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7cvy

Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Capsid protein

OrganismNot specified

UniProt A0A6B9KBE1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1200 Fab heavy chain × 240 Fab light chain × 240 E1 glycoprotein × 240 （D7R998） E2 glycoprotein × 240 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 20 Fab heavy chain × 4 Fab light chain × 4 E1 glycoprotein × 4 （D7R998） E2 glycoprotein × 4 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 100 Fab heavy chain × 20 Fab light chain × 20 E1 glycoprotein × 20 （D7R998） E2 glycoprotein × 20 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 120 Fab heavy chain × 24 Fab light chain × 24 E1 glycoprotein × 24 （D7R998） E2 glycoprotein × 24 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 20 Fab heavy chain × 4 Fab light chain × 4 E1 glycoprotein × 4 （D7R998） E2 glycoprotein × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7cvy 7cvy 7cvy 7cvy 7cvy 7cvz 7cvz 7cvz 7cvz 7cvz 7cw0 7cw0

21 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name A0A6B9KBE1_CHIKV
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–151； UniProt 111–261 Author chain H； PDBConstruct 1–151； UniProt 111–261 Author chain M； PDBConstruct 1–151； UniProt 111–261 Author chain R； PDBConstruct 1–151； UniProt 111–261

E1 glycoprotein

OrganismNot specified

UniProt D7R998

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 1200 Fab heavy chain × 240 Fab light chain × 240 Capsid protein × 240 （A0A6B9KBE1） E2 glycoprotein × 240 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 20 Fab heavy chain × 4 Fab light chain × 4 Capsid protein × 4 （A0A6B9KBE1） E2 glycoprotein × 4 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 100 Fab heavy chain × 20 Fab light chain × 20 Capsid protein × 20 （A0A6B9KBE1） E2 glycoprotein × 20 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 120 Fab heavy chain × 24 Fab light chain × 24 Capsid protein × 24 （A0A6B9KBE1） E2 glycoprotein × 24 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 20 Fab heavy chain × 4 Fab light chain × 4 Capsid protein × 4 （A0A6B9KBE1） E2 glycoprotein × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7cvy 7cvy 7cvy 7cvy 7cvy

5 assemblies

View Construct and Data Evidence
UniProt name D7R998_CHIKV
Isoform —
PDB entities 4
Chains and sequence ranges Author chain A； PDBConstruct 1–439； UniProt 810–1248 Author chain F； PDBConstruct 1–439； UniProt 810–1248 Author chain K； PDBConstruct 1–439； UniProt 810–1248 Author chain P； PDBConstruct 1–439； UniProt 810–1248

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7cvy
Deposition date deposition_date2020-08-27
Structure title titleCryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124
Keywords keywordsCHIKV, Fab, complex, VIRUS, IMMUNE SYSTEM-VIRUS complex; IMMUNE SYSTEM/VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7cvy__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7cvy__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 1012 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7cvy__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）0.00 Å
Rg (electron density)301.10 Å
Total Rg301.10 Å
Atom count0
Residues0
Excluded volume46063000 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7cvy__assembly_1__model_1 1200-meric （1200） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7cvy__assembly_2__model_1 eicosameric （20） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 7cvy__assembly_3__model_1 100-meric （100） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 7cvy__assembly_4__model_1 120-meric （120） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 7cvy__assembly_5__model_1 eicosameric （20） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)