisickling agent, INN-266 Deposited 2009-07-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 B78 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；3.2 - 3.6 M Sulfate/phosphate precipitant, pH 6.5, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.40 Å R-free 0.246 |
| 3KMF Room Temperature Time-of-Flight Neutron Diffraction Study of Deoxy Human Normal Adult Hemoglobin Deposited 2009-11-10 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain E
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
NEUTRON DIFFRACTION
X-ray crystallization conditions
batch；pH 6.7；293 K；D2O, BATCH, ammonium sulfate, pH 6.7, batch, temperature 293K
|
Resolution 2.00 Å R-free 0.300 |
| 3NL7 Human Hemoglobin A mutant beta H63W carbonmonoxy-form Deposited 2010-06-21 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.7；293 K；Protein Solution (20mg/ml protein in 0.01 M phosphate pH 7.0) mixed with mother liquor (3.4 M Na/K phosphate, pH6.7) for final concentrations of 2.3 M Na/K phosphate, SMALL TUBES, temperature 293K
|
Resolution 1.80 Å R-free 0.233 |
| 3NMM Human Hemoglobin A mutant alpha H58W deoxy-form Deposited 2010-06-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Mutation：H59W Mutation：H59W | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
Batch Method；pH 6.5；293 K；20 ul Protein Solution (60mg/ml protein in 0.01 M ammonium phosphate pH 7.0) mixed with
100 ul mother liquor (0.5 ml 2M monobasic ammonium phosphate + 1.5 ml 2 M dibasic ammonium phosphate + 8 ml 4 M ammonium sulfate) for final concentrations of 2.4-2.6 M Ammonium phosphate/sulfate, Batch Method, temperature 293K
|
Resolution 1.60 Å R-free 0.198 |
| 3ODQ Structure of a Crystal Form of Human Methemoglobin Indicative of Fiber Formation Deposited 2010-08-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；295 K；15-30% PEG, pH 4.5-5.5, 0.2 M salt of several varieties, VAPOR DIFFUSION, SITTING DROP, temperature 295K
|
Resolution 3.10 Å R-free 0.325 |
| 3ONZ Human tetrameric hemoglobin: proximal nitrite ligand at beta Deposited 2010-08-30 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：Hemoglobin Chain A
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NO2 NITRITE ION × 4 MBN TOLUENE × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 7.1；295 K；sodium phospahte, potassium phosphate, toluene, nitrite, hemoglobin, pH 7.1, LIQUID DIFFUSION, temperature 295K
|
Resolution 2.09 Å R-free 0.280 |
| 3OO4 R-state human hemoglobin: nitriheme modified at alpha Deposited 2010-08-30 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | NTE [3,3'-{7-ethenyl-3,8,13,17-tetramethyl-12-[(E)-2-nitroethenyl]porphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~}dipro panoato(2-)]iron × 2 NO2 NITRITE ION × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, nitrite, toluene, hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
|
Resolution 1.90 Å R-free 0.263 |
| 3OO5 R-state human hemoglobin: nitriheme modified Deposited 2010-08-30 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | NTE [3,3'-{7-ethenyl-3,8,13,17-tetramethyl-12-[(E)-2-nitroethenyl]porphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~}dipro panoato(2-)]iron × 4 NO2 NITRITE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；295 K；sodium phosphate, potassium phosphate, nitrite, toluene, human hemoglobin, LIQUID DIFFUSION, temperature 295K
|
Resolution 2.10 Å R-free 0.287 |
| 3OVU Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2010-09-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M sodium acetate, 20%(w/v) PEG 3350, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.83 Å R-free 0.280 |
| 3P5Q Ferric R-state human aquomethemoglobin Deposited 2010-10-10 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, hemoglobin, pH 6.8, LIQUID DIFFUSION, temperature 295K
|
Resolution 2.00 Å R-free 0.267 |
| 3QJB Human Hemoglobin A Mutant Alpha H58L Carbonmonoxy-Form Deposited 2011-01-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Mutation：H58L | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.7；293 K；2.3 M Na/K phosphate, pH 6.7, SMALL TUBES, temperature 293K
|
Resolution 1.80 Å R-free 0.205 |
| 3QJC Human Hemoglobin A Mutant Beta H63L Carbonmonoxy-Form Deposited 2011-01-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.7；293 K；2.3 M Na/K phosphate, pH 6.7, SMALL TUBES, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 3QJD Human Hemoglobin A Mutant Alpha H58L Deoxy-Form Deposited 2011-01-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Mutation：H58L Mutation：H58L | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.5；293 K；2.4-2.6 M ammonium phosphate/sulfate, pH 6.5, SMALL TUBES, temperature 293K
|
Resolution 1.56 Å R-free 0.191 |
| 3QJE Human Hemoglobin A Mutant Beta H63L Deoxy-Form Deposited 2011-01-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6.5；293 K；2.4-2.6 M ammonium phosphate/sulfate, pH 6.5, SMALL TUBES, temperature 293K
|
Resolution 1.80 Å R-free 0.243 |
| 3R5I Crystal structure of liganded Hemoglobin complexed with a potent Antisickling agent, INN-312 Deposited 2011-03-18 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3R5 5-methoxy-2-(pyridin-3-ylmethoxy)benzaldehyde × 3 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.4；298 K；3.2 M Na+/K+ phosphate, pH 6.4, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.20 Å R-free 0.268 |
| 3S48 Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-05-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain D
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.2M sodium sulphate, 0.1M Bis Tris propane, 16%(w/v) PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.05 Å R-free 0.268 |
| 3S48 Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-05-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.2M sodium sulphate, 0.1M Bis Tris propane, 16%(w/v) PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.05 Å R-free 0.268 |
| 3S65 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R2 quaternary structures Deposited 2011-05-25 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.6；293 K；11% (w/v) polyethylene glycol 3350, 50mM HEPES buffer, 10% (v/v) glycerol, pH 7.6, Batch, temperature 293K
|
Resolution 1.80 Å R-free 0.305 |
| 3S66 Structures and oxygen affinities of crystalline human hemoglobin C (beta6 Lys) in the R quaternary structures Deposited 2011-05-25 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.2；293 K；1.65M phosphate buffer (0.528M NaH2PO4, 1.122M K2HPO4, pH 7.2), 10% (v/v) glycerol, 0.1% (w/v) D,L-homocysteine, Batch, temperature 293K
|
Resolution 1.40 Å R-free 0.233 |
| 3SZK Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-07-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M potassium thiocyanate, 0.1M Tris-bis propane, 20% PEG 3350 , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.01 Å R-free 0.275 |
| 3SZK Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus Deposited 2011-07-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M potassium thiocyanate, 0.1M Tris-bis propane, 20% PEG 3350 , pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.01 Å R-free 0.275 |
| 3WCP Deoxyhemoglobin SH-drug complex Deposited 2013-05-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 DG2 (2R)-2,3-diphosphoglyceric acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
batch；pH 6.6；298 K；0.2M sodium acetate trihydrate, 0.1M sodium cacodylate trihydrate, 30% PEG8000, pH 6.6, batch, temperature 298K
|
Resolution 1.94 Å R-free 0.263 |
| 3WHM Structure of Hemoglobin Complex with 18-crown-6 Deposited 2013-08-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain E
