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7aqt

NMR2 structure of BRD4-BD2 in complex with iBET-762

Method: SOLUTION NMR
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Bromodomain-containing protein 4

Homo sapiens

UniProt O60885

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2i8n 2oss 2ouo 2yel 2yem 2yem 3mxf 3p5o 3svf 3svg 3u5j 3u5k

655 assemblies; showing the first 12

Homodimer
5khm 6djc 7dhs 7l9m 7la9 7la9 7la9 7mr5 7mr6 7mr7

10 assemblies

Homotetramer

None

Other homooligomers
8wxy 8wy3 8wy7

3 assemblies

Heteromeric or nucleic-acid complex
2lsp 2mjv 2n3k 2ncz 2nd0 2nd1 2nnu 2nnu 3uvw 3uvx 3uvy 3uw9

111 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name BRD4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–109； UniProt 351–459

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7aqt
Deposition date deposition_date2020-10-23
Structure title titleNMR2 structure of BRD4-BD2 in complex with iBET-762
Keywords keywordsBRD4, BD2, bromodomain, iBET-762, NMR2, ONCOPROTEIN; ONCOPROTEIN
Experimental Method methodSOLUTION NMR
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7aqt__assembly_1__model_9

Assembly 1 · Model 9 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7aqt__assembly_1__model_9 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7aqt__assembly_1__model_9 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）15.50 Å
Rg (electron density)14.21 Å
Total Rg15.42 Å
Atom count1811
Residues109
Excluded volume16426 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7aqt__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 7aqt__assembly_1__model_2 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 7aqt__assembly_1__model_3 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 7aqt__assembly_1__model_4 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 7aqt__assembly_1__model_5 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 7aqt__assembly_1__model_6 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 7aqt__assembly_1__model_7 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 7aqt__assembly_1__model_8 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 7aqt__assembly_1__model_9 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 7aqt__assembly_1__model_10 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)