6mrt

12-meric ClyA pore complex

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Hemolysin E, chromosomal

Escherichia coli (strain K12)

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 12	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	HLYE_ECOLI
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 22–324； UniProt 1–303 Author chain B； PDBConstruct 22–324； UniProt 1–303 Author chain C； PDBConstruct 22–324； UniProt 1–303 Author chain D； PDBConstruct 22–324； UniProt 1–303 Author chain E； PDBConstruct 22–324； UniProt 1–303 Author chain F； PDBConstruct 22–324； UniProt 1–303 Author chain G； PDBConstruct 22–324； UniProt 1–303 Author chain H； PDBConstruct 22–324； UniProt 1–303 Author chain I； PDBConstruct 22–324； UniProt 1–303 Author chain J； PDBConstruct 22–324； UniProt 1–303 Author chain K； PDBConstruct 22–324； UniProt 1–303 Author chain L； PDBConstruct 22–324； UniProt 1–303

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	6mrt
Deposition date deposition_date	2018-10-15
Structure title title	12-meric ClyA pore complex
Keywords keywords	Pore-forming toxin, MEMBRANE PROTEIN, Toxin; MEMBRANE PROTEIN, Toxin
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6mrt__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6mrt__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

6mrt__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	56.30 Å
Rg (electron density)	56.20 Å
Total Rg	56.42 Å
Atom count	26868
Residues	3420
Excluded volume	483420 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`6mrt__assembly_1__model_1`	dodecameric （12）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

Domain ID domain_id	d6mrta_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtb_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtc_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtd_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrte_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtf_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtg_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrth_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrti_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtj_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtk_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

Domain ID domain_id	d6mrtl_
Class class	h — Coiled coil proteins
Fold Fold fold	h.4 — Antiparallel coiled-coil
Superfamily Superfamily superfamily	h.4.4 — Bacterial hemolysins
Family Family family	h.4.4.1 — Hemolysin E (HlyE, ClyA, SheA)

CATH v4.4 (12 domains)

Domain ID domain_id	6mrtA00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtB00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtC00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtD00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtE00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtF00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtG00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtH00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtI00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtJ00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtK00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6mrtL00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1170 — Hemolysin E; Chain: A;
Homologous superfamily homologous superfamily	10 —

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.80 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	482946

Description description	Hemolysin E, chromosomal
Molecular weight formula_weight	36131.8 kDa
Source method src_method	man
Copy count entity_count	12

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,I,J,K,L
Atom count atom_count	26868

12-meric ClyA pore complex

1. Protein Identity and Related Structures Protein Identity & Related Structures

Hemolysin E, chromosomal

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

6mrt__assembly_1__model_1

6mrt__assembly_1__model_1 | I(q)

6mrt__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

CATH v4.4 (12 domains)

7. Citations (1)

Source organism organism	Escherichia coli (strain K12)
NCBI taxonomy ID ncbi_taxonomy_id	83333
Host organism host_organism	Escherichia coli

12-meric ClyA pore complex

1. Protein Identity and Related Structures Protein Identity & Related Structures

Hemolysin E, chromosomal

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

6mrt__assembly_1__model_1

6mrt__assembly_1__model_1 | I(q)

6mrt__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

CATH v4.4 (12 domains)

7. Citations (1)