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 OXY OXYGEN MOLECULE × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；30% (w/v) PEG 3350, 0.2M Lithium sulfate, 0.1M Tris pH 8.0, 25mM 18-crown-6, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 1.85 Å R-free 0.253 |
| 4FC3 Crystal Structure of Human Methaemoglobin Complexed with the Second NEAT Domain of IsdH from Staphylococcus aureus Deposited 2012-05-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.2M Sodium formate, 0.1M bis-tris propane, 20% PEG3350, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.26 Å R-free 0.256 |
| 4HHB THE CRYSTAL STRUCTURE OF HUMAN DEOXYHAEMOGLOBIN AT 1.74 ANGSTROMS RESOLUTION Deposited 1984-03-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.74 Å |
| 4IJ2 Human methemoglobin in complex with the second and third NEAT domains of IsdH from Staphylococcus aureus Deposited 2012-12-21 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；294 K；0.2M diammonium citrate, 13%(w/v) PEG3350, 0.7% 1-butanol, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 4.24 Å R-free 0.310 |
| 4L7Y Deoxygenated Hb in complex with the allosteric effectors, IRL2500 and 2,3-DPG Deposited 2013-06-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | MH0 Mesoheme × 4 IRL (2R)-2-({(2S)-3-(biphenyl-4-yl)-2-[(3,5-dimethylbenzoyl)(methyl)amino]propanoyl}amino)-3-(1H-indol-3-yl)propanoic acid (non-preferred name) × 1 DG2 (2R)-2,3-diphosphoglyceric acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.6；297 K；0.2M sodium acetate trihydrate, 0.1M sodium cacodylate trihydrate,30% PEG8000, pH 6.6, LIQUID DIFFUSION, temperature 297K
|
Resolution 1.80 Å R-free 0.228 |
| 4M4A Human Hemoglobin Nitromethane Modified Deposited 2013-08-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NSM NITROSOMETHANE × 4 GOL GLYCEROL × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, pH 6.8, LIQUID DIFFUSION, temperature 295K
|
Resolution 2.05 Å R-free 0.280 |
| 4M4B Human Hemoglobin Nitroethane Modified Deposited 2013-08-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 2 NOE NITROSOETHANE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；295 K；sodium phosphate, potassium phosphate, toluene, pH 6.8, LIQUID DIFFUSION, temperature 295K
|
Resolution 2.00 Å R-free 0.270 |
| 4MQC Carbonmonoxy Structure of Hemoglobin Evans alphaV62Mbetawt Deposited 2013-09-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Mutation：V67M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, batch method, pH 6.7, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.20 Å R-free 0.250 |
| 4MQG Structure of Carbonmonoxy Adult Hemoglobin Bristol-Alesha alphawtbetaV67M Deposited 2013-09-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Mutation：V67M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；298 K；Protein crystallized from 1.9M Sodium/Potassium Phosphate, Batch method, pH 7.0, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.68 Å R-free 0.243 |
| 4MQH Structure of Aquomet Hemoglobin Evans alphaV62Mbetawt Deposited 2013-09-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–140（139 aa）
|
Mutation：V67M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, pH 6.7, Batch method, temperature 298K, LIQUID DIFFUSION
|
Resolution 2.50 Å R-free 0.250 |
| 4MQI Structure of Aquomet Hemoglobin Bristol-Alesha alphawtbetaV67M Deposited 2013-09-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
|
Mutation：V67M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.7；298 K；Protein crystallized from 2.2M Sodium/Potassium Phosphate, pH 6.7, Batch method, temperature 298K, LIQUID DIFFUSION
|
Resolution 1.92 Å R-free 0.239 |
| 4MQJ Structure of Wild-type Fetal Human Hemoglobin HbF Deposited 2013-09-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 7；298 K；Protein crystallized from 1.9M Sodium/Potassium Phosphate, pH 7.0, Batch method, temperature 298K, LIQUID DIFFUSION
|
Resolution 1.80 Å R-free 0.215 |
| 4MQJ Structure of Wild-type Fetal Human Hemoglobin HbF Deposited 2013-09-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
2–142（141 aa）
Chain E
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 2 OXY OXYGEN MOLECULE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 7；298 K；Protein crystallized from 1.9M Sodium/Potassium Phosphate, pH 7.0, Batch method, temperature 298K, LIQUID DIFFUSION
|
Resolution 1.80 Å R-free 0.215 |
| 4MQK Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M Deposited 2013-09-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain E
2–142（141 aa）
|
Mutation：V67M Mutation：V67M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 7；298 K；1.9M Sodium/Potassium Phosphate, Batch method, pH 7, EVAPORATION, temperature 298K
|
Resolution 2.24 Å R-free 0.232 |
| 4MQK Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M Deposited 2013-09-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain C
2–142（141 aa）
Chain G
2–142（141 aa）
|
Mutation：V67M Mutation：V67M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 7；298 K；1.9M Sodium/Potassium Phosphate, Batch method, pH 7, EVAPORATION, temperature 298K
|
Resolution 2.24 Å R-free 0.232 |
| 4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：UNP residues 2-142
Chain C
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
|
Resolution 2.75 Å R-free 0.286 |
| 4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Fragment：UNP residues 2-142
Chain G
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
|
Resolution 2.75 Å R-free 0.286 |
| 4N7N Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of full-liganded human haemoglobin with phosphate at 2.75 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Fragment：UNP residues 2-142
Chain K
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 6.8；298 K；18% PEG3350, 5% glycerol , pH 6.8, microbatch under paraffin oil, temperature 298K
|
Resolution 2.75 Å R-free 0.286 |
| 4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：UNP residues 2-142
Chain C
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)],
17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
|
Resolution 2.50 Å R-free 0.292 |
| 4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Fragment：UNP residues 2-142
Chain G
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)],
17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
|
Resolution 2.50 Å R-free 0.292 |
| 4N7O Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin with phosphate at 2.5 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Fragment：UNP residues 2-142
Chain K
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 6.8；298 K；CO-saturated 1.0% XL[alpha(Fe-Co)beta(Ni)][alpha(Ni)beta(Fe-Co)],
17% PEG3350, 10mM Potassium phosphate pH6.8 , microbatch under paraffin oil, temperature 298K
|
Resolution 2.50 Å R-free 0.292 |
| 4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：UNP residues 2-142
Chain C
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
|
Resolution 2.81 Å R-free 0.287 |
| 4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Fragment：UNP residues 2-142
Chain G
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
|
Resolution 2.81 Å R-free 0.287 |
| 4N7P Capturing the haemoglobin allosteric transition in a single crystal form; Crystal structure of half-liganded human haemoglobin without phosphate at 2.8 A resolution. Deposited 2013-10-16 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Fragment：UNP residues 2-142
Chain K
2–142（141 aa）
Fragment：UNP residues 2-142
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
