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6uwy

DYRK1A bound to a harmine derivative

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Homo sapiens

UniProt Q13627

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide × 1 TETRAETHYLENE GLYCOL × 3 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide × 1 TETRAETHYLENE GLYCOL × 3 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide × 1 TETRAETHYLENE GLYCOL × 2 Consistent with protein count
4 Protein monomer Monomer Protein 1 4-(7-methoxy-1-methyl-9H-beta-carbolin-9-yl)butanamide × 1 TETRAETHYLENE GLYCOL × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2vx3 2vx3 2vx3 2vx3 2wo6 3anq 3anq 3anq 3anq 3anr 3anr 3anr

223 assemblies; showing the first 12

Homodimer

None

Homotetramer
4nct 8c3g

2 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
2wo6 4aze 4aze 4aze

4 assemblies

View Construct and Data Evidence
UniProt name DYR1A_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–361； UniProt 127–485 Author chain B； PDBConstruct 3–361； UniProt 127–485 Author chain C； PDBConstruct 3–361； UniProt 127–485 Author chain D； PDBConstruct 3–361； UniProt 127–485

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6uwy
Deposition date deposition_date2019-11-05
Structure title titleDYRK1A bound to a harmine derivative
Keywords keywordskinase, TRANSFERASE, TRANSFERASE-TRANSFERASE Inhibitor complex; TRANSFERASE/TRANSFERASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6uwy__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6uwy__assembly_3__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6uwy__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.87 Å
Rg (electron density)21.69 Å
Total Rg22.51 Å
Atom count2897
Residues346
Excluded volume51632 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6uwy__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6uwy__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6uwy__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 6uwy__assembly_4__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd6uwya_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd6uwyb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd6uwyc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd6uwyd_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
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7. Citations (1)