← Back to search
6vgi

Crystal Structures of FLAP bound to MK-866

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

5-lipoxygenase-activating protein

Homo sapiens

UniProt P20292

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid × 3 SULFATE ION × 3 water × 3 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 3 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid × 3 SULFATE ION × 2 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
2q7m 2q7m 2q7r 2q7r 6vgc 6vgc 6vgi 6vgi

8 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name AL5AP_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–163； UniProt 2–161 Author chain B； PDBConstruct 4–163； UniProt 2–161 Author chain C； PDBConstruct 4–163； UniProt 2–161 Author chain D； PDBConstruct 4–163； UniProt 2–161 Author chain E； PDBConstruct 4–163； UniProt 2–161 Author chain F； PDBConstruct 4–163； UniProt 2–161

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id6vgi
Deposition date deposition_date2020-01-08
Structure title titleCrystal Structures of FLAP bound to MK-866
Keywords keywords5-Lipoxygenase Activating Protein, FLAP, MK-866, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6vgi__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6vgi__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6vgi__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.81 Å
Rg (electron density)25.27 Å
Total Rg26.04 Å
Atom count3586
Residues437
Excluded volume65440 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6vgi__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6vgi__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (4)

▼

6. Fold Classification (SCOP + CATH) 6 domains

CATH v4.4 (6 domains)

Domain ID domain_id6vgiA01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily550 — Membrane associated eicosanoid/glutathione metabolism-like domain
Domain ID domain_id6vgiB01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily550 — Membrane associated eicosanoid/glutathione metabolism-like domain
Domain ID domain_id6vgiC01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily550 — Membrane associated eicosanoid/glutathione metabolism-like domain
Domain ID domain_id6vgiD01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily550 — Membrane associated eicosanoid/glutathione metabolism-like domain
Domain ID domain_id6vgiE01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily550 — Membrane associated eicosanoid/glutathione metabolism-like domain
Domain ID domain_id6vgiF01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily550 — Membrane associated eicosanoid/glutathione metabolism-like domain
▶

7. Citations (1)