microbatch under paraffin oil；pH 7.6；298 K；pH 7.6, microbatch under paraffin oil, temperature 298K
|
Resolution 2.81 Å R-free 0.287 |
| 4N8T Human hemoglobin nitric oxide adduct Deposited 2013-10-18 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 6 NO2 NITRITE ION × 2 NO NITRIC OXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；295 K；SOLDIUM PHOSPHATE, POTASSIUM PHOSPHATE, TOLUENE, HUMAN HEMOGLOBIN, pH 6.8, LIQUID DIFFUSION, temperature 295K
|
Resolution 1.90 Å R-free 0.252 |
| 4NI0 Quaternary R3 CO-liganded hemoglobin structure in complex with a thiol containing compound Deposited 2013-11-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2P3 5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione × 8 MBN TOLUENE × 6 PO4 PHOSPHATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；298 K；20-30mg/mL protein, 3.0-3.4 M Sodium/potassium phosphate, pH 6.8, LIQUID DIFFUSION, temperature 298K
|
Resolution 2.15 Å R-free 0.259 |
| 4NI1 Quaternary R CO-liganded hemoglobin structure in complex with a thiol containing compound Deposited 2013-11-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 2JX 5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione × 8 MBN TOLUENE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.4；298 K；20-30mg/mL protein, 3.0-3.4 M sodium/potassium phosphate, pH 6.4, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.90 Å R-free 0.259 |
| 4ROL Deoxyhemoglobin in complex with imidazolylacryloyl derivatives Deposited 2014-10-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3U7 4-{2,3-dichloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；298 K；3.2 M sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.70 Å R-free 0.205 |
| 4ROM Deoxyhemoglobin in complex with imidazolylacryloyl derivatives Deposited 2014-10-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 3U8 4-{2-chloro-4-[3-(1H-imidazol-2-yl)propanoyl]phenoxy}butanoic acid × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.8；298 K；3.2 M sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION, temperature 298K
|
Resolution 1.90 Å R-free 0.248 |
| 4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: Decameric |
Chain A
2–142（141 aa）
Chain F
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
|
Resolution 3.10 Å R-free 0.271 |
| 4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Other combination Heteromer；Protein × 10 PDB declaration: Decameric |
Chain K
2–142（141 aa）
Chain P
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
|
Resolution 3.10 Å R-free 0.271 |
| 4WJG Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin Deposited 2014-09-30 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Other combination Heteromer；Protein × 10 PDB declaration: Decameric |
Chain U
2–142（141 aa）
Chain Z
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；15% Polyethylene glycol (PEG) 1500, 0.1M Bis-Tris
|
Resolution 3.10 Å R-free 0.271 |
| 4X0L Human haptoglobin-haemoglobin complex Deposited 2014-11-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 CAC CACODYLATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M NaCl, 0.1 M sodium cacodylate pH 6.5 and 2 M ammonium sulphate
|
Resolution 2.05 Å R-free 0.224 |
| 4XS0 Human methemoglobin in complex with the second and third NEAT domains of IsdH(F365Y/A369F/Y642A) from Staphylococcus aureus Deposited 2015-01-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CL CHLORIDE ION × 3 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；0.2 M K/Na tartrate, 0.1 M tri-sodium citrate pH 5.6, 2 M ammonium sulfate. Cryoprotected in 20% glycerol.
|
Resolution 2.55 Å R-free 0.287 |
| 5E29 Crystal Structure of Deoxygenated Hemoglobin in Complex with an Allosteric Effector and Nitric Oxide Deposited 2015-09-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | NO NITRIC OXIDE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 5JN 2-(nitrooxy)ethyl 2-(4-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}phenoxy)-2-methylpropanoate × 1 RQ3 2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID × 2 NO3 NITRATE ION × 2 CAC CACODYLATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；295 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5, 30% w/v PEG8000, anaerobic conditions
|
Resolution 1.85 Å R-free 0.253 |
| 5E6E Crystal Structure of Carbonmonoxy Sickle Hemoglobin in R-State Conformation Deposited 2015-10-09 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MBN TOLUENE × 4 PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.6；293 K；3.2 M phosphate
|
Resolution 1.76 Å R-free 0.243 |
| 5E83 CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT440, CO-CRYSTALLIZATION EXPERIMENT Deposited 2015-10-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 5L7 2-methyl-3-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)phenol × 1 GOL GLYCEROL × 3 UNL UNKNOWN LIGAND × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.4；294 K；0.1M HEPES, 25% PEG4000, PH 7.4, 40 MM NACL
|
Resolution 1.80 Å R-free 0.207 |
| 5EE4 The crystal structure of HpuA from Kingella denitrificans in complex with human haemoglobin Deposited 2015-10-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain C
2–142（141 aa）
|
Not recorded | GOL GLYCEROL × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；277 K；100 mM Hepes, 18 % Peg 4,000, 10 % Isopropanol
|
Resolution 2.30 Å R-free 0.244 |
| 5EE4 The crystal structure of HpuA from Kingella denitrificans in complex with human haemoglobin Deposited 2015-10-22 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain E
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；277 K；100 mM Hepes, 18 % Peg 4,000, 10 % Isopropanol
|
Resolution 2.30 Å R-free 0.244 |
| 5HU6 Structure of the T. brucei haptoglobin-haemoglobin receptor bound to human haptolgobin-haemoglobin Deposited 2016-01-27 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；12.5% v/v MPD, 0.03 M NaBr, 0.03M NaI, 0.03M NaF, 0.1 M MES/imidazole pH 6.5, 12.5% w/v PEG 1000, 12.5% w/v PEG 3350
|
Resolution 2.90 Å R-free 0.226 |
| 5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 FRU beta-D-fructofuranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
|
Resolution 2.30 Å R-free 0.244 |
| 5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 FRU beta-D-fructofuranose × 2 GLC alpha-D-glucopyranose × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
|
Resolution 2.30 Å R-free 0.244 |
| 5HY8 Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes Deposited 2016-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain S
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；PEG 4000
|
Resolution 2.30 Å R-free 0.244 |
| 5JDO T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin Deposited 2016-04-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain C
2–142（141 aa）
Chain E
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；291 K；0.1 M sodium citrate pH 5, 8% w/v PEG 8000
|
Resolution 3.20 Å R-free 0.235 |
| 5KDQ Deoxyhemoglobin in Complex with an Aryloxyalkanoic acid Deposited 2016-06-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 PO4 PHOSPHATE ION × 2 KOH 3-[2-chloranyl-4-(1~{H}-imidazol-2-yl)phenoxy]propanoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；3.2 M Sulfate/phosphate precipitant, pH 6.8, LIQUID DIFFUSION
|
Resolution 2.15 Å R-free 0.257 |
| 5KSI Crystal structure of deoxygenated hemoglobin in complex with sphingosine phosphate and 2,3-Bisphosphoglycerate Deposited 2016-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 S1P (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate × 5 DG2 (2R)-2,3-diphosphoglyceric acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5 and 30% PEG 8000
