7oih

Glycosylation in the crystal structure of neutrophil myeloperoxidase

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Myeloperoxidase

物种未注明

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	其他组合	同源多聚体	蛋白 2 其他聚合物 6	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 ;alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 CHLORIDE ION × 10 CALCIUM ION × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 THIOCYANATE ION × 3 Paroxetine × 1 PHOSPHATE ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 water × 2	与蛋白数一致
2	其他组合	同源多聚体	蛋白 2 其他聚合物 6	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 ;alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 CHLORIDE ION × 8 CALCIUM ION × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 THIOCYANATE ION × 3 Paroxetine × 1 PHOSPHATE ION × 5 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 water × 2	与蛋白数一致
3	其他组合	同源多聚体	蛋白 2 其他聚合物 6	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 CHLORIDE ION × 9 CALCIUM ION × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 THIOCYANATE ION × 2 Paroxetine × 1 PHOSPHATE ION × 2 water × 2	与蛋白数一致
4	其他组合	同源多聚体	蛋白 2 其他聚合物 7	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 2 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ;alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 CHLORIDE ION × 9 CALCIUM ION × 2 PROTOPORPHYRIN IX CONTAINING FE × 2 THIOCYANATE ION × 2 Paroxetine × 1 PHOSPHATE ION × 4 water × 2	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	PERM_HUMAN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–579； UniProt 166–744 作者链 B； PDB构建体 1–579； UniProt 166–744 作者链 C； PDB构建体 1–579； UniProt 166–744 作者链 D； PDB构建体 1–579； UniProt 166–744 作者链 E； PDB构建体 1–579； UniProt 166–744 作者链 F； PDB构建体 1–579； UniProt 166–744 作者链 G； PDB构建体 1–579； UniProt 166–744 作者链 H； PDB构建体 1–579； UniProt 166–744

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	7oih
沉积日期 deposition_date	2021-05-11
结构标题 title	Glycosylation in the crystal structure of neutrophil myeloperoxidase
关键词 keywords	;Peroxidase, microbicidal, hypochlorous acid, glycosylation, paucimannose, hydrid N-glycan, polymorphonuclear leukocytes, dimer, ANTIMICROBIAL PROTEIN ;; ANTIMICROBIAL PROTEIN
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

7oih__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

7oih__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

7oih__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	34.49 Å
Rg（电子密度）	33.93 Å
总 Rg	34.51 Å
原子数	9660
残基数	1141
排除体积	171450 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`7oih__assembly_1__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`7oih__assembly_2__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
3	1	`7oih__assembly_3__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
4	1	`7oih__assembly_4__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (17)

实体 1 Entity 1 polymer

描述 description	Myeloperoxidase
分子量 formula_weight	66011.5 kDa
EC 编号 ec_number	1.11.2.2
来源方法 src_method	nat
拷贝数 entity_count	8

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H
原子数 atom_count	41050

TCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREA

实体 2 Entity 2 branched

描述 description	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	586.5 kDa
来源方法 src_method	man
拷贝数 entity_count	5

实体 3 Entity 3 branched

描述 description	;2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1260.2 kDa
来源方法 src_method	man
拷贝数 entity_count	3

实体 4 Entity 4 branched

描述 description	;alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1073.0 kDa
来源方法 src_method	man
拷贝数 entity_count	2

实体 5 Entity 5 branched

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	424.4 kDa
来源方法 src_method	man
拷贝数 entity_count	6

实体 6 Entity 6 branched

描述 description	;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1057.0 kDa
来源方法 src_method	man
拷贝数 entity_count	5

实体 7 Entity 7 branched

描述 description	;alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	748.7 kDa
来源方法 src_method	man
拷贝数 entity_count	1

实体 8 Entity 8 branched

描述 description	;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	748.7 kDa
来源方法 src_method	man
拷贝数 entity_count	2

实体 9 Entity 9 branched

描述 description	;alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ;
分子量 formula_weight	1073.0 kDa
来源方法 src_method	man
拷贝数 entity_count	1

实体 10 Entity 10 non-polymer

描述 description	CHLORIDE ION
分子量 formula_weight	35.5 kDa
来源方法 src_method	man
拷贝数 entity_count	36

实体 11 Entity 11 non-polymer

描述 description	CALCIUM ION
分子量 formula_weight	40.1 kDa
来源方法 src_method	man
拷贝数 entity_count	8

实体 12 Entity 12 non-polymer

描述 description	PROTOPORPHYRIN IX CONTAINING FE
分子量 formula_weight	616.5 kDa
来源方法 src_method	man
拷贝数 entity_count	8

实体 13 Entity 13 non-polymer

描述 description	THIOCYANATE ION
分子量 formula_weight	58.1 kDa
来源方法 src_method	man
拷贝数 entity_count	10

实体 14 Entity 14 non-polymer

描述 description	Paroxetine
分子量 formula_weight	329.4 kDa
来源方法 src_method	man
拷贝数 entity_count	4

实体 15 Entity 15 non-polymer

描述 description	PHOSPHATE ION
分子量 formula_weight	95.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	14

实体 16 Entity 16 non-polymer

描述 description	2-acetamido-2-deoxy-beta-D-glucopyranose
分子量 formula_weight	221.2 kDa
来源方法 src_method	man
拷贝数 entity_count	5

实体 17 Entity 17 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	2428

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晶胞边长 a length_a	155.910 Å
晶胞边长 b length_b	144.634 Å
晶胞边长 c length_c	236.454 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	91.53 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	32

空间群 space_group	C 1 2 1
空间群编号 int_tables_number	5
晶系 crystal_system	monoclinic

分辨率 resolution	2.603 Å
最低分辨率 resolution_low	38.994 Å
R 因子 r_factor	—
R_work r_work	0.1788
R_free r_free	0.2195

Glycosylation in the crystal structure of neutrophil myeloperoxidase

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Myeloperoxidase

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

7oih__assembly_1__model_1

7oih__assembly_1__model_1 | I(q)

7oih__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (17)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 branched

实体 3 Entity 3 branched

实体 4 Entity 4 branched

实体 5 Entity 5 branched

实体 6 Entity 6 branched

实体 7 Entity 7 branched

实体 8 Entity 8 branched

实体 9 Entity 9 branched

实体 10 Entity 10 non-polymer

实体 11 Entity 11 non-polymer

实体 12 Entity 12 non-polymer

实体 13 Entity 13 non-polymer

实体 14 Entity 14 non-polymer

实体 15 Entity 15 non-polymer

实体 16 Entity 16 non-polymer

实体 17 Entity 17 water

7. 引用文献 (2)

Glycosylation in the crystal structure of neutrophil myeloperoxidase

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Myeloperoxidase

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

7oih__assembly_1__model_1

7oih__assembly_1__model_1 | I(q)

7oih__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (17)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 branched

实体 3 Entity 3 branched

实体 4 Entity 4 branched

实体 5 Entity 5 branched

实体 6 Entity 6 branched

实体 7 Entity 7 branched

实体 8 Entity 8 branched

实体 9 Entity 9 branched

实体 10 Entity 10 non-polymer

实体 11 Entity 11 non-polymer

实体 12 Entity 12 non-polymer

实体 13 Entity 13 non-polymer

实体 14 Entity 14 non-polymer

实体 15 Entity 15 non-polymer

实体 16 Entity 16 non-polymer

实体 17 Entity 17 water

7. 引用文献 (2)