SAXSdb — 7s8c

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transient receptor potential cation channel subfamily V member 6

Homo sapiens

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count	Chain A； UniProt 41–707 Chain B； UniProt 41–707 Chain C； UniProt 41–707 Chain D； UniProt 41–707	Not recorded	ECL 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole × 4 Y01 CHOLESTEROL HEMISUCCINATE × 12 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 16 CA CALCIUM ION × 1 CL CHLORIDE ION × 1	ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE	Resolution 2.85 Å

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 7S8C	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
12AG Spermine-blocked open-state cryo-EM structure of human TRPV6 channel in cNW30 nanodiscs Deposited 2026-03-23	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 67–678（612 aa） Chain B 67–678（612 aa） Chain C 67–678（612 aa） Chain D 67–678（612 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions	Resolution 3.48 Å
6BO8 Cryo-EM structure of human TRPV6 in nanodiscs Deposited 2017-11-18	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 8；TRIS, NaCl, cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.60 Å
6BO9 Cryo-EM structure of human TRPV6 in amphipols Deposited 2017-11-18	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Not recorded	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 8；TRIS, NaCl, cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.00 Å
6BOA Cryo-EM structure of human TRPV6-R470E in amphipols Deposited 2017-11-18	Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Mutation：R470E Mutation：R470E Mutation：R470E Mutation：R470E	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 8；TRIS, NaCl, cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.20 Å
6D7S Cryo-EM structure of human TRPV6-Y467A in amphipols Deposited 2018-04-25	Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Mutation：Y467A Mutation：Y467A Mutation：Y467A Mutation：Y467A	No recorded non-water small molecule	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.34 Å
6D7T Cryo-EM structure of human TRPV6-Y467A in complex with 2-Aminoethoxydiphenyl borate (2-APB) Deposited 2018-04-25	Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Mutation：Y467A Mutation：Y467A Mutation：Y467A Mutation：Y467A	FZ4 2-aminoethyl diphenylborinate × 4 CA CALCIUM ION × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.44 Å
6E2F Cryo-EM structure of human TRPV6 in complex with Calmodulin Deposited 2018-07-11	Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Not recorded	CA CALCIUM ION × 6	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.90 Å
7K4A Cryo-EM structure of human TRPV6 in the open state Deposited 2020-09-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 52 CA CALCIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.26 Å
7K4B Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor cis-22a Deposited 2020-09-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	VUG 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(pyridin-3-yl)piperazine × 5 Y01 CHOLESTEROL HEMISUCCINATE × 8 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 48 CA CALCIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.10 Å
7K4C Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a Deposited 2020-09-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	81F 1-(5-bromopyridin-3-yl)-4-[cis-4-(3-methylphenyl)cyclohexyl]piperazine × 5 CA CALCIUM ION × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.78 Å
7K4D Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG Deposited 2020-09-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	VUM 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one × 5 CA CALCIUM ION × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.66 Å
7K4E Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 30 Deposited 2020-09-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	VUJ 5-({4-[(1R,4S)-3'-methyl[1,2,3,4-tetrahydro[1,1'-biphenyl]]-4-yl]piperazin-1-yl}methyl)pyridin-2(1H)-one × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 4.34 Å
7K4F Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 31 Deposited 2020-09-15	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	5GK 5-[(4-{cis-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one × 5 CA CALCIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.75 Å
7S88 Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent Deposited 2021-09-17	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 32 CA CALCIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.69 Å
7S89 Open apo-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs Deposited 2021-09-17	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 28 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 CA CALCIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.54 Å
7S8B Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red Deposited 2021-09-17	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–707（667 aa） Chain B 41–707（667 aa） Chain C 41–707（667 aa） Chain D 41–707（667 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 28 CA CALCIUM ION × 1 R2R ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.43 Å
8FOA Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein Deposited 2022-12-30	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 36 ZN ZINC ION × 2 CA CALCIUM ION × 1 GEN GENISTEIN × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.66 Å
8FOB Cryo-EM structure of human TRPV6 in the open state Deposited 2022-12-30	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–765（725 aa） Chain B 41–765（725 aa） Chain C 41–765（725 aa） Chain D 41–765（725 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 28 CA CALCIUM ION × 2	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.71 Å
8SP8 Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV) Deposited 2023-05-02	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 41–706（666 aa） Chain B 41–706（666 aa） Chain C 41–706（666 aa） Chain D 41–706（666 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 28 I8E Tetrahydrocannabivarin × 8 CA CALCIUM ION × 1 CL CHLORIDE ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.79 Å
9CUH Structure of human full-length ancestral TRPV6 channel in apo open state Deposited 2024-07-26	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 1–765（765 aa） Chain B 1–765（765 aa） Chain C 1–765（765 aa） Chain D 1–765（765 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 32 CA CALCIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.03 Å
9CUI Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state Deposited 2024-07-26	Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 1–765（765 aa） Chain B 1–765（765 aa） Chain C 1–765（765 aa） Chain D 1–765（765 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 8 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 43 CA CALCIUM ION × 7	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.42 Å
9CUJ Structure of human full-length derived TRPV6 channel in apo open state Deposited 2024-07-26	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 1–765（765 aa） Chain B 1–765（765 aa） Chain C 1–765（765 aa） Chain D 1–765（765 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 32 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 CA CALCIUM ION × 1	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.78 Å
9CUK Structure of human full-length derived TRPV6 channel in Calmodulin-bound state Deposited 2024-07-26	Different construct Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric	Chain A 1–765（765 aa） Chain B 1–765（765 aa） Chain C 1–765（765 aa） Chain D 1–765（765 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 8 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 43 CA CALCIUM ION × 7	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 3.26 Å
9NQ9 Magnesium ions-bound closed-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs Deposited 2025-03-12	Different construct Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric	Chain A 67–678（612 aa） Chain B 67–678（612 aa） Chain C 67–678（612 aa） Chain D 67–678（612 aa）	Not recorded	Y01 CHOLESTEROL HEMISUCCINATE × 12 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 16 MG MAGNESIUM ION × 5	ELECTRON MICROSCOPY cryo-EM buffer pH 8 cryo-EM vitrification conditions Cryogen ETHANE	Resolution 2.97 Å

