6zol

SARS-CoV-2-Nsp1-40S complex, focused on head

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

40S ribosomal protein S3

物种未注明

UniProt P23396

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS3_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 D; PDB构建体 1–243; UniProt 1–243

40S ribosomal protein S5

物种未注明

UniProt P46782

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS5_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 F; PDB构建体 1–204; UniProt 1–204

40S ribosomal protein S10

物种未注明

UniProt P46783

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS10_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 K; PDB构建体 1–165; UniProt 1–165

40S ribosomal protein S12

物种未注明

UniProt P25398

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS12_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 M; PDB构建体 1–132; UniProt 1–132

40S ribosomal protein S15

物种未注明

UniProt P62841

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS15_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 P; PDB构建体 1–145; UniProt 1–145

40S ribosomal protein S16

物种未注明

UniProt P62249

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS16_HUMAN
Isoform —
PDB实体 7
链与序列区间 作者链 Q; PDB构建体 1–146; UniProt 1–146

40S ribosomal protein S17

物种未注明

UniProt P08708

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS17_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 R; PDB构建体 1–135; UniProt 1–135

40S ribosomal protein S18

物种未注明

UniProt P62269

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS18_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 S; PDB构建体 1–152; UniProt 1–152

40S ribosomal protein S19

物种未注明

UniProt P39019

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS19_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 T; PDB构建体 1–145; UniProt 1–145

40S ribosomal protein S20

物种未注明

UniProt P60866

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS20_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 U; PDB构建体 1–119; UniProt 1–119

40S ribosomal protein S25

物种未注明

UniProt P62851

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS25_HUMAN
Isoform —
PDB实体 12
链与序列区间 作者链 Z; PDB构建体 1–125; UniProt 1–125

40S ribosomal protein S28

物种未注明

UniProt P62857

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS28_HUMAN
Isoform —
PDB实体 13
链与序列区间 作者链 c; PDB构建体 1–61; UniProt 8–68

40S ribosomal protein S29

物种未注明

UniProt P62273

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) Ribosomal protein S27a × 1 (Q5RKT7) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RS29_HUMAN
Isoform —
PDB实体 14
链与序列区间 作者链 d; PDB构建体 1–55; UniProt 2–56

Ribosomal protein S27a

物种未注明

UniProt Q5RKT7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Receptor of activated protein C kinase 1 × 1 (P63244) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q5RKT7_HUMAN
Isoform —
PDB实体 15
链与序列区间 作者链 f; PDB构建体 1–72; UniProt 78–149

Receptor of activated protein C kinase 1

物种未注明

UniProt P63244

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 15 RNA 1 18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 (P23396) 40S ribosomal protein S5 × 1 (P46782) 40S ribosomal protein S10 × 1 (P46783) 40S ribosomal protein S12 × 1 (P25398) 40S ribosomal protein S15 × 1 (P62841) 40S ribosomal protein S16 × 1 (P62249) 40S ribosomal protein S17 × 1 (P08708) 40S ribosomal protein S18 × 1 (P62269) 40S ribosomal protein S19 × 1 (P39019) 40S ribosomal protein S20 × 1 (P60866) 40S ribosomal protein S25 × 1 (P62851) 40S ribosomal protein S28 × 1 (P62857) 40S ribosomal protein S29 × 1 (P62273) Ribosomal protein S27a × 1 (Q5RKT7) MAGNESIUM ION × 57 ZINC ION × 2 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RACK1_HUMAN
Isoform —
PDB实体 16
链与序列区间 作者链 g; PDB构建体 1–315; UniProt 1–315

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6zol
沉积日期 deposition_date2020-07-07
结构标题 titleSARS-CoV-2-Nsp1-40S complex, focused on head
关键词 keywordsinhibitor, mRNA channel, 40S ribosomal subunit, TRANSLATION; TRANSLATION
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

6zol__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

6zol__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

6zol__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)46.17 Å
Rg(电子密度)47.82 Å
总 Rg47.80 Å
原子数25591
残基数2416
排除体积421070 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 6zol__assembly_1__model_1 hexadecameric (16) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (18)

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6. 折叠分类 (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

结构域编号 domain_idd6zolg_
类 Class classb — All beta proteins
折叠类型 Fold foldb.69 — 7-bladed beta-propeller
超家族 Superfamily superfamilyb.69.4 — WD40 repeat-like
家族 Family familyb.69.4.1 — WD40-repeat

CATH v4.4 (1 domains)

结构域编号 domain_id6zolD01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology300 — GMP Synthetase; Chain A, domain 3
同源超家族 H-superfamily homologous superfamily20 — K homology (KH) domain
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7. 引用文献 (1)