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6ula

Crystal structure of human GAC in complex with inhibitor UPGL00012

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Glutaminase kidney isoform, mitochondrial

Homo sapiens

UniProt O94925

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 4 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 4 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
5jyo 5jyo 5jyo 5jyo 5jyo 5jyo 5jyo 5jyo

8 assemblies

Homodimer
3czd 5fi2 5fi2 5u0i 5u0j 5u0j 5wj6 5wj6 8gwr

9 assemblies

Homotetramer
3unw 3uo9 3voy 3voz 3vp0 3vp1 3vp2 3vp3 3vp4 4o7d 5d3o 5fi2

49 assemblies; showing the first 12

Other homooligomers
8szj

1 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name GLSK_HUMAN
Isoform O94925-3
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–527； UniProt 72–598 Author chain B； PDBConstruct 1–527； UniProt 72–598 Author chain C； PDBConstruct 1–527； UniProt 72–598 Author chain D； PDBConstruct 1–527； UniProt 72–598 Author chain E； PDBConstruct 1–527； UniProt 72–598 Author chain F； PDBConstruct 1–527； UniProt 72–598 Author chain G； PDBConstruct 1–527； UniProt 72–598 Author chain H； PDBConstruct 1–527； UniProt 72–598

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6ula
Deposition date deposition_date2019-10-07
Structure title titleCrystal structure of human GAC in complex with inhibitor UPGL00012
Keywords keywordsInhibitor, Complex, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6ula__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6ula__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6ula__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.67 Å
Rg (electron density)43.06 Å
Total Rg43.36 Å
Atom count12834
Residues1639
Excluded volume229540 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6ula__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6ula__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (4)