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7kvh

Human CYP3A4 bound to an inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytochrome P450 3A4

Homo sapiens

UniProt P08684

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 PROTOPORPHYRIN IX CONTAINING FE × 2 tert-butyl [(2S)-1-{[(2R)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1tqn 1w0e 1w0f 1w0g 2j0d 2j0d 2v0m 2v0m 2v0m 2v0m 3nxu 3nxu

53 assemblies; showing the first 12

Homodimer
5g5j 5vc0 5vcc 5vcd 5vce 5vcg 6bd7 6bd8 6bdh 6bdi 6bdm 6ma6

71 assemblies; showing the first 12

Homotetramer
1tqn 4i3q 4i4g 4i4h 4ny4 5vc0 5vcc 5vcd 5vce 5vcg 6bcz 6bd5

27 assemblies; showing the first 12

Other homooligomers
5te8

1 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name CP3A4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–483； UniProt 1–503 Author chain B； PDBConstruct 1–483； UniProt 1–503

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7kvh
Deposition date deposition_date2020-11-28
Structure title titleHuman CYP3A4 bound to an inhibitor
Keywords keywordsCYP3A4, inhibitor, complex, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex; OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7kvh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7kvh__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7kvh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.30 Å
Rg (electron density)30.61 Å
Total Rg31.33 Å
Atom count7353
Residues895
Excluded volume133910 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7kvh__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd7kvha_
Class classa — All alpha proteins
Fold Fold folda.104 — Cytochrome P450
Superfamily Superfamily superfamilya.104.1 — Cytochrome P450
Family Family familya.104.1.1 — Cytochrome P450
Domain ID domain_idd7kvhb_
Class classa — All alpha proteins
Fold Fold folda.104 — Cytochrome P450
Superfamily Superfamily superfamilya.104.1 — Cytochrome P450
Family Family familya.104.1.1 — Cytochrome P450
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7. Citations (1)