|
Resolution 1.80 Å R-free 0.220 |
| 5KSJ Crystal structure of deoxygenated hemoglobin in complex with Sphingosine phosphate Deposited 2016-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 S1P (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.5；298 K；0.2 M sodium acetate trihydrate, 0.1 M sodium cacodylate trihydrate, pH 6.5 and 30% PEG 8000
|
Resolution 2.40 Å R-free 0.287 |
| 5NI1 CryoEM structure of haemoglobin at 3.2 A determined with the Volta phase plate Deposited 2017-03-22 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE-PROPANE
|
Resolution 3.20 Å |
| 5SW7 Structure of the Human Hemoglobin Mutant Hb Providence (A-Gly-C:V1M; B,D:V1M,K82D; Ferrous, carbonmonoxy bound) Deposited 2016-08-08 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Mutation：V1M | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.7；296 K；2.5M sodium/potassium phosphate
|
Resolution 1.85 Å R-free 0.222 |
| 5U3I CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT compound 31 Deposited 2016-12-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 7SJ 2-methoxy-5-({2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl}methoxy)pyridine-4-carbaldehyde × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；100 mM Hepes pH 7.4
20 mM NaCl
30 % PEG 3350
|
Resolution 1.95 Å R-free 0.253 |
| 5UCU STRUCTURAL AND MECHANISTIC INSIGHTS INTO HEMOGLOBIN-CATALYZED HYDROGEN SULFIDE OXIDATION AND THE FATE OF POLYSULFIDE PRODUCTS Deposited 2016-12-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 H2S HYDROSULFURIC ACID × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293.15 K；10% Toluene, 2.3 M K2HPO4/NH2PO4 pH, 7.2.
|
Resolution 1.80 Å R-free 0.222 |
| 5UFJ Crystal Structure of Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Complexed with GBT Compound 6 Deposited 2017-01-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 86M 5-[(imidazo[1,2-a]pyridin-8-yl)methoxy]-2-methoxypyridine-4-carbaldehyde × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；296 K；0.1 M Hepes pH 7.4, 40 mM NaCl, 29 % PEG3350
|
Resolution 2.05 Å R-free 0.254 |
| 5URC Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease Deposited 2017-02-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 8MV (5-formylfuran-2-yl)methyl acetate × 1 FUX 5-HYDROXYMETHYL-FURFURAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.4；298 K；25% PEG4000, 0.1 M Hepes, 40 mM Sodium Chloride
|
Resolution 1.85 Å R-free 0.223 |
| 5VMM Staphylococcus aureus IsdB bound to human hemoglobin Deposited 2017-04-27 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；0.1 M malonic acid pH 5.5, 2.2 M ammonium sulfate
|
Resolution 3.60 Å R-free 0.302 |
| 5WOG Human Hemoglobin immersed in Liquid Oxygen for 1 minute Deposited 2017-08-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–139（137 aa）
Chain B
3–139（137 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；277.15 K；1 mL of 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
|
Resolution 1.54 Å R-free 0.206 |
| 5WOH Human Hemoglobin Immersed in Liquid Oxygen for 20 seconds Deposited 2017-08-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–139（137 aa）
Chain C
3–139（137 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；277.15 K；1 mL of 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
|
Resolution 1.58 Å R-free 0.207 |
| 5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.70 Å R-free 0.306 |
| 5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.70 Å R-free 0.306 |
| 5X2R Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 10 mM phosphate pH 6.9. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Chain K
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.70 Å R-free 0.306 |
| 5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.39 Å R-free 0.288 |
| 5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.39 Å R-free 0.288 |
| 5X2S Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 6.5. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Chain K
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 PEM 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.39 Å R-free 0.288 |
| 5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.64 Å R-free 0.277 |
| 5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.64 Å R-free 0.277 |
| 5X2T Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 4 mM bezafibrate pH 7.2. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Chain K
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 PEM 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.64 Å R-free 0.277 |
| 5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.53 Å R-free 0.274 |
| 5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.53 Å R-free 0.274 |
| 5X2U Direct Observation of Conformational Population Shifts in Hemoglobin: Crystal Structure of Half-Liganded Hemoglobin after Adding 80 mM phosphate pH 6.7. Deposited 2017-02-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–142（141 aa）
Chain K
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 7.7；293 K；17%(w/v) PEG 3350, pH 7.7
|
Resolution 2.53 Å R-free 0.274 |
| 6BB5 Human Oxy-Hemoglobin Deposited 2017-10-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；277 K；1 mL 40 mg/mL hemoglobin + 2.65 M (final concentration) phosphate buffer, topped with 100 uL toluene
|
Resolution 2.28 Å R-free 0.242 |
| 6BNR Carbonmonoxy hemoglobin in complex with the antisickling agent 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde (INN310) Deposited 2017-11-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 E0J 2-[(4-methoxy-2-methylphenoxy)methyl]pyridine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.4；298 K；25% PEG 6000, 0.1M HEPES (pH 7.4)
|
Resolution 1.95 Å R-free 0.264 |
| 6BWP Crystal structure of Deoxy Hemoglobin in complex with beta Cys93 modifying agent, TD3 Deposited 2017-12-15 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 EBJ 1H-1,2,3-triazole-5-thiol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.6；293 K；3.4M Na Phosphate/NH4 Sulfate
|
Resolution 1.70 Å R-free 0.197 |
| 6BWU Crystal structure of carboxyhemoglobin in complex with beta Cys93 modifying agent, TD3 Deposited 2017-12-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 EBJ 1H-1,2,3-triazole-5-thiol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.6；293 K；3.2M Na/K Phosphate
|
Resolution 2.00 Å R-free 0.265 |
| 6DI4 Rational Modification of Vanillin Derivatives to Stereospecifically Destabilize Sickle Hemoglobin Polymer Formation Deposited 2018-05-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GJ1 {6-[(4-methoxy-2-methylphenoxy)methyl]pyridin-2-yl}methanol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.4；298 K；10-20% PEG6000, 100mM Hepes pH 7.4
|
Resolution 1.90 Å R-free 0.249 |
| 6HAL Human carbonmonoxy hemoglobin SFX dataset Deposited 2018-08-07 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–141（139 aa）
Chain C
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7；293 K；batch crystallization, using 1.6 M Na/K phosphate, neutal pH as precipitant
|
Resolution 2.20 Å R-free 0.211 |
| 6HBW Crystal structure of deoxy-human hemoglobin beta6 glu->trp Deposited 1998-09-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–141（141 aa）
Chain C
1–141（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；PROTEIN WAS RESUSPENDED IN 30 MM PHOSPHATE BUFFER, PH 7.0, DEOXYGENATED AND CONCENTRATED TO 160 MG/ML. PROTEIN WAS CRYSTALLIZED IN AN ANAEROBIC CHAMBER IN TUBE CONTAINING 10 UL PROTEIN SOLUTION, 5 UL CITRATE BUFFER (PH 4.0), AND 4UL OF 33% PEG 8K.
