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6z0e

HtrA1 inactive protease domain S328A with CARASIL mutation R274Q

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Serine protease HTRA1

Homo sapiens

UniProt Q92743

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 3 CALCIUM ION × 3 water × 3 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 3 CALCIUM ION × 3 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2ytw 3tjq

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
3num 3nwu 3nwu 3tjn 3tjn 3tjn 3tjo 6z0e 6z0e 6z0x 6z0x 6z0x

15 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2joa 3nzi 7sjn 7sjo 8sdm 8sdp 8se7 8se7 8se7 8se7 8se8 8se8

14 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HTRA1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 22–236； UniProt 161–375 Author chain B； PDBConstruct 22–236； UniProt 161–375

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6z0e
Deposition date deposition_date2020-05-08
Structure title titleHtrA1 inactive protease domain S328A with CARASIL mutation R274Q
Keywords keywordsHydrolase Protease HtrA family CARASIL mutations trimerization, HYDROLASE; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6z0e__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6z0e__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6z0e__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.56 Å
Rg (electron density)26.70 Å
Total Rg27.55 Å
Atom count4492
Residues588
Excluded volume80831 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6z0e__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6z0e__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd6z0ea_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.0 — automated matches
Domain ID domain_idd6z0eb_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.0 — automated matches
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7. Citations (1)