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7kvj

Human CYP3A4 bound to an inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytochrome P450 3A4

Homo sapiens

UniProt P08684

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 PROTOPORPHYRIN IX CONTAINING FE × 2 tert-butyl [(2S)-1-{[(2S)-1-oxo-3-phenyl-1-{[3-(pyridin-3-yl)propyl]amino}propan-2-yl]sulfanyl}-3-phenylpropan-2-yl]carbamate × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1tqn 1w0e 1w0f 1w0g 2j0d 2j0d 2v0m 2v0m 2v0m 2v0m 3nxu 3nxu

53 assemblies; showing the first 12

Homodimer
5g5j 5vc0 5vcc 5vcd 5vce 5vcg 6bd7 6bd8 6bdh 6bdi 6bdm 6ma6

71 assemblies; showing the first 12

Homotetramer
1tqn 4i3q 4i4g 4i4h 4ny4 5vc0 5vcc 5vcd 5vce 5vcg 6bcz 6bd5

27 assemblies; showing the first 12

Other homooligomers
5te8

1 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name CP3A4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–483； UniProt 1–503

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7kvj
Deposition date deposition_date2020-11-28
Structure title titleHuman CYP3A4 bound to an inhibitor
Keywords keywordsCYP3A4, inhibitor, complex, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex; OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7kvj__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7kvj__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7kvj__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）35.20 Å
Rg (electron density)34.83 Å
Total Rg35.22 Å
Atom count6814
Residues830
Excluded volume124150 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7kvj__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 1 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd7kvja_
Class classa — All alpha proteins
Fold Fold folda.104 — Cytochrome P450
Superfamily Superfamily superfamilya.104.1 — Cytochrome P450
Family Family familya.104.1.1 — Cytochrome P450
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7. Citations (1)