|
Resolution 2.00 Å R-free 0.264 |
| 6HK2 Crystal structure of ferric R-state human methemoglobin bound to maleimide-deferoxamine bifunctional chelator (DFO) Deposited 2018-09-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 1 SO4 SULFATE ION × 7 G7Z 3-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]-~{N}-methyl-propanamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 5.8；293 K；2.4 M (NH4)2SO4, 0.23 M (NH4)2HPO4, 0.07 M (NH4)H2PO4
|
Resolution 1.55 Å R-free 0.212 |
| 6KA9 Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；18%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.40 Å R-free 0.191 |
| 6KA9 Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；18%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.40 Å R-free 0.191 |
| 6KAE Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 8 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；18%w/v PEG3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.45 Å R-free 0.200 |
| 6KAE Crosslinked alpha(Fe-CO)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-21 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 8 HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；18%w/v PEG3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.45 Å R-free 0.200 |
| 6KAH Crosslinked alpha(Ni)-beta(Fe-CO) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.45 Å R-free 0.196 |
| 6KAH Crosslinked alpha(Ni)-beta(Fe-CO) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.45 Å R-free 0.196 |
| 6KAI Crosslinked alpha(Ni)-beta(Fe) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 CMO CARBON MONOXIDE × 7 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.45 Å R-free 0.202 |
| 6KAI Crosslinked alpha(Ni)-beta(Fe) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-06-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 2 CMO CARBON MONOXIDE × 8 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；20%w/v PEG 3350, 50 mM citrate-ammonium buffer, 150 mM dipotassium sulfate
|
Resolution 1.45 Å R-free 0.202 |
| 6KAO Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Dark Deposited 2019-06-23 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
|
Resolution 1.40 Å R-free 0.211 |
| 6KAP Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Light Deposited 2019-06-23 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
|
Resolution 1.45 Å R-free 0.211 |
| 6KAQ Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Dark Deposited 2019-06-24 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
|
Resolution 1.50 Å R-free 0.220 |
| 6KAR Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Light Deposited 2019-06-24 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
|
Resolution 1.60 Å R-free 0.226 |
| 6KAS Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Dark Deposited 2019-06-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
|
Resolution 1.65 Å R-free 0.202 |
| 6KAT Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Light Deposited 2019-06-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
|
Resolution 1.70 Å R-free 0.203 |
| 6KAU Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Dark Deposited 2019-06-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
|
Resolution 1.60 Å R-free 0.213 |
| 6KAV Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Light Deposited 2019-06-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 5.8；293 K；18%w/v PEG6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
|
Resolution 1.70 Å R-free 0.205 |
| 6L5V Carbonmonoxy human hemoglobin C in the R quaternary structure at 95 K: Light (2 min) Deposited 2019-10-24 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
|
Resolution 1.45 Å R-free 0.213 |
| 6L5W Carbonmonoxy human hemoglobin C in the R quaternary structure at 140 K: Light (2 min) Deposited 2019-10-24 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.2；293 K；0.528 M sodium dihydrogen phosphate, 1.122 M dipotassium hydrogen phosphate, 10%v/v glycerol
|
Resolution 1.50 Å R-free 0.215 |
| 6L5X Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 95 K: Light (2 min) Deposited 2019-10-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
|
Resolution 1.65 Å R-free 0.207 |
| 6L5Y Carbonmonoxy human hemoglobin A in the R2 quaternary structure at 140 K: Light (2 min) Deposited 2019-10-24 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 5.8；293 K；18%w/v PEG 6000, 100 mM sodium cacodylate-hydrochloride buffer, 10%v/v glycerol
|
Resolution 1.65 Å R-free 0.206 |
| 6LCW Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
|
Resolution 1.40 Å R-free 0.218 |
| 6LCW Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Dark Deposited 2019-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
|
Resolution 1.40 Å R-free 0.218 |
| 6LCX Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG 3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
|
Resolution 1.40 Å R-free 0.216 |
| 6LCX Crosslinked alpha(Ni)-beta(Ni) human hemoglobin A in the T quaternary structure at 95 K: Light Deposited 2019-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HNI PROTOPORPHYRIN IX CONTAINING NI(II) × 4 2FU BUT-2-ENEDIAL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
MICROBATCH；pH 6.6；293 K；1.0% (w/v) protein solution that contains 18% (w/v) PEG 3350, 0.15 M dipotassium sulfate, 50 mM citrate-ammonium buffer (pH 6.6)
|
Resolution 1.40 Å R-free 0.216 |
| 6NBC human methemoglobin state 1 determined using single-particle cryo-EM at 200 keV Deposited 2018-12-06 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Sample was manually blotted for 4-5 seconds using Whatman No. 1 filter paper immediately prior to plunge-freezing.
|
Resolution 2.80 Å |
| 6NBD Human methemoglobin state 2 determined using single-particle cryo-EM at 200 keV Deposited 2018-12-06 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；Sample was manually blotted for 4-5 seconds using Whatman No. 1 filter paper immediately prior to plunge-freezing.