24 other PDB entries and 24 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	TRPV6_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–667； UniProt 41–707 Author chain B； PDBConstruct 1–667； UniProt 41–707 Author chain C； PDBConstruct 1–667； UniProt 41–707 Author chain D； PDBConstruct 1–667； UniProt 41–707

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7s8c
Deposition date deposition_date	2021-09-17
Structure title title	Cryo-EM structure of human TRPV6 in complex with inhibitor econazole
Keywords keywords	;Transient Receptor Potential V Family Member 6, TRP, channel, econazole, inhibitor, antagonist, cNW11, nanodiscs, TRPV6, MEMBRANE PROTEIN ;; MEMBRANE PROTEIN
Experimental Method method	ELECTRON MICROSCOPY

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	47.29 Å
Radius of gyration Rg (electron density) rg_electron	46.04 Å
Forward intensity I(0) i0	1067020000.00
Molecular weight molecular_weight	292820.0 kDa
Excluded volume excluded_volume	375190 Å³
Envelope volume envelope_volume	502810 Å³
Hydration-shell volume shell_volume	87587 Å³
Envelope diameter envelope_diameter	145.5 Å
Shell Rg shell_rg	53.83 Å
Envelope Rg envelope_rg	44.96 Å
Shape Rg shape_rg	46.04 Å
Total Rg total_rg	46.33 Å
Total atoms total_atoms	20562
Residues n_residues	2448
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	140.7 Å
Rg (real space) rg_real	46.88 Å
Rg uncertainty (real space) rg_real_error	0.98 Å
I(0) (real space) i0_real	1.0670e+09
I(0) uncertainty (real space) i0_real_error	1.8390e+07
Rg (reciprocal space) rg_reciprocal	47.28 Å
I(0) (reciprocal space) i0_reciprocal	1068000000.0000
Solution quality estimate total_estimate	0.8864
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	1
Primary peak position r_peak_primary	64.0 Å
Skewness Skewness skewness	-0.034
Kurtosis Kurtosis kurtosis	-0.579
Angular range angular_range	— – 0.1650 Å⁻¹
Current regularization parameter α current_alpha	0.0000
Highest regularization parameter α highest_alpha	54060000.0000
Real-space data points n_real_points	34
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.940; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.959; Smooth: 0.739

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (6)

Entity 1 Entity 1 polymer

Description description	Transient receptor potential cation channel subfamily V member 6
Molecular weight formula_weight	78421.3 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D
Atom count atom_count	20562

MGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLVPRGSAAAWSHPQFEK

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	Human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Homo sapiens

Entity 2 Entity 2 non-polymer

Description description	1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Molecular weight formula_weight	381.7 kDa
Source method src_method	syn
Copy count entity_count	4

Entity 3 Entity 3 non-polymer

Description description	CHOLESTEROL HEMISUCCINATE
Molecular weight formula_weight	486.7 kDa
Source method src_method	syn
Copy count entity_count	12

Entity 4 Entity 4 non-polymer

Description description	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
Molecular weight formula_weight	760.1 kDa
Source method src_method	syn
Copy count entity_count	16

Entity 5 Entity 5 non-polymer

Description description	CALCIUM ION
Molecular weight formula_weight	40.1 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 6 Entity 6 non-polymer

Description description	CHLORIDE ION
Molecular weight formula_weight	35.5 kDa
Source method src_method	syn
Copy count entity_count	1

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7. Fold Classification (SCOP + CATH) 4 domains

CATH v4.4 (4 domains)

Domain ID domain_id	7s8cA01
Class class	1 — Mainly Alpha
Architecture architecture	25 — Alpha Horseshoe
Topology topology	40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily	20 — Ankyrin repeat-containing domain

Domain ID domain_id	7s8cB01
Class class	1 — Mainly Alpha
Architecture architecture	25 — Alpha Horseshoe
Topology topology	40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily	20 — Ankyrin repeat-containing domain

Domain ID domain_id	7s8cC01
Class class	1 — Mainly Alpha
Architecture architecture	25 — Alpha Horseshoe
Topology topology	40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily	20 — Ankyrin repeat-containing domain

Domain ID domain_id	7s8cD01
Class class	1 — Mainly Alpha
Architecture architecture	25 — Alpha Horseshoe
Topology topology	40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily	20 — Ankyrin repeat-containing domain

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8. Citations (1)

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.85 Å
Resolution测定方法 resolution_method	—
颗粒数 num_particles	41635

fit	/app/data/saxs_computation/s8/7s8c/7s8c.fit
pddf	/app/data/pr_computation/s8/7s8c/7s8c.pr.out
profile	/app/data/saxs_computation/s8/7s8c/7s8c.dat

Cryo-EM structure of human TRPV6 in complex with inhibitor econazole