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6ulv

BRD4-BD1 in complex with the cyclic peptide 4.2_1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Bromodomain-containing protein 4

Homo sapiens

UniProt O60885

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Cyclic peptide 4.2_3 × 1 IODIDE ION × 4 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 1 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Cyclic peptide 4.2_3 × 1 IODIDE ION × 3 GLYCEROL × 1 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2i8n 2oss 2ouo 2yel 2yem 2yem 3mxf 3p5o 3svf 3svg 3u5j 3u5k

655 assemblies; showing the first 12

Homodimer
5khm 6djc 7dhs 7l9m 7la9 7la9 7la9 7mr5 7mr6 7mr7

10 assemblies

Homotetramer

None

Other homooligomers
8wxy 8wy3 8wy7

3 assemblies

Heteromeric or nucleic-acid complex
2lsp 2mjv 2n3k 2ncz 2nd0 2nd1 2nnu 2nnu 3uvw 3uvx 3uvy 3uw9

111 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name BRD4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–133； UniProt 42–168 Author chain B； PDBConstruct 7–133； UniProt 42–168 Author chain C； PDBConstruct 7–133； UniProt 42–168 Author chain D； PDBConstruct 7–133； UniProt 42–168

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6ulv
Deposition date deposition_date2019-10-08
Structure title titleBRD4-BD1 in complex with the cyclic peptide 4.2_1
Keywords keywordsBET, bromodomain, macrocyclic peptide, BRD4, inhibitor, RaPID, TRANSCRIPTION-INHIBITOR complex, TRANSCRIPTION; TRANSCRIPTION/INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6ulv__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6ulv__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6ulv__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.02 Å
Rg (electron density)22.38 Å
Total Rg23.16 Å
Atom count2016
Residues228
Excluded volume36642 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6ulv__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6ulv__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)