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7kev

PCSK9 in complex with a cyclic peptide LDLR disruptor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proprotein convertase subtilisin/kexin type 9 Propeptide

Homo sapiens

UniProt Q8NBP7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 cyclic peptide LDLR disruptor × 1 CALCIUM ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2p4e 2p4e 6u26 6u26

4 assemblies

Homodimer
2p4e 2qtw 4k8r 6u2n 6u2p 6u3x 8wfr 9hz3 9szy

9 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
10sb 2w2m 2w2n 2w2o 2w2p 2w2q 2xtj 3bps 3gcw 3gcx 3h42 3m0c

56 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PCSK9_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–124； UniProt 29–152 Author chain B； PDBConstruct 1–540； UniProt 153–692

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7kev
Deposition date deposition_date2020-10-12
Structure title titlePCSK9 in complex with a cyclic peptide LDLR disruptor
Keywords keywords;PRO-PROTEIN CONVERTASE, CORONARY HEART DISEASE, HYPERCHOLESTEROLEMIA, LOW DENSITY LIPOPROTEIN RECEPTOR, AUTOCATALYTIC CLEAVAGE, CHOLESTEROL METABOLISM, DISEASE MUTATION, GLYCOPROTEIN, HYDROLASE, LIPID METABOLISM, PHOSPHORYLATION, PROTEASE, SECRETED, SERINE PROTEASE, STEROID METABOLISM, ZYMOGEN, LIPID TRANSPORT ;; LIPID TRANSPORT, HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7kev__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7kev__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7kev__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.12 Å
Rg (electron density)25.00 Å
Total Rg25.81 Å
Atom count4362
Residues572
Excluded volume77103 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7kev__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (2)