|
Resolution 3.20 Å |
| 6NQ5 human (alpha met/beta hemichrome) hemoglobin with S-nitrosation at beta-Cys93 Deposited 2019-01-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FE FE (III) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；298 K；sodium phosphate, potassium phosphate, toluene
|
Resolution 1.85 Å R-free 0.282 |
| 6TB2 Structure of human haptoglobin-hemoglobin bound to S. aureus IsdH Deposited 2019-10-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2 M sodium citrate tribasic dihydrate, 20 % w/v PEG 3350
|
Resolution 2.90 Å R-free 0.270 |
| 6XD9 Carbonmonoxy hemoglobin in complex with the antisickling agent 2-hydroxy-6-((6-(hydroxymethyl)pyridin-2-yl)methoxy)benzaldehyde (VZHE039) Deposited 2020-06-10 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V39 3-{[6-(hydroxymethyl)pyridin-2-yl]methoxy}-2-methylphenol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.4；298 K；25% PEG 6000, 0.1M HEPES
|
Resolution 2.10 Å R-free 0.258 |
| 6XDT Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 5-((2-formyl-4-methoxyphenoxy)methyl)picolinate Deposited 2020-06-11 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V1M methyl 5-[(4-methoxy-2-methylphenoxy)methyl]pyridine-2-carboxylate × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.4；298 K；25% PEG 6000, 100 mM HEPES buffer
|
Resolution 1.90 Å R-free 0.239 |
| 6XE7 Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 2-((2-formyl-3-hydroxyphenoxy)methyl)nicotinate Deposited 2020-06-12 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 V2D methyl 2-[(3-hydroxy-2-methylphenoxy)methyl]pyridine-3-carboxylate × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.4；298 K；25% PEG 6000, 10 mM HEPES
|
Resolution 2.00 Å R-free 0.251 |
| 7AET Pressure wave-exposed human hemoglobin: probe only data (3500 indexed images) Deposited 2020-09-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain AAA
3–141（139 aa）
Chain CCC
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
|
Resolution 2.53 Å R-free 0.288 |
| 7AEU Pressure wave-exposed human hemoglobin: probe only data (5500 indexed images) Deposited 2020-09-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain AAA
3–141（139 aa）
Chain CCC
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
|
Resolution 2.54 Å R-free 0.273 |
| 7AEV Pressure wave-exposed human hemoglobin: pump/probe data (3500 indexed images) Deposited 2020-09-18 | Different construct Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain AAA
3–141（139 aa）
Chain CCC
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；293 K；3.2 M NaH2PO4/ 3.2 M K2HPO4 in a 2:1 ratio
|
Resolution 2.77 Å R-free 0.273 |
| 7CUE Crystal structure of HID2 bound to human Hemoglobin Deposited 2020-08-22 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293.15 K；23% PEG 3350 (w/v), 100mM ammonium sulfate, 100mM BIS-TRIS
|
Resolution 2.75 Å R-free 0.259 |
| 7DY3 High resolution crystal structure of hemoglobin M Iwate. Deposited 2021-01-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；25%w/v PEG 3350, 0.1M HEPES-NaOH buffer, 0.2M lithium sulfate, pH 7.5
|
Resolution 1.40 Å R-free 0.193 |
| 7DY3 High resolution crystal structure of hemoglobin M Iwate. Deposited 2021-01-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；25%w/v PEG 3350, 0.1M HEPES-NaOH buffer, 0.2M lithium sulfate, pH 7.5
|
Resolution 1.40 Å R-free 0.193 |
| 7DY4 High resolution crystal structure of hemoglobin M Boston. Deposited 2021-01-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；20% w/v PEG 3350, 0.1M Bistris-HCl buffer, 0.2M magnesium chloride, pH 6.0
|
Resolution 1.30 Å R-free 0.186 |
| 7DY4 High resolution crystal structure of hemoglobin M Boston. Deposited 2021-01-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；20% w/v PEG 3350, 0.1M Bistris-HCl buffer, 0.2M magnesium chloride, pH 6.0
|
Resolution 1.30 Å R-free 0.186 |
| 7JJQ Human Hemoglobin in Complex with Nitrosoamphetamine Deposited 2020-07-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 1 K7M (2R)-N-hydroxy-1-phenylpropan-2-amine × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.74；298 K；3.2M Na/K phosphate buffer
|
Resolution 2.15 Å R-free 0.286 |
| 7JXZ Structure of HbA with compound (S)-4 Deposited 2020-08-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 VOJ 3-{(1S)-1-[5-fluoro-2-(1H-pyrazol-1-yl)phenyl]ethoxy}-5-(3-methyl-1H-pyrazol-4-yl)pyridin-2-amine × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
|
Resolution 2.23 Å R-free 0.247 |
| 7JY0 Structure of HbA with compound 9 Deposited 2020-08-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 6 VOM 2-amino-3-{(1S)-1-[5-fluoro-2-(1H-pyrazol-1-yl)phenyl]ethoxy}quinoline-6-carboxamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
|
Resolution 1.63 Å R-free 0.197 |
| 7JY1 Structure of HbA with compound 19 Deposited 2020-08-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 7 VOP [6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)-1H-indazol-1-yl]acetic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
|
Resolution 1.59 Å R-free 0.193 |
| 7JY3 Structure of HbA with compound 23 (PF-07059013) Deposited 2020-08-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 5 VUD 6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Tris-HCl, pH 8.0, 0.2 M lithium sulfate, 30-32% PEG3350
|
Resolution 1.48 Å R-free 0.207 |
| 7K4M Crystal structure of MetAP2 Modified Hemoglobin S Deposited 2020-09-15 | Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.6；293 K；0.2M Na acetate/0.1M Na cacodylate, 30% PEG-8000
|
Resolution 2.50 Å R-free 0.323 |
| 7K4M Crystal structure of MetAP2 Modified Hemoglobin S Deposited 2020-09-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
1–142（142 aa）
|
Not recorded | CMO CARBON MONOXIDE × 2 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.6；293 K；0.2M Na acetate/0.1M Na cacodylate, 30% PEG-8000
|
Resolution 2.50 Å R-free 0.323 |
| 7K4M Crystal structure of MetAP2 Modified Hemoglobin S Deposited 2020-09-15 | Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain G
1–142（142 aa）
Chain I
1–142（142 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.6；293 K；0.2M Na acetate/0.1M Na cacodylate, 30% PEG-8000
|
Resolution 2.50 Å R-free 0.323 |
| 7PCF Human methemoglobin bound to Staphylococcus aureus hemophore IsdB Deposited 2021-08-03 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.82 Å |
| 7PCH Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:2 complex Deposited 2021-08-03 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.89 Å |
| 7PCQ Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:1 complex Deposited 2021-08-03 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2；CHAPSO was added immediately before plunge freezing to overcome preferred orientation of the particles in the vitreous ice.
