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7lk0

Ornithine Aminotransferase (OAT) cocrystallized with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Ornithine aminotransferase, mitochondrial

Homo sapiens

UniProt P04181

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 (1R,3S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxocyclopentane-1-carboxylic acid × 2 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 (1R,3S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxocyclopentane-1-carboxylic acid × 2 water × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 2 (1R,3S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxocyclopentane-1-carboxylic acid × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7t9z 7t9z 7t9z 7ta1 7ta1 7ta1 7ta1 7ta1 7ta1

9 assemblies

Homodimer
10lw 10lw 10lx 10lx 1gbn 1gbn 1oat 1oat 2byj 2byj 2byl 2byl

56 assemblies; showing the first 12

Homotetramer
1gbn 2oat

2 assemblies

Other homooligomers
1gbn 5vwo

2 assemblies

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name OAT_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–404； UniProt 36–439 Author chain B； PDBConstruct 1–404； UniProt 36–439 Author chain C； PDBConstruct 1–404； UniProt 36–439

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7lk0
Deposition date deposition_date2021-02-01
Structure title titleOrnithine Aminotransferase (OAT) cocrystallized with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148)
Keywords keywordsOrnithine Aminotransferase, OAT, aminotransferase, inhibitor, inactivator, SS-1-148, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7lk0__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7lk0__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7lk0__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.90 Å
Rg (electron density)25.96 Å
Total Rg26.83 Å
Atom count6336
Residues804
Excluded volume113520 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7lk0__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7lk0__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 7lk0__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)