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.62 Å |
| 7QU4 Recombinant Human Fetal Hemoglobin mutant - alpha subunit mutations K11E,K56E,N78D,K90E Deposited 2022-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
1–142（142 aa）
|
Mutation：K11E,K56E,N78D,K90E | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293.15 K；0.2 M Sodium fluoride, 0.1 M Bis-Tris propane pH 6.5, 20 % (w/v) PEG 3350
|
Resolution 1.66 Å R-free 0.219 |
| 7QU4 Recombinant Human Fetal Hemoglobin mutant - alpha subunit mutations K11E,K56E,N78D,K90E Deposited 2022-01-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–142（142 aa）
|
Mutation：K11E,K56E,N78D,K90E | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293.15 K；0.2 M Sodium fluoride, 0.1 M Bis-Tris propane pH 6.5, 20 % (w/v) PEG 3350
|
Resolution 1.66 Å R-free 0.219 |
| 7UD7 Crystal structure of deoxygenated hemoglobin in complex with 5HMF-NO at 1.8 Angstrom Deposited 2022-03-18 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MWC dihydroxy[(5-methylfuran-2-yl)methoxy]amine × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；3.2-3.6M Sulfate/phosphate precipitant, pH 6.5, ferrous citrate
|
Resolution 1.80 Å R-free 0.191 |
| 7UD8 Crystal structure of carbon monoxy Hemoglobin in complex with 5HMF at 1.8 Angstrom Deposited 2022-03-18 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | OXY OXYGEN MOLECULE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 MW0 (5-methylfuran-2-yl)methanol × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；3.2-3.6M Sulfate/phosphate precipitant, pH 6.5, ferrous citrate
|
Resolution 1.80 Å R-free 0.228 |
| 7UF6 Crystal structure of liganded Hb with the 5-HMF analog, MMA509 Deposited 2022-03-22 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 N1X (2S)-2-(5-methylfuran-2-yl)oxane × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
|
Resolution 2.00 Å R-free 0.239 |
| 7UF7 Crystal structure of liganded Hb with the 5-HMF analog, MMA503 Deposited 2022-03-22 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 N2Q (5P)-5-(5-methylfuran-2-yl)-1H-pyrazole × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
|
Resolution 2.00 Å R-free 0.223 |
| 7UVB CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601 Deposited 2022-04-29 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 FOR FORMYL GROUP × 4 OHF 2-hydroxy-6-({(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl}methoxy)benzaldehyde × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.4；296 K；100 mM Hepes pH 7.4, 20 mM NaCl, 28-33% PEG 3350
|
Resolution 2.05 Å R-free 0.277 |
| 7VDE 3.6 A structure of the human hemoglobin Deposited 2021-09-06 | Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 7XGY cryo-EM structure of hemoglobin Deposited 2022-04-07 | Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 8DOV Crystal structure of the Shr Hemoglobin Interacting Domain 2 (HID2) in complex with Hemoglobin Deposited 2022-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
2–142（141 aa）
Fragment：Shr_HID2
Chain C
2–142（141 aa）
Fragment：Shr_HID2
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；295 K；11% PEG-6000, 100mM sodium acetate, 240mM lithium chloride
|
Resolution 2.10 Å R-free 0.238 |
| 8DOV Crystal structure of the Shr Hemoglobin Interacting Domain 2 (HID2) in complex with Hemoglobin Deposited 2022-07-14 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain E
2–142（141 aa）
Fragment：Shr_HID2
Chain G
2–142（141 aa）
Fragment：Shr_HID2
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；295 K；11% PEG-6000, 100mM sodium acetate, 240mM lithium chloride
|
Resolution 2.10 Å R-free 0.238 |
| 8EGI X-ray structure of carbonmonoxy hemoglobin in complex with VZHE039-NO Deposited 2022-09-12 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | CMO CARBON MONOXIDE × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 VZN {6-[(3-hydroxy-2-methylphenoxy)methyl]pyridin-2-yl}methyl nitrate × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；30 mg/dL of CO-ligated Hb crystallized using 10-20% PEG 6000, 100 mM Hepes, pH 7.4
|
Resolution 2.30 Å R-free 0.251 |
| 8FDK Phenylhydroxylamine in Reaction with Human Hemoglobin Deposited 2022-12-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：Shr_HID2
Chain C
2–142（141 aa）
Fragment：Shr_HID2
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 NBE NITROSOBENZENE × 5 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 6.81；298 K；3.2 M sodium/potassium phosphate
|
Resolution 1.89 Å R-free 0.246 |
| 8FDL Human Hemoglobin with Nitrosochloramphenicol Deposited 2022-12-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：Shr_HID2
Chain C
2–142（141 aa）
Fragment：Shr_HID2
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 SO4 SULFATE ION × 8 GOL GLYCEROL × 4 XQU nitrosochloramphenicol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；pH 7.4；293 K；3.6 M ammonium phosphate/sulfate
|
Resolution 1.75 Å R-free 0.210 |
| 8FDM Human Hemoglobin in Complex with Nitrosomethane Deposited 2022-12-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Fragment：Shr_HID2
Chain C
2–142（141 aa）
Fragment：Shr_HID2
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 5 MBN TOLUENE × 2 NSM NITROSOMETHANE × 2 PO4 PHOSPHATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；298 K；3.2 M sodium/potassium phosphate
|
Resolution 1.91 Å R-free 0.253 |
| 8FDN Human Hemoglobin with N-tertbutylhydroxylamine Deposited 2022-12-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | GOL GLYCEROL × 4 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 XQZ N-T-Butylhydroxylamine × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
BATCH MODE；298 K；3.2 M sodium/potassium phosphate
|
Resolution 2.20 Å R-free 0.291 |
| 8VYL The structure of Human Hemoglobin in Complex with Nanobody BtNbE11 Deposited 2024-02-08 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
1–142（142 aa）
Chain C
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 ACE ACETYL GROUP × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.1-0.3M NH4 Acet. pH 5.5, 0.1-0.3M Na Acet., 25% w/v PEG3350
|
Resolution 2.02 Å R-free 0.266 |
| 8WJ0 cryo-EM structure of human haemoglobin in carbonmonoxy form Deposited 2023-09-25 | Different construct Different mutation/modification Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.24 Å |
| 8WJ1 cryo-EM structure of human haemoglobin in oxy form Deposited 2023-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.27 Å |
| 8WJ2 cryo-EM structure of human haemoglobin in deoxy form Deposited 2023-09-25 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.35 Å |
| 8WXW Falcilysin in complex with hemoglobin alpha chain peptide Deposited 2023-10-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
35–48（14 aa）
|
Not recorded | GOL GLYCEROL × 4 EDO 1,2-ETHANEDIOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；4% w/v PEG 1500, 20% v/v glycerol
|
Resolution 1.86 Å R-free 0.210 |
| 8XMP Structure of CD163 in complex with Hb-Hp Deposited 2023-12-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain C
1–142（142 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 10 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.11 Å |
| 8XMQ Structure of dimeric CD163 in complex with Hb-Hp Deposited 2023-12-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric |
Chain C
1–142（142 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 7 CA CALCIUM ION × 12 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |
| 8XMW Local refinement of Hb-Hp bind to CD163 Deposited 2023-12-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric |
Chain A
1–142（142 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 6 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.94 Å |
| 9AV9 R2-state HbG-Makassar hemoglobin Deposited 2024-03-01 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | GOL GLYCEROL × 5 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8；298 K；0.1 M TRIS pH 8.0; 26-36% (v/v) PEG 6,000
|
Resolution 1.94 Å R-free 0.222 |
| 9AYZ T-state HbG Makassar hemoglobin Deposited 2024-03-09 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；0.055 M Citric acid, 0.045 M Bis-Tris propane, pH 4.5, 22% PEG 3,350 under low oxygen conditions on an MBraun anaerobic glove box
|
Resolution 2.24 Å R-free 0.259 |
| 9AYZ T-state HbG Makassar hemoglobin Deposited 2024-03-09 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–142（141 aa）
Chain G
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；0.055 M Citric acid, 0.045 M Bis-Tris propane, pH 4.5, 22% PEG 3,350 under low oxygen conditions on an MBraun anaerobic glove box
|
Resolution 2.24 Å R-free 0.259 |
| 9BCJ Crystal structure of human hemoglobin in complex with the HbpA receptor from Corynebacterium diphtheriae Deposited 2024-04-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain A
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 6 PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；20% PEG-2000 MME, 100 mM Tris, 240 mM TMAO
|
Resolution 1.69 Å R-free 0.215 |
| 9CQM Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 25 uM sodium dithionite under Al's oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–141（139 aa）
Chain C
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.55 Å |
| 9CQN Human OxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 25 uM sodium dithionite under Al's oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–141（139 aa）
Chain C
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.37 Å |
| 9CQO Human metHb (C1 symmetry) obtained using the SPT Labtech chameleon Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 3.01 Å |
| 9CQP Human metHb (C2 symmetry) obtained using the SPT Labtech chameleon Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.78 Å |
| 9CQQ Human metHb (C1 symmetry) obtained using the SPT Labtech chameleon under Al's Oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.91 Å |
| 9CQR Human metHb (C2 symmetry) obtained using the SPT Labtech chameleon under Al's Oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.70 Å |
| 9CQS Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 5 mM sodium dithionite under Al's oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–141（139 aa）
Chain C
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.52 Å |
| 9CQT Human OxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 5 mM sodium dithionite under Al's oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–141（139 aa）
Chain C
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.37 Å |
| 9CQU Human OxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 20 mM sodium dithionite under Al's oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–141（139 aa）
Chain C
3–141（139 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.72 Å |
| 9CQV Human DeoxyHb (C1 symmetry) obtained using the SPT Labtech chameleon In the presence of 60 mM sodium dithionite under Al's oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.75 Å |
| 9CQW Human DeoxyHb (C2 symmetry) obtained using the SPT Labtech chameleon In the presence of 60 mM sodium dithionite under Al's oil Deposited 2024-07-19 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–141（140 aa）
Chain C
2–141（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE；Samples were frozen with the SPT Labtech chameleon
|
Resolution 2.61 Å |
| 9FHB Cryo-EM structure of human CD163 SRCR2-4 in complex with haptoglobin-hemoglobin Deposited 2024-05-27 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 CA CALCIUM ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.87 Å |
| 9FMU Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 CA CALCIUM ION × 3 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.46 Å |
| 9FNO Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin Deposited 2024-06-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 CA CALCIUM ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.6
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.20 Å |
| 9HBA Crystal structure of C35 bound to Hem Deposited 2024-11-05 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–142（141 aa）
Chain C
2–142（141 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 GOL GLYCEROL × 6 A1ITR 4-[2-[[5-(1H-indol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]benzoic acid × 3 DMS DIMETHYL SULFOXIDE × 8 CMO CARBON MONOXIDE × 4 ACY ACETIC ACID × 2 SO4 SULFATE ION × 16 PGE TRIETHYLENE GLYCOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；3.0 M Ammonium sulfate; 1% (w/v) MPD
|
Resolution 1.51 Å R-free 0.215 |
| 9HEJ Dimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain D
1–142（142 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 9 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.82 Å |
| 9HEK Trimeric CD163 bound to human haptoglobin-haemoglobin complex Deposited 2024-11-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 6 PDB declaration: hexameric |
Chain D
1–142（142 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 CA CALCIUM ION × 19 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.15 Å |
| 9NB6 Cryo-EM structure of the CD163/Hp(1-1)Hb complex Deposited 2025-02-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric |
Chain D
1–142（142 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 9 CA CALCIUM ION × 23 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9NB8 Cryo-EM structure of the CD163/HpSPHb complex Deposited 2025-02-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric |
Chain D
1–142（142 aa）
|
Not recorded | CA CALCIUM ION × 21 HEM PROTOPORPHYRIN IX CONTAINING FE × 2 OXY OXYGEN MOLECULE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.00 Å |
| 9S3P Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 3IsdH(alpha2beta):Hbtet complex Deposited 2025-07-24 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric |
Chain A
3–142（140 aa）
Chain C
3–142（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE；blot time 3 s
|
Resolution 3.10 Å |
| 9S4F Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 right tail Deposited 2025-07-28 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–142（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE；blot time 3 s
|
Resolution 4.20 Å |
| 9S4I Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 left tail Deposited 2025-07-28 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–142（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE；blot time 3 s
|
Resolution 4.00 Å |
| 9S4J Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 0 right tail Deposited 2025-07-28 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–142（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE；blot time 3 s
|
Resolution 4.10 Å |
| 9S4K Human carboxyhemoglobin bound to Staphylococcus aureus IsdH-N2N3 - 2IsdH:Hbdim complex - 3DVA component 4 left tail Deposited 2025-07-28 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
3–142（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE；blot time 3 s
|
Resolution 4.00 Å |
| 9SZW Human carboxyhemoglobin bound to full-length Staphylococcus aureus IsdH - IsdH:Hbdim complex Deposited 2025-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
3–142（140 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE；blot time 3 s
|
Resolution 3.14 Å |
| 9TQD CD163 bound to haemoglobin Deposited 2025-12-20 | Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric |
Chain D
1–142（142 aa）
Chain F
1–142（142 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 8 CA CALCIUM ION × 16 HEM PROTOPORPHYRIN IX CONTAINING FE × 4 OXY OXYGEN MOLECULE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.80 Å |
| 9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 | Different construct Different mutation/modification Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.26 Å |
| 9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.26 Å |
| 9VIB cryo-EM structure of human haemoglobin in the R2 conformation Deposited 2025-06-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.26 Å |
| 9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 | Different construct Different mutation/modification Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 4 CMO CARBON MONOXIDE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.45 Å |
| 9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.45 Å |
| 9VIC cryo-EM structure of human haemoglobin in the R conformation Deposited 2025-06-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
1–142（142 aa）
|
Not recorded | HEM PROTOPORPHYRIN IX CONTAINING FE × 2 CMO CARBON MONOXIDE × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.45 Å |
348 other PDB entries and 410 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | HBA_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–142； UniProt 1–142 Author chain C； PDBConstruct 1–142； UniProt 1–142 Author chain E； PDBConstruct 1–142； UniProt 1–142 Author chain G； PDBConstruct 1–142； UniProt 1–142 Author chain I； PDBConstruct 1–142； UniProt 1–142 Author chain K； PDBConstruct 1–142； UniProt 